Following the people and events that make up the research community at Duke

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‘Design Climate’ Students Pitch Solutions at Energy Week 2024

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Amid the constant drumbeat of campus events, much of the conversation turned toward the challenges we face in energy policy, security and transitions during Duke’s annual Energy Week, held Nov. 11-15.

On the second day, the Innovation Showcase featured not only startups making their pitches for clean energy and sustainable tech products, but students doing so as well. 

Currently in its second year, Duke Design Climate is a new initiative between the Pratt School of Engineering and the Nicholas School of the Environment. It functions as a two-course sequence, in which students form groups to prototype and promote climate solutions after conducting market research.

As I made my rounds to the teams, I met a mix of graduate students and undergraduates with academic backgrounds ranging from engineering to economics to environmental science. The ideas they have aren’t purely theoretical: all are looking for sponsors or partners to help implement their solutions into real-world use. Here were some of the highlights:    

Team ReefCycle is building from plants: Our first stop is named after the company whose product they intend to scale up. Initially, Mary Lempres founded ReefCycle to develop sustainable material for artificial reefs. Regular industrial production for cement requires intensive heating– burning of fossil fuels–releasing tons of carbon dioxide. ReefCycle sought to reduce this climate impact with a different method: their cement is plant-based and enzymatic, meaning its essentially grown using enzymes from beans. Testing in the New York Harbor yielded some promise: the cement appeared to resist corrosion, while becoming home for some oysters. The Design Climate team is now trying to bring it to more widespread use on land, while targeting up to a 90% reduction in carbon emissions across all scopes.

Team Enfield is uplifting a local community: Design Climate, evidently, is by no means limited to science. Instead, these team members intend to address an environmental justice issue close to home: energy inequality. Around 30-35% of Enfield residents live below the poverty line, and yet suffer from some of the highest energy bills in the larger area. Located a ninety minute drive east of Durham, this rural town is one of the poorest in North Carolina. Historic redlining and unfavorable urban planning are responsible for its lack of development, but now this team aims to bring back commerce to the area through microfinance. Once enough funding is gathered from investors and grants, the team hopes to provide microloans and financial literacy to spur and empower businesses. 

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Team Methamatic promotes a pragmatic e-methane solution: This team is harnessing the power of sunlight to drive fuel production. Synthetic methane, commonly referred to as e-methane, is produced by reacting green hydrogen and carbon dioxide. “Currently, the power-to-gas process can be carbon neutral,” said team member Eesha Yaqub, a senior. “Sourcing the recycled carbon dioxide from a carbon capture facility essentially cancels out the emissions from burning methane.” However, this power-to-gas (P2G) process is an intensive one requiring high heat, energy, and pressure–hoops that might not have to be jumped through if an alternative process could break through the market. Professor Jie Liu and the Department of Chemistry have been working on developing a reactor that would conduct this same reaction without those obstacles. “[Utilizing] the energy from ultraviolet light, which is absorbed by a catalyst …makes the process less energy intensive,” Yaqub said.

Right now, the team has a small prototype, but one used for commercial generation would appear much larger and cost between $15,000 to $20,000. Their intended customers? Oil and gas companies under pressure to shift away from fossil fuels. If successfully scaled up, they predict this process would produce e-methane at a price of $5 per kilogram. 

Analyzing living shorelines through Team Coastal Connect: If “Coastal Connect” sounds more like an app than a project name, that’s because it is one. This group is designing what one member dubbed a “fitbit for shorelines”: a monitoring system that brings data from ocean buoys to the phones of local landowners. While measurements in salinity and water level aren’t always telling for the average person, the app would contextualize these into more useful phrases. Is it currently safe to swim? It’ll let you know.

Moreover, it would also allow for the long-term monitoring of living shorelines. While we know this nature-based solution offers resilience to natural disasters and presents erosion, short-term fixes like seawalls are often built instead to continue allowing development up to the edge of beaches. The team hopes that ideally, providing concrete data on living shorelines would allow us to demonstrate their benefits and promote their implementation. 

By Crystal Han, Class of 2028

Invented at Duke, Inspired at Duke

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“Our technology is tailored towards scanning animals. In fact, we can run scans on entire organisms!” 

Image from the Photoacoustic Imaging Lab that made it onto the front page of Science: glassfrog transparency!

Excitedly, Soon-Woo Cho, a postdoctoral associate in the Photoacoustic Imaging Lab, referred me to the standing poster at the Nov. 20 Invented at Duke showcase. While I stood puzzled looking intensely at the articulate images, I suddenly realized that the jumble of blue and red outlined the shape of a frog! 

As one could imagine, this technology, the masterpiece invention of biomedical engineering professor Junjie Yao and his team, is too advanced for a first-semester undergraduate to understand.

Soon-Woo  Cho
Soon-Woo Cho, postdoctoral fellow with the Photoacoustic Imaging Lab.

Nonetheless, Cho patiently explained its basic mechanisms to me in simpler terms. One of the technology’s key attributes was its speed; while traditional imaging counterparts were known for their long processing times, Yao’s team was able to reduce that time to mere seconds.

Another accomplishment is the product’s versatility and widespread application. Not only can the system distinguish between arteries and veins, coloring them as red and blue respectively, it can also play an important role in diagnosing cancer cells, as these malignant cells are known for inducing abnormal growth of surrounding blood vessels. 

