Following the people and events that make up the research community at Duke

Students exploring the Innovation Co-Lab

Category: Students

A few small steps for mankind

By Becca Bayham

Eureka Symposium“There are the thermometers who passively record social injustices, and then there are the thermostats that actively do something about it,” Dr. Sunny Kishore said during the Eureka Symposium last Saturday, a dPS-sponsored event that brought together 120 students and a number of Duke alums for some deep thinking about social change.

The main lecturers were followed by break-out sessions, which ranged in topic from global health to human rights. The four-hour symposium packed a philosophical punch, outlining a few actions that could save millions or even billions of lives in the developing world. It’s probably the most inspired I’ve felt on a Saturday afternoon.

Representatives from the Enough Project made the case for using conflict-free minerals on campus (similar to the idea behind conflict-free diamonds). Tin, tantalum, coltan and gold — used in cell phones and other electronics — currently fuel war in eastern Congo, where various armed groups mine them for profit; more than five million people are thought to have died from the conflict so far. (Following a rather pointed editorial in the Chronicle by two Symposium organizers, Duke Procurement stated on its website that it would “[give] preference to vendors who have made a commitment to conflict-free supply chains when quality and cost performance are equal or superior.”)

Drs. Anthony So, Robert Johnston and Kishore discussed strategies that could provide people in developing nations with access to life-saving treatments and vaccines — at a price they can afford. Triple therapy for AIDS used to cost $10-15,000, “too high a price for hope,” So said. But thanks to ‘bootstrap philanthropy’ — free licenses and free production, supported by grant money — that same treatment costs less than $100 now.

Royalty fees and license exclusivity have usually put vaccines out of reach for the developing world, unless the drug is off-patent. Johnston (of Global Vaccines, Inc.) proposed one solution: commercial sub-licenses, which allow low-cost manufacturers to produce affordable vaccines without violating companies’ intellectual property rights.

“You have the ability to have a drug at first-world prices in developed countries and can now provide lower-cost medicines in developing countries,” Kishore said.

Research universities could play a pivotal role by allowing “humanitarian licenses” of their technologies, according to Kishore. Several universities — Duke among them — have signed a statement supporting dissemination of medical technologies, but not much progress has been made.

“Are we engaged in rhetoric or are we engaged in actually doing something?” Kishore said. “These are our labs, our drugs, and this is our responsibility.”

Changing American science and engineering education

TIP India 2009

Students in India work on a forensics experiment. Image courtesy of Duke TIP.

By Viviane Callier, graduate student in Duke Biology

It’s no secret that primary and secondary education in the U.S. falls behind when compared to many other developed countries.

David Kahler, a recent Ph.D. graduate from Duke’s Environmental Engineering program, has been involved in several education and outreach programs that aim to address this problem.

During his graduate career at Duke, Kahler participated in a National Science Foundation (NSF) Graduate Fellows program, which provides support for graduate students in science, technology, engineering, and mathematics, also known as STEM. The program is called NSF GK-12.

In exchange for funding for their graduate studies, Kahler and other fellows contribute to the science curriculum in local primary and secondary schools from kindergarten through grade 12. Kahler taught science at Rogers-Herr Middle School in Durham.

He also taught for two summers in India, and in Texas, as part of Duke TIP, the Talent Identification Program, which identifies academically gifted students and provides them with intellectually stimulating opportunities.

Through these teaching experiences in different locations and cultures, Kahler observed several factors that affect the quality of education in American schools. One important factor is the training of teachers. Unfortunately, teachers are sometimes expected to teach science without having received an adequate background in the subject.

STEM fellows helped to address this problem by contributing their expertise and by helping to increase the scientific literacy of students and their teachers.

Another issue is that parents in the U.S. are often not involved in their children’s education and do not support the mission of both schools and teachers. As a result, children are not engaged in or committed to their own education. In contrast, Kahler found that in India, children are taught by their parents to value and take responsibility for learning.

Because of this difference in attitude toward education, too many American high school graduates are inadequately prepared for college.

Kahler says that NSF GK-12 has a strong, positive impact to change this because it simultaneously improves the educational experience of students in primary and secondary school and trains graduate students to communicate and teach effectively.

Unfortunately, the NSF GK-12 program is no longer in the NSF budget for 2012.

Science Under the Stars

Building on earlier successes with K-12 classroom outreach and a huge appearance at the 2010 USA Science and Engineering Festival, Duke University students and faculty are inviting Triangle-area families to join them for an evening of interactive science demonstrations called SCIENCE UNDER THE STARS.

USA Science and Engineering Fest

Duke students wowed kids and grownups alike at last year's national science festival in Washington DC.

