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Putting Stronger Guardrails Around AI

AI regulation is ramping up worldwide. Duke AI law and policy expert Lee Tiedrich discusses where we’ve been and where we’re going.
AI regulation is ramping up worldwide. Duke AI law and policy expert Lee Tiedrich discusses where we’ve been and where we’re going.

DURHAM, N.C. — It’s been a busy season for AI policy.

The rise of ChatGPT unleashed a frenzy of headlines around the promise and perils of artificial intelligence, and raised concerns about how AI could impact society without more rules in place.

Consequently, government intervention entered a new phase in recent weeks as well. On Oct. 30, the White House issued a sweeping executive order regulating artificial intelligence.

The order aims to establish new standards for AI safety and security, protect privacy and equity, stand up for workers and consumers, and promote innovation and competition. It’s the U.S. government’s strongest move yet to contain the risks of AI while maximizing the benefits.

“It’s a very bold, ambitious executive order,” said Duke executive-in-residence Lee Tiedrich, J.D., who is an expert in AI law and policy.

Tiedrich has been meeting with students to unpack these and other developments.

“The technology has advanced so much faster than the law,” Tiedrich told a packed room in Gross Hall at a Nov. 15 event hosted by Duke Science & Society.

“I don’t think it’s quite caught up, but in the last few weeks we’ve taken some major leaps and bounds forward.”

Countries around the world have been racing to establish their own guidelines, she explained.

The same day as the US-led AI pledge, leaders from the Group of Seven (G7) — which includes Canada, France, Germany, Italy, Japan, the United Kingdom and the United States — announced that they had reached agreement on a set of guiding principles on AI and a voluntary code of conduct for companies.

Both actions came just days before the first ever global summit on the risks associated with AI, held at Bletchley Park in the U.K., during which 28 countries including the U.S. and China pledged to cooperate on AI safety.

“It wasn’t a coincidence that all this happened at the same time,” Tiedrich said. “I’ve been practicing law in this area for over 30 years, and I have never seen things come out so fast and furiously.”

The stakes for people’s lives are high. AI algorithms do more than just determine what ads and movie recommendations we see. They help diagnose cancer, approve home loans, and recommend jail sentences. They filter job candidates and help determine who gets organ transplants.

Which is partly why we’re now seeing a shift in the U.S. from what has been a more hands-off approach to “Big Tech,” Tiedrich said.

Tiedrich presented Nov. 15 at an event hosted by Duke Science & Society.

In the 1990s when the internet went public, and again when social media started in the early 2000s, “many governments — the U.S. included — took a light touch to regulation,” Tiedrich said.

But this moment is different, she added.

“Now, governments around the world are looking at the potential risks with AI and saying, ‘We don’t want to do that again. We are going to have a seat at the table in developing the standards.’”

Power of the Purse

Biden’s AI executive order differs from laws enacted by Congress, Tiedrich acknowledged in a Nov. 3 meeting with students in Pratt’s Master of Engineering in AI program.

Congress continues to consider various AI legislative proposals, such as the recently introduced bipartisan Artificial Intelligence Research, Innovation and Accountability Act, “which creates a little more hope for Congress,” Tiedrich said.

What gives the administration’s executive order more force is that “the government is one of the big purchasers of technology,” Tiedrich said.

“They exercise the power of the purse, because any company that is contracting with the government is going to have to comply with those standards.”

“It will have a trickle-down effect throughout the supply chain,” Tiedrich said.

The other thing to keep in mind is “technology doesn’t stop at borders,” she added.

“Most tech companies aren’t limiting their market to one or two particular jurisdictions.”

“So even if the U.S. were to have a complete change of heart in 2024” and the next administration were to reverse the order, “a lot of this is getting traction internationally,” she said.

“If you’re a U.S. company, but you are providing services to people who live in Europe, you’re still subject to those laws and regulations.”

From Principles to Practice

Tiedrich said a lot of what’s happening today in terms of AI regulation can be traced back to a set of guidelines issued in 2019 by the Organization for Economic Cooperation and Development, where she serves as an AI expert.

These include commitments to transparency, inclusive growth, fairness, explainability and accountability.

For example, “we don’t want AI discriminating against people,” Tiedrich said. “And if somebody’s dealing with a bot, they ought to know that. Or if AI is involved in making a decision that adversely affects somebody, say if I’m denied a loan, I need to understand why and have an opportunity to appeal.”

“The OECD AI principles really are the North Star for many countries in terms of how they develop law,” Tiedrich said.

“The next step is figuring out how to get from principles to practice.”

“The executive order was a big step forward in terms of U.S. policy,” Tiedrich said. “But it’s really just the beginning. There’s a lot of work to be done.”

Robin Smith
By Robin Smith

New Blogger Noor Nazir: Mental Health With a Pakistani Twist

My name is Door but replace the ‘D’ with an ‘N’.

Yes, I’m Noor and yes again, that is exactly how I introduced my freshman self to everyone in my year. Before you wonder, it’s an Arabic name and no I’m not from the Middle East! I’m a die-hard Pakistani with an overwhelming – and embarrassing – amount of love for Taylor Swift and Local Pakistani Music (stream Talha Anjum, you’ll be surprised!).

My personality mainly encompasses my thirteen-month-old niece, Alaya. I like to think she’s my mini doppelganger (she is not) and the last eight months of my life have been encapsulated by her cute presence, smelly diapers and charming smile. We spend most of our time listening to Taylor Swift, and – sometimes – the nursery rhyme, One Little Finger.  Other times, we play the guitar and sing for fun (your average Duke freshman).

Although, contrary to the ‘average Duke freshman’ who is sure about the trajectory of their next twenty years, I am not – at all. I find my mind wandering to several distinct fields of interest; whenever a classmate asks me “but where is your mind really at?”, my deliberate and circumspect answer is always “four to be exact: economics, political science, psychology and public policy”’. This answer is invariably met by an overt facial expression screaming their internal thought “oh so she’s really not sure”. But that side eye is beside the point since that uncertainty is precisely what led me to the Duke Research Blog.

In high school, whether it was the debate club or my interest in mental health, I always found a research angle to it. For debate, I’d research different case studies in order to formulate argumentation and rebuttals; for mental health, I’d utilize such case studies and would recreate what worked. My proudest creation, the Safe Space Society (a society in my alma matter, International School Lahore), was nothing short of a camaraderie and a community fostered with love and empathy. In my eyes, such a creation was only made possible because of extensive and life-long research by dedicated professionals.

Not only is research the perfect way to navigate my interests in a fulfilling manner, but it also acts as the tunnel vision to a transfigured world. Since my navigation wishes to find its destination in a declared major, I’m incredibly excited to write and learn about research revolving science, mental health, and anything Duke brings