After hearing this inspirational work, I traveled a few steps to another booth. While both research projects take place within the biomedical engineering department, their focus could not be more different. Ruth Verrinder, a current PhD student working in Jonathan Viventi’s lab, explained to me how the flexible electrode strips on display are part of an effort to address a significant medical need.

Ruth Verrinder
Ruth Verrinder, PhD student and member of the Viventi Lab.

Today, many surgeries to treat epilepsy are disappointingly unsuccessful. Even after a lengthy medical process including diagnosis and highly intensive treatment and procedures, such failures are simply too much to bear for many patients and families. The Viventi Lab believes that through improving the quality and quantity of data collected by medical electrodes, more surgical successes would naturally follow.

Their current product is already in use at Duke, and the team has ambitious plans for further developing the product.  The top priority is to build implantable electrodes so brain signals could be tracked for weeks to months before prospective surgeries, better informing surgeons and medical professionals on the specific patient’s conditions.  

While the booths hosting major inventions attracted the most fanfare, many other organizations were also present. One can hardly avoid the history exhibition: the bending, wave-like wall of “A Century of Innovation at Duke” greeted every visitor as they walked in the Penn Pavilion doors. On the other side of the wall, a history table curated by the Rubenstein Library displayed remarkable patents from Blue Devils across time, not to mention the popular button-making station that touted designs like “I love patents!”  

Although the acclaimed Dr. Robert Califf, director of the Food and Drug Administration, did not make it to the event, the occasion was nonetheless an overwhelming success. As a biomedical engineering student, I got to witness some of the most advanced research occurring in my field of study and meet prominent faculty. In the crowd of attendees, many students, regardless of undergraduate or graduate, studying humanities or the sciences, huddled around posters while inquisitively listening to inventors. Even academics from other institutions came to attend the sixth annual Invented at Duke: while I was learning more about the Viventi Lab’s research, a scholar from the University of Georgia joined the huddle and posed questions. 

Even as all attendees, including myself, were astounded by the ingenious discoveries presented, I think there is a deeper takeaway than simply being “wowed” by incredibly advanced brain electrodes or imaging systems.

As stressed by the Office of Translation and Commercialization, Office of Innovation and Entrepreneurship, and Nucleate, a student-led organization focused on biotechnology innovation, groundbreaking development is feasible and not a feat to be done alone. For those with bold ideas, there are innumerable resources on campus to help bring those visions into reality.

For those interested in innovation but do not have the “sparks,” there are countless ways to get involved with existing projects and find one that suits your passions. Above all, those whose interest lies beyond biomedical sciences should not be discouraged: if there are current initiatives aimed at improving satellite images, there are surely many other non-biomedical endeavors for you to explore! 

Let us not only celebrate what’s invented, but also the thriving spirit of invention here at Duke. Onwards! 

Stone Yan, class of 2028

From Immune Responses to Private Equity, New Series Offers “Research On Tap”

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On every third Thursday of the month, Devil’s Krafthouse is host to Research on Tap: a series that gives Duke researchers, from undergraduates to postdoctoral fellows, the opportunity to present their work in a casual setting. It may seem odd for the procedures of academia to make their way into a space for socialization and entertainment, but this situation allows individuals to practice speaking publicly to a general audience under a short time limit–good conditions for developing their “research elevator pitch.” These were the pitches on October 17:

As it’s name suggests, Cv is a bacterium violet in color. Photo courtesy of Dr. Edward Miao and Dr. Carissa Harvest.

Jacqueline Trujillo, a Ph.D. student in the Department of Molecular Genetics and Microbiology, who is part of Dr. Edward Miao’s lab, presented her research on immune cell response to the bacterium Chromobacterium violaceum (Cv). Being an environmental pathogen, Cv usually resides in the soil of tropical and subtropical areas. While disease in humans is rare, the mortality rate is high in immunocompromised individuals.   

“The Miao Lab was initially studying pyroptosis, a form of cell death that occurs during infection, when they discovered Cv-induced granulomas,” Trujillo said. Granulomas are specialized structures that are formed to contain and eradicate pathogens, but they can range in the arrangement and type of cells they consist of; one induced by tuberculosis infection, for example, would include adaptive immune cells like T and B cells. However, when the pathogen inducing them is Cv, only innate immune cells are present: neutrophils in the inner cluster and inflammatory macrophages in the outer cluster. When Cv is detected, neutrophils are the first to flock to the site of infection in a “toxic swarm.”  The neutrophils themselves are typically able to effectively kill microbes even before granuloma formation. “These are one of the most toxic defending cell types in the immune system,” Trujillo said.  

Despite this, the lab observed something unusual: these neutrophils failed to kill off the Cv bacteria, which continued to replicate despite the swarm. The lab ultimately saw Cv eliminated by the innate granulomas within about 21 days, but the ability to survive the neutrophils is what Trujillo now aims to understand. Such a feat from an environmental bacterium comes as a surprise, being “something more characteristic of the causative agent [Yersinia] of the bubonic plague,” Trujillo said. A comparison between the proteins CopH and YopH, virulence effectors in Cv and Yersinia respectively, reveals lots of similarities between the two. Trujillo hypothesizes that CopH is part of the secret to how Cv disarms the immune system’s defenses.