The October 19 festival will include hands-on, all-ages activities from Chemistry, Physics, Biology, Engineering, Genomics, Environmental Science,  Microbiology, Immunology, and Molecular Genetics.

SCIENCE UNDER THE STARS will be from 6 p.m. to 8 p.m. on Wednesday, Oct. 19, on the front lawn of the French Family Science Center on Duke’s West Campus.

At 7:30, the chemists will stage a spectacular grand finale — not quite fireworks, but close!

Free parking is available in the Chemistry parking lot at Research Drive and Towerview, and overflow parking will be available in the Bryan Center structure on Science Drive as well.

RAIN DATE – Thursday, Oct. 20.

For more information contact Kenneth Lyle, PhD at kenneth.lyle@duke.edu

 

Newbie has Arrived!

Contest for the cutest face with my friends.

Drumroll Please.
And it is . . . Jeannie Chung.

Hello Everyone! I am a new blogger for the Duke Research Blog. My name is Jeannie Chung and I am a freshmen currently enrolled in the Pratt School of Engineering as a prospective Mechanical Engineering and Electrical Engineering double major. But as I said, it is “prospective” since I have too many interests to keep me confined in a narrow-minded decision.

One of my biggest excitements about college is that I am invited to listen and share the ingenious ideas of others! Duke University is one of the biggest research schools out there and thus more ideas, ingenuity, and mind-blowing opportunities!

I like taking photos, going to art exhibitions and movies. I’m an avid lover of coffee and tea (no sugar and milk ruining the taste, please!), a music lover (playing and listening), dancer (I try), and an experimental cook.

I am not so fond of sweets, but I do sometimes seek after them. If I have to choose an ice cream I would always go with lemon sherbet gelato, or the classic mint. I love having conversations with people and am always excited to make new friendships.

My family is my number one treasure, and that includes my golden retriever, Dian, and my tuxedo cat, Secret. There are stories that go with those names, but perhaps we can talk about them later. My current goal is to be able to speak all three oriental languages when I graduate and to build a transformer in the future, preferably one from a Yellow Camerro.

Hey there, fellow Dukies!

My name is Pranali Dalvi, and this is my first post as one of the voices for Duke’s Research Blog!

I am a sophomore from Lakeland, Florida in Trinity (just like my twin sister Prachiti) looking at studying some combination of biology, chemistry, and global health – at least, for now.

When I’m not blogging, you can probably find me eating Loopwiches (a chocolate-chip-cookie-and-ice-cream sandwich) at the Loop, going to cardio dance, reading the New York Times, shopping online at Banana Republic, or doing cancer biology research. I am a huge Cameron Crazie, and I love cheering on the Blue Devils in Cameron Indoor! In fact, lately I’ve been brainstorming ideas for poster slogans for Duke basketball games, so I can get my claim to fame on ESPN.

Although I’ve tried out cheerleading, ballet, gymnastics, ice skating, horseback riding, Indian classical dance, swimming, tennis, and golf, I like playing the piano most and have been playing for 12 years now.

I’ve been fascinated by the power of language ever since the eighth grade when I went to the National Spelling Bee. Upon entering high school, I outgrew spelling bees, and science fairs became my new competitive outlet.

Science fairs introduced me to the world of discovery-driven research. This is a world in which you never have to lose your childlike curiosity and you can ask questions until you find answers. What brings researchers together, however, is not the experimentation that happens in lab but rather the lab meetings, conferences and conversations that follow.

Fortunately, we are on prime real estate at the heart of the Research Triangle! We have access to these meetings, conferences and conversations and can glean from them the wisdom and knowledge of these renowned researchers. Through this blog, I look forward to sharing my experiences with you!

Hello!

A very warm welcome to you from one of the Research Blog’s newest bloggers!

My name is Prachiti Dalvi, and I am a sophomore in Trinity from Lakeland, Florida. For now, I am studying biology and chemistry; however, I have yet to officially declare my major.

I am absolutely STOKED to be a blogger for Duke’s Research Blog! I started blogging this past summer when I worked in a cell biology lab in the Medical Center. I fell in love with the idea of archiving and reflecting on my experiences. (And, I also thought it was really cool to check my site stats everyday to see how many hits my blog was getting!)

In my free time, I love playing the piano, watching Duke basketball, hanging out with friends on the plaza, reading the New York Times, dancing, travelling with my family and spending time with my twin sister, who happens to be my roommate and is (surprise, surprise…) a blogger for this site too!

Luckily, I stumbled on research when I was a freshman in high school and have been going strong since. I am wholly fascinated by the world of research because it allows scientists to flit along the fine boundary between the known and the unknown.