The role of virulence effectors is generally “aid[ing] in survival, invasion, and suppressing immune responses.” Through needle-like structures, bacteria inject these proteins into a host cell. A cell responds to this in two main ways. It dies–initiating pyroptosis to prevent the pathogen from replicating inside the cell.  Second, it signals for help by making chemical messengers called inflammatory cytokines.  Investigating the first response is what led the Miao Lab to Cv-induced granulomas.

Now, the lab is interested in understanding the regulatory signals that form the granuloma–and the role that inflammatory cytokines might play, if any. In addition to testing her hypothesis on CopH, Trujillo intends to determine if neutrophils respond to Cv’s initial survival by producing the cytokine IL-18, thus recruiting immune cells to the infection site. This would help the Miao Lab confirm their idea that the neutrophils’ failure to clear Cv is what prompts the process of granuloma formation.  

With much still unknown in the area of granuloma biology, Cv provides an “excellent model for studying immune cell biology and characterizing bacterial virulence effectors,” Trujillo said.  

Though it happens that many Research On Tap speakers are in the sciences, the program isn’t discipline-specific. Our second researcher of the evening, Sungil Kim, studies a far different field from Jacqueline.  

Photo courtesy of Hong Chung.

As a Ph.D. student in Finance at the Fuqua School of Business, Kim is looking at the effects of a growing trend in recent years: private equity (PE) firms acquiring healthcare companies. His focus is on what’s known as the “buy-and-build”, as this business strategy is often used by such firms entering the healthcare sector. The scenario typically looks like this: a private equity firm first acquires a large existing company, called the platform company or “first deal.” They’ll then acquire several smaller companies, or “add-on deals,” in order to expand the platform company’s operations.  

Since private equity firms buy businesses with the eventual goal of selling them at a profit, their primary focus is increasing efficiency to reduce costs. On one hand, these buyouts might be seen as beneficial for languishing businesses in need of operation enhancements. But within the healthcare sector, many worry the resultant cost-cutting will lead to declining standards of care for patients.   

Kim set out to investigate if operational improvements are sustainable across multiple acquisitions within the buy-and-build framework. The simple answer? No. 

Kim confirmed that, on average, private equity firms improve the operational performance of hospitals without hurting quality, “a finding that agrees with some of the previous literature.” Yet, one only needs to take a closer look into the sequence of deals to uncover a different, more complicated story.  

To arrive at his answer, Kim considered three main factors–operational efficiency, profitability and quality–in both the platform company and add-on companies. Platforms, or first acquisitions, did see success in performance, but this came with what appears to be a trade-off, as the first two factors increased while quality went down. As in, quality of healthcare. From one of Kim’s graphs, it was apparent that occurrences of four of the six health outcomes measured, including mortality and remission of heart failure, increased in such first deal situations.  

Meanwhile, results for the add-ons changed little before and after the buyout, meaning that the initial success from the platform didn’t carry over to later acquisitions, even as reduced costs did. A potential reason for this inability to replicate success, Kim explained, is that these cost savings may come from reducing the number of patients and services, instead of truly improving the efficiency of operations. 

In contrast to academic journals that display research that’s been in the works for years, Research on Tap brings us closer to working papers in their ongoing, exploratory stages. While it’s difficult to draw wider conclusions from Kim’s findings just yet, and important to remember the specific first deal context of this study, research like his helps us further understand the issues facing improvement of our healthcare system and where private equity plays a role.

If you’re interested in learning something new and free Krafthouse bites, swing by and attend a session–the next one occurs on November 21, 2024 at 5 p.m. The program welcomes prospective speakers to place themselves on the waitlist for a spot.

By Crystal Han, Class of 2028

Duke experts discuss the potential of AI to help prevent, detect and treat disease

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Sure, A.I. chatbots can write emails, summarize an article, or come up with a grocery list. But ChatGPT-style artificial intelligence and other machine learning techniques have been making their way into another realm: healthcare.

Imagine using AI to detect early changes in our health before we get sick, or understand what happens in our brains when we feel anxious or depressed — even design new ways to fight hard-to-treat diseases.

These were just a few of the research themes discussed at the Duke Summit on AI for Health Innovation, held October 9 – 11.

Duke assistant professor Pranam Chatterjee is the co-founder of Gameto, Inc. and UbiquiTx, Inc. Credit: Brian Strickland

For assistant professor of biomedical engineering Pranam Chatterjee, the real opportunity for the large language models behind tools like ChatGPT lies not in the language of words, but in the language of biology.

Just like ChatGPT predicts the order of words in a sentence, the language models his lab works on can generate strings of molecules that make up proteins.

His team has trained language models to design new proteins that could one day fight diseases such as Huntington’s or cancer, even grow human eggs from stem cells to help people struggling with infertility.

“We don’t just make any proteins,” Chatterjee said. “We make proteins that can edit any DNA sequence, or proteins that can modify other disease-causing proteins, as well as proteins that can make new cells and tissues from scratch.”

Duke assistant professor Monica Agrawal is the co-founder of Layer Health. Credit: Brian Strickland

New faculty member Monica Agrawal said algorithms that leverage the power of large language models could help with another healthcare challenge: mining the ever-expanding trove of data in a patient’s medical chart.

To choose the best medication for a certain patient, for example, a doctor might first need to know things like: How has their disease progressed over time? What interventions have already been tried? What symptoms and side effects did they have? Do they have other conditions that need to be considered?

“The challenge is, most of these variables are not found cleanly in the electronic health record,” said Agrawal, who joined the departments of computer science and biostatistics and bioinformatics this fall.

Instead, most of the data that could answer these questions is trapped in doctors’ notes. The observations doctors type into a patient’s electronic medical record during a visit, they’re often chock-full of jargon and abbreviations.

The shorthand saves time during patient visits, but it can also lead to confusion among patients and other providers. What’s more, reviewing these records to understand a patient’s healthcare history is time-intensive and costly.

Agrawal is building algorithms that could make these records easier to maintain and analyze, with help from AI.

“Language is really embedded across medicine, from notes to literature to patient communications to trials,” Agrawal said. “And it affects many stakeholders, from clinicians to researchers to patients. The goal of my new lab is to make clinical language work for everyone.”

Duke assistant professor Jessilyn Dunn leads Duke’s BIG IDEAs Lab. Credit: Brian Strickland

Jessilyn Dunn, an assistant professor of biomedical engineering and biostatistics and bioinformatics at Duke, is looking at whether data from smartwatches and other wearable devices could help detect early signs of illness or infection before people start to have symptoms and realize they’re sick.

Using AI and machine learning to analyze data from these devices, she and her team at Duke’s Big Ideas Lab say their research could help people who are at risk of developing diabetes take action to reverse it, or even detect when someone is likely to have RSV, COVID-19 or the flu before they have a chance to spread the infection.

“The benefit of wearables is that we can gather information about a person’s health over time, continuously and at a very low cost,” Dunn said. “Ultimately, the goal is to provide patient empowerment, precision therapies, just-in-time intervention and improve access to care.”

Duke associate professor David Carlson. Credit: Brian Strickland

David Carlson, an associate professor of civil and environmental engineering and biostatistics and bioinformatics, is developing AI techniques that can make sense of brain wave data to better understand different emotions and behaviors.

Using machine learning to analyze the electrical activity of different brain regions in mice, he and his colleagues have been able to track how aggressive a mouse is feeling, and even block the aggression signals to make them more friendly to other mice.

“This might sound like science fiction,” Carlson said. But Carlson said the work will help researchers better understand what happens in the brains of people who struggle with social situations, such as those with autism or social anxiety disorder, and could even lead to new ways to manage and treat psychiatric disorders such as anxiety and depression.

Credit: Brian Strickland.
Robin Smith
By Robin Smith

Rosetta Reitz: The Life Behind the Music

A 1983 New Yorker article by Whitney Balliet argued that “Women don’t have the grace and poise to play jazz.” While this comment wasn’t uncommon for the time, it certainly wasn’t universally accepted. In fact, this comment is what feminist writer and producer, Rosetta Reitz, sought to disprove through her decades-long efforts to promote underrepresented records. 

This past Tuesday Feb. 6, the “Rosetta Reitz’s Musical Archive of Care” Bass Connections team hosted a discussion pertaining to the origins, findings, and thought process of this archive. Leading this discussion were researchers Anthony Kelley, Duke Professor, and Tift Merritt, Grammy-nominated musician.  In this, the pair explored the key theme of artistic empathy utilized through the archival process. Archival artistic empathy describes the act of not making yourself the center of your findings but allowing them to enlarge your compassion. This theme was pertinent not only for Merritt’s research journey but also for that of Reitz. 

Rosetta Rietz was a feminist, historian, and producer who recognized the absence of female voices within the jazz industry and sought to find the root cause. Through her efforts she quickly recognized that the women were there, they were simply unheard. Rosetta, determined to change this fact, began to collect information about the music of these women as a means of building a platform for them in Rosetta Records. This recording company was created for the sole purpose of promoting, rediscovering, and establishing the voices of women in the jazz industry, a rarity for the time period. With exactly 97 women under her records, Reitz was unwavering in her attempts to get their music picked up by major radio stations. Rosetta Records would go on to produce eighteen albums dedicated to many talented unknown singers and even some as big as Billie Holiday.  

From L to R: Tift Merritt, Annie Koppes and Anthony Kelley (Picture taken by Yasaman Baghban)

Rosetta was truly an influential creative whose influence extended beyond that of music. She was the owner of a bookstore in Greenwich Village. She went on to write one of the first books on menopause and on the absence of women in jazz.  She was an active member in her community seeking to recognize and correct injustices. Reitz was truly someone whose compassion and artistic empathy shone through. This is not to say that attempts at not centering herself were always successful. Reitz often faced backlash from the media for appearing disingenuous due to ethical and legal concerns surrounding her work. These concerns largely apply to works such as her Jailhouse Blues record which utilized the voices and struggles of women in a Mississippi prison, released by Mississippi congress, to create a record. Many questioned if these women consented to this, how they felt to find this, and the overall ethicality in creating this.  

Bass Connections team members Lindsay Frankfort and Trisha Santanam.

The legacy of Rosetta Reitz is one full of great passion and love for the art that is jazz and women’s place within it. The Bass Connections research team has managed to bring it to life by employing their own artistic empathy. They have created a full picture of the complexities, devotion and love Rosetta had for life’s work further cementing the fact that women indeed have a rightful place within the jazz industry.  