The cohesive efforts of many individuals, the diligence exhibited when experiments fail and an undying curiosity for the unfamiliar are embodied in a discovery – a discovery that has the potential to explain the simplest of phenomena or to change thousands of lives. I am a true believer in the ability of innovative thinking to find solutions to even the most intricate problems.

As a student at a world-renowned research institution, I look forward to sharing Duke’s research sphere with you through my eyes and hope that you enjoy reading my posts as much as I enjoy writing them!

Exploring the "last frontier" of our genome

human centromeres

In this image of a human cell, the centromeres are the pink spots and the blue "sticks" are chromosomes. Image courtesy of Karen Hayden, Duke.

Guest post by Viviane Callier, Duke biology

The human genome first appeared in print in 2001. But scientists aren’t done yet. There’s part of our DNA that geneticists have yet to assemble a sequence for: the centromeres.

Centromeres are necessary for chromosomes to segregate during cell division so that each new cell receives a complete copy of the genome. If chromosome segregation does not occur correctly, the resulting cells could die or become cancerous.

The sequence of centromeres remains one of the mysterious regions in the human genome because these areas are made of highly repetitive DNA sequences called satellite DNAs, said Karen Hayden, a recent graduate of Hunt Willard’s lab in Duke’s IGSP.

Centromere sequences are currently represented as gaps or spaceholders in the genome. Hayden, however, has developed a new strategy to study these elusive arrangements of DNA.

To study genomic material, scientists first break it into small pieces and sequence them. Then, much like a puzzle, they reassemble the pieces into the full sequence.

But when highly repetitive DNA, such as is found in centromeres, is broken into pieces, the parts of the puzzle look strikingly similar. As a result, scientists have trouble knowing if they have truly reassembled the pieces into the original sequence.

Using computational methods and studying the centromere sequences in the lab, however, Hayden was able to solve the puzzle and determine sequence arrangement in human centromeres. She also created a database to analyze the variations in among centromere sequences in the human genome.

Hayden said she hopes that the experiments she designed, along with the database of sequences, will provide the tools to study whether certain centromere sequences are more highly associated with diseases, such as cancer and birth defects.

This fall she will go to the Segal Lab at the Weizmann Institute in Israel to model the physical properties of centromeric sequences and study if centromeric sequences play a role in the centromere function. She then plans to continue her work in David Haussler’s lab at UC Santa Cruz.

Envision Yourself A Winner

The second Abhijit Mahato visualization contest, “Envisioning the Invisible” is now underway, and you don’t have to be a member of the Duke community to participate.

Post-doctoral fellow Anna Loksztejn of the Center for Biologically Inspired Materials created this image of aggregated insulin proteins using atomic force microscopy.

Last year’s first contest was a stunning success, both for the images it produced and what the symbolism it represented — making something beautiful out of something very ugly. Mahato was a second-year graduate student in the Pratt School of Engineering who was murdered in his apartment near campus in 2008, pretty much at random. His friends and colleagues wanted to do something long-lasting and worthy of Abhijit’s memory.

 

You can learn more about the contest at this site. There are two categories: making something ordinary beautiful, and making scientific data into a picture.

The gala awards ceremony and slideshow, with keynote speaker Nickolay Hristov, is set for 5 p.m. Wednesday Sept. 28 in Schiciano Auditorium.

Here are the rules. Hurry, the contest ends at Midnight, Sept. 7!

Duke Research Blog 3.0

Welcome to Duke Research Blog, Version 3, on WordPress.

2011 Blog team

Clockwise from upper left: Ashley, Becca, Vansh and Karl

The packaging has changed, but the blog is the same. We’ll be covering the people and events that capture the excitement and energy of Duke’s research environment; interesting findings, fascinating seminars, super-luminary guest speakers, amazing students.

Seniors Becca Bayham and Vansh Muttreja will be with us again this year, along with Science Writer Ashley Yeager and yours truly, Karl Bates, director of research communications. Biology graduate student Viviane Callier, who contributed a couple of interesting posts over the summer, may add some to the mix as well. And we’re working on hiring one or two NEW bloggers this fall to be ready for the departure of our star seniors in the spring. …I’m already getting sad about that!

Back Issues:

We began this blog on the Google blogger service in 2007. You can relive that amazing experience here.

In May 2010, it moved to a blog on the Duke Research site.

Please stay with us, check in often, talk to us, and share with your friends!

It's coming!

While the work-study bloggers are gone for the summer (but still bloggin‘!), we’ll try to complete the setup and get this here blog on the Interwebs!

Prefab house by Vesta from Wikimedia Commons

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