Post by Gabrielle Douglas, Class of 2027
Post by Gabrielle Douglas, Class of 2027

Soldier to Philanthropist: Abraham George’s Lasting Legacy at Shanti Bhavan

From his time in the Indian military to his journey to the NYU Stern School of Business to making his mark in India through his social work, Abraham George seems to be, and indeed is, a jack of all trades. He is the founder and principal of Shanti Bhavan, a school for students born into India’s lowest socioeconomic class.

“The last 29 years since I founded Shanti Bhavan, it has been the most rewarding and satisfying part of my life – I’ve done a lot of stuff, but nothing compares to what I’ve done with this,” George said. “The satisfaction comes from the fact that the children we have worked with are able to acquire jobs in Amazon and study in schools like Duke – one of them is here!” His words were infused with unmistakable passion. The crowd cheered the former student. We experienced a collective shiver down our spines; the fruit of George’s work was right in front of us – undeniable and beautiful.

The story of his life’s work was made into a Netflix documentary called “Daughters of Destiny.” Created and produced by Vanessa Roh, it featured the lives of students at the boarding school George founded. During his talk, we saw an ABC news segment called “Shanti Bhavan: haven of peace”.

After hearing the inspirations and motivations behind the creation of this boarding school, the designation of it being a ‘haven of peace’ is irrefutable.

George didn’t start in philanthropy. As an 18-year-old he found himself in the Indian military; he was posted near Tibet (in the Salem pass) where his job was to establish gun positions in case China invaded the country, India. In subzero temperatures, he lived through it for eleven months. During his time there, he read a quote ‘there is nothing right about war, it is about who is left’.

And so, George began asking himself questions: Why was he ready to take people’s lives? What was he truly doing with his life? And what would life be like in service of others?

He embarked on a newfound journey: to create a safe space where religion, caste or class does not matter. Today, Shanti Bhavan serves as a school for all – where students are not called ‘students’ but rather ‘children’.

A crucial question still stands: does the success of Shanti Bhavan prove the effectiveness of all charitable projects? When asked, George was quick to point out the fact that without money, there is no success. Consequently, his first goal was to earn, and second was to fund. Perhaps then all charitable causes could be effective if one has funding? It’s difficult to have a concrete answer, but it goes without saying that if it is true, George’s work serves as evidence.

George moved on from the life of a solider, to pursue education in the hopes of reaching a place where he could benefit others. “Think of a world only a heart can build and never ask why” – a memorable quote from a true benevolent force, akin to angelic presence.

Post by Noor Nazir, Class of 2027





Inventors, Assemble: The Newest Gadgets Coming Out of Duke

What do a smart toilet, an analog film app, and metamaterial computer chips have in common? They were all invented at Duke!

The Office for Translation & Commercialization—which supports Duke innovators bringing new technologies to market—recently hosted its fifth annual Invented at Duke celebration. With nine featured inventors and 300 attendees, it was an energetic atmosphere to network and learn.

Attendees mingle in Penn Pavilion. Credit: Brian Mullins Photography.

When event organizer Fedor Kossakovski was selecting booths, the name of the game was diversity—from medicine to art, from graduate students to faculty. “Hopefully people feel like they see themselves in these [inventors] and it’s representative of Duke overall,” he said. Indeed, as I munched through my second Oreo bar from the snack table and made the rounds, this diversity became apparent. Here are just two of the inventions on display:

Guided Medical Solutions

The first thing you’ll notice at Jacob Peloquin’s booth is a massive rubber torso.

As he replaces a punctured layer of rubber skin with a shiny new one, Peloquin beckons us over to watch. Using his OptiSETT device, he demonstrates easy insertion and placement of a chest tube.

“Currently, the method that’s used is you make an incision, and then place your fingers through, and then take the tube and place that between your fingers,” Peloquin explained. This results in a dangerously large incision that cuts through fascia and muscle; in fact, one-third of these procedures currently end in complications.

Peloquin’s device is a trocar—a thin plastic cylinder with a pointed tip at one end and tubing coming out of the other. It includes a pressure-based feedback system that tells you exactly how deep to cut, avoiding damage to the lungs or liver, and a camera to aid placement. Once the device is inserted, the outer piece can be removed so only the tubing remains.

Peloquin demonstrates his OptiSETT device. Credit: Brian Mullins Photography.

Peloquin—a mechanical engineering graduate student—was originally approached by the surgeons behind OptiSETT to assist with 3D printing. “They needed help, so I kind of helped those initial prototypes, then we realized there might be a market for this,” he said. Now, as he finishes his doctorate, he has a plethora of opportunities to continue working on OptiSETT full-time—starting a company, partnering with the Department of Defense, and integrating machine learning to interpret the camera feed.

It’s amazing how much can change in a couple years, and how much good a rubber torso can do.

GRIP Display

This invention is for my fellow molecular biology enthusiasts—for the lovers of cells, genes, and proteins!

The theme of Victoria Goldenshtein’s booth is things that stick together. It features an adorable claw machine that grabs onto its stuffed animal targets, and a lime green plastic molecule that can grab DNA. Although the molecule looks complex, Goldenshtein says its function is straightforward. “This just serves as a glue between protein and the DNA [that encodes it].”

Goldenshtein—a postdoctoral associate in biomedical engineering—uses her lime green molecular model to demonstrate GRIP’s function. Credit: Brian Mullins Photography.

Goldenshtein applies this technology to an especially relevant class of proteins—antibodies. Antibodies are produced by the immune system to bind and neutralize foreign substances like disease. They can be leveraged to create drug therapies, but first we need to know which gene corresponds to which antibody and which disease. That’s where GRIP steps in.

“You would display an antibody and you would vary the antibody—a billion different variations—and attach each one to the system. This grabs the DNA,” Goldenshtein said.

Then, you mix these billions of antibody-DNA pairs with disease cells to see which one attaches. Once you’ve found the right one, the DNA is readily available to be amplified, making an army of the same disease-battling antibody. Goldenshtein says this method of high-throughput screening can be used to find a cancer cure.

Although GRIP be but small, its applications are mighty.

Explore Other Booths

  • Coprata: a smart toilet that tracks your digestive health
  • inSoma Bio: a polymer that aids soft-tissue reconstruction
  • Spoolyard: a platform for exploring digital footage with analog film techniques
  • FaunaLabs: smart watches for our furry friends
  • G1 Optics: a tonometer to automatically detect eye pressure
  • TheraSplice: precision RNA splicing to treat cancer
  • Neurophos: metamaterial photonics for powering ultra-fast AI computation

As I finished my last Oreo bar and prepared for the trek back to East Campus, I was presented with a parting gift—a leather notebook with “Inventor” embossed on the cover. “No pressure,” said the employee who was handing them out with a wink.

I thought about the unique and diverse people I’d met that night—an undergraduate working in the Co-Lab, an ECE graduate student, and even a librarian from UNC—and smiled. As long as we each keep imagining and scribbling in our notebooks, there’s no doubt we can invent something that changes the world.

Post by Michelle Li, Class of 2027

Liam Frumkin and AHAV: Improving Lives Through Simple Snacks

We’re all familiar with the quintessential elementary school bake sale: hand-drawn posters, homemade treats, and shockingly high price tags, all in the name of charity. However, for Duke sophomore Liam Frumkin, his Few Quad bake sale resulted in a potential Shark Tank Product.

Liam Frumkin, Trinity '26
Liam Frumkin, Trinity ’26

Frumkin is a 20 year old economics major who recently got back from a gap year developing AHAV, a snack company specializing in healthy treats. AHAV, which means “to love” in Hebrew, has a mission statement “To Improve Lives Through Simple Snacks and Simple Ingredients!” Through selling healthy cookie dough bites and donating a portion of the proceeds to the National Eating Disorders Association (NEDA) and No Kid Hungry, Frumkin has been able to turn his bake sale into an amazing entrepreneurial venture. 

Frumkin’s story started seven years ago when he began to develop an eating disorder. Throughout his freshman and sophomore years of high school, Frumkin remembers losing unhealthy amounts of weight through constant exercise and eating very little. At grocery stores, he was overwhelmed by ingredient lists and nutritional contents of the snacks lining the aisles. 

His eating disorder came to its peak during his junior year, when he was hospitalized and began professional treatment for his eating disorder. Throughout treatment, Frumkin began to cook more in order to create snacks that both satisfied his cravings, and felt comfortable and safe to eat. At first, he says, Frumkin was doing this “just for [him]self”. 

When Frumkin arrived at Duke in August of 2021, he continued cooking in his dorm kitchens. Intrigued, his dorm-mates and friends would stop by to inquire and try Frumkin’s creations. Frumkin said he received stellar feedback about the nutritional value and deliciousness of his treats (I can confirm, having tried AHAV chocolate chip cookie dough bites, that they are, in fact, delicious). Because of his obsession with Shark Tank (I’m sure we can all relate), Frumkin began looking into how to capitalize on his passion of creating nutritional snacks. 

Liam and his very first batch of cookie dough bites.

And so, Frumkin began to hold bake sales in front of Few Quad on West Campus, selling ziploc bags of his homemade treats. Within a couple of months, he had made thousands of dollars, far surpassing my elementary school bake sales. When the Duke Administration caught wind of Frumkin’s bake sales, they informed him that the sale of foods without a license were illegal and encouraged him to find a professional kitchen.

Frumkin agreed with Duke and began searching for a professional kitchen, eventually finding a Duke alumnus who had started their own food business through an accelerator program called Union Kitchen. Union Kitchen accepts eight people a year and in exchange for 10% equity, allows access to kitchens, resources, and connections.

Frumkin applied to the program with zero expectations, not even telling his parents about his plans. However, after receiving the good news, his parents were nothing but supportive.

Liam and his parents in the AHAV kitchen.

With nothing but a few suitcases and ziploc bags of cookie dough bites, Frumkin began his semester off, moved to Washington D.C., and started work on AHAV. 

Pretty soon, a gap semester turned into a gap year, and Frumkin launched AHAV on January 1, 2023. At the time of the launch, Frumkin had already partnered with local retail stores to sell AHAV products in-store. When I talked with Frumkin, he expressed immense appreciation for Union Kitchen’s connections and their help getting his company off the ground.

Liam and the first bag of AHAV ever produced.

Frumkin turned to TikTok and Instagram to share his own journey with his eating disorder and to market AHAV, receiving resounding support from his followers, who resonated with both Frumkin’s story and AHAV’s mission. AHAV has more than 120,000 followers across various social media platforms and a team of six full-time employees based out of Washington D.C.

The AHAV logo

From applying for Shark Tank, to grocery stores like Trader Joe’s and Whole Foods, AHAV clearly has a bright future. AHAV has also donated over 120,000 meals to kids in need and helped over 6,000 kids get treatment for their eating disorders. Frumkin’s philanthropy has really lived up to AHAV’s meaning of “to love” and the heart-based logo. 

During his time-off, Frumkin found himself struggling with loneliness, having no consistent interactions with students his own age. Since he’s been back, Frumkin says he’s still searching for that perfect work-life-school balance. Despite this, he still says it is hands-down the smartest decision he’s ever made, which he largely credits to Duke’s support. During his time-off, Frumkin said Time Away From Duke was extremely supportive and accommodating. Since being back on campus, he’s reached out to the Innovation & Entrepreneurship Office and connected with fellow Duke students who are eager to help with video editing, marketing, etc. Frumkin also found support from Duke’s extensive alumni network, which he met through the pre-orientation group Project Edge, as well as the Duke in Silicon Valley program. 

Frumkin says that as a freshman, he still continued to struggle with disordered eating. He frequently met with a nutritionist from Duke Student Health, who he says was very helpful, specifically around his obsession with nutrients and ingredients. Frumkin stressed that students with eating disorders can fight their battles together. He says one of the most rewarding parts of starting AHAV has been sharing his journey and helping other people realize that they’re not alone. 

By Emily Zou, Class of 2027

How to be a Global Inventor

Gadgets, devices, doo-dads, oh my! The Duke Global Health Institute (DGHI)  recently hosted three of its members to lead a panel on creating medical devices for low- and middle-income countries. The event was called “Global Medical Device Innovation: Three Models for Creation and Commercialization.”

Each sought to decrease costs and increase scalability for medical procedures. In short, they are expert inventors who are doing good in the world. 

Two of the most prominent inventors of our era. Image courtesy of Disney.

We’ll go step-by-step in a moment, but to start you on your journey to being just like our panelists, here’s a short glossary:

Standard-of-care: a public health term for the way things are usually done.

IRB: institutional review board, a group of people, usually based in universities, that protect human subjects in research studies. 

Screening: when doctors look at signs your body might show to determine
whether you need to be tested for certain conditions. 

Supply-chain: the movement of materials your product goes through before, during, and after manufacturing. It is a general term for a group of different suppliers, factories, vendors, advertisers, researchers, and others that work separately. 

Regulatory pathways: supply-chain for government approvals and other paperwork you need to have before introducing your product to the public.

Step 1: Meet your Mentors

Walter Lee is Chief of Staff of the Department of Head and Neck Surgery & Communication Sciences, Co-Director of the Head and Neck Program, and an affiliate faculty member at the Duke Global Health Institute. He presented ENlyT (pronounced like en-light), a newfangled nasopharyngoscope – a camera that goes down your nose and down your throat to screen for cancer. He wants to expand with partners in Vietnam and Singapore. 

Marlee Kreiger helped found the Center for Global Women’s Health Technologies at Duke in 2007. Since then, she has led the Center in many interdisciplinary and international ventures. In fact, the Center for Global Women’s Health Technologies spans both the Pratt School of Engineering and the Trinity College of Arts and Sciences. She presented on the Callascope, a pocket-sized colposcope – a camera device for cervical cancer screening. 

Julias Mugaga will soon be a visiting scholar at Duke – until then, he heads Design Cube at Makerere University in Uganda. He presented his KeyScope, a plug-and-play surgical camera with 0.3% of the cost of standard-of-care cameras. 

Kreiger’s presentation slides

Step 2: Name your Audience

DGHI has “global” in the name, so it is no surprise that these presenters serve communities around the world. Perhaps something that inventors like Dr. Doofenshmirtz often get wrong is that new innovation should come at the benefit of underserved communities, not at the cost of them. For Lee, that focus would be in his collaborations in Vietnam; for Mugaga it was his community in Uganda; and for Kreiger, it was the many studies conducted in Zambia, Tanzania, Kenya, Costa Rica, Honduras, and India.

Each of the presenters could agree that the main strategy is simple: find partners. Community members on the ground. Organizations that can benefit from your presence.

Another prominent–albeit villainous–inventor, Dr. Doofenshmirtz. Image courtesy of Disney.

Another notable aspect of your audience will be the certification you vie for. Depending on your location, you may need different permissions to distribute your product, or even begin on the journey to secure funding from certain sources.

In the United States, the most relevant regulatory pathway is FDA clearance, which is notably less restrictive than the CE mark distributed in the European Union. Both certifications are accepted in other countries, but many of the inventors on the panel opted to secure a CE mark to potentially appeal to a wider variety of governments around the world.

ISO is an international organization that is also necessary for certification, particularly if you are looking to test a medical product. No reason to be dragged down by the paperwork, though! When asked about securing Ugandan product certification, Mugaga declared, “This is one of the most exciting journeys I have taken.” His path to clearance was even more wrought with uncertainty – without steady sources of material in the Ugandan economy, it is harder to earn FDA or CE approval, two of the most widely-acknowledged certifications in the world. 

Mugaga’s presentation slides

Step 3: Test 

Now that you have permission, you can start changing lives. Many participants in our panelists’ studies were patients in community health clinics across the globe. Their partners in these clinics also had the opportunity to save tens to hundreds of thousands of dollars in equipment. While it seems like a no-brainer, there are ethical concerns that need to be addressed first. For that, you need to fill out…. You guessed it: more paperwork. IRB approval is usually granted by educational institutions (as you should recall from my handy glossary), and is crucial to secure before any testing with humans is started. In fact, the government (and most private investors) won’t even give you a second glance if you ask them for money without IRB approval. 

One big hurdle many of the panelists noted was a distrust of the technology and institution it came from – a foreign entity testing their products on you does not always invoke fear, but it certainly does not always promote trust. Kreiger noted that the work of their community health partners does the heavy lifting on that front; not only are they known community pillars, but they have authority to promote health technology through their existing relationships. If you run into trouble identifying partners in your inventorship journey–never fear. Lee has a message for you: “Ask around. At Duke, there’s always an expert around who’s willing to lend you their time.”

Step 4: Distribute

Now that you are an expert, your invention works, and you’re saving lives, you can attempt to cement your design as standard-of-care. This may look different depending on where in the world you want to distribute, but the next step is to contract a large-scale manufacturer. Your materials have been sourced by now (FDA says they better be) — so finding someone to put them together at an industrial scale should be easy! Your cost may fluctuate at this scale with the increased labor costs, but bulk production and distribution altogether should provide you, your institution, and your clients the best possible chance at changing the world. 

Lee did not receive NIH funding until his fourth attempt at applying. Kreiger did not settle on the first manufacturer contracted. Mugaga is still in the process of securing a CE mark. And yet, all of them are success stories. You can see the ENlyT saving lives in hospitals in Vietnam; you can track the reallocation of $18,000 in savings from purchasing a Calloscope; and if you’re lucky, you’ll catch Mulgaga on campus next year as a visiting scholar at Duke!

Post by Olivia Ares, Class of 2025

New Blogger Michelle Li: Shrek, Minecraft, and Discovering New Things

My mom likes to introduce me by telling a childhood story. She’s told the same one for years, but it never fails to crack her up. (Watch out—she will genuinely cry from laughter!) It goes like this:

I was in second grade, and I was taking the ESL test. It’s straightforward—they show you flashcards, and you name them in English. I breezed through tree and house; but when I saw a bird, I fell silent.

“Don’t you know what a bird is?” my mom asked.

Cheeks red, I responded, “I knew it was a bird, I just wasn’t sure what species.”

At this point we’re both chortling, and she tells me that aiyah, Michelle, you were always so serious as a child.

That’s me on the left looking resolute at preschool graduation.

Which is a fair analysis—I was shy. I overthought. And I was a perfectionist. If I didn’t have the best answer or the most interesting remark, I was often too scared to speak at all.

But I love formulating answers, and I love talking to people. So going into high school, I told myself this mindset would change. I would shoot every shot and carpe every diem, fear be darned.

Like all new things, it was difficult. The learning curve was so steep it may as well have had a vertical asymptote. (If you liked that math joke, ask me about my calculus-themed promposal!)

Fortunately, life has a way of placing us in situations that help us grow. Sophomore year, I volunteered to teach STEM classes to middle schoolers. The chaos of pre-teens with pent-up quarantine energy is unparalleled—needless to say, I was terrified. But I found solace in the familiarity of science—as I rambled about CRISPR-Cas9 and coral ecology, I became more comfortable speaking to others.

I learned that Shrek is an icon, Minecraft is a competitive sport, and I should never click links in the Zoom chat—lest I be lured into a Rickroll. I also discovered that it didn’t matter whether my presentation was perfect or even if I acted a little weird.

Zooming with my middle school STEM buddies—note the Elmo background.

What mattered was watching students who’d never heard of engineering before prototyping egg parachutes and Rube Goldberg machines. What mattered was seeing Vicky return for a second year, evolving from student to TA. What mattered was watching a kid’s face light up with the joy of learning something new.

That’s what I hope to accomplish with the Duke Research Blog. As a freshman, I know the endless possibilities on campus—while a blessing—can be intimidating. STEM and academia have seemingly high barriers to entry. But I’ve also seen that discovering something new can be the best feeling in the world. I hope to play a small part in helping you, the reader, get there.

And as a baby Dukie, I hope to connect with the inspiring community here. Whether through a Research Blog interview or a quick conversation on the crowded C1, I am so excited to meet y’all.

So, if you see me around campus, come say hello! And if you’re a people-person-but-introverted like me and could use a conversation starter, here are a couple:

  • Tell me what songs you’re jamming to! I’m currently looping Gracie Abrams and Wallows. Debussy and Tchaikovsky are also regulars—String Quartet No. 1 goes so hard.
  • Talk about football! As a lifelong Cincinnatian, Joe Burrow is our king.
  • Share whatever you’re working on! Whether it be uber-complicated math (shoutout to Nikhil) or the perfect matcha latte (shoutout to Krishna), I’d love to know what you’re experimenting with.

Until then, remember to stay hydrated and keep discovering new things. ☺️

Post by Michelle Li, Class of 2027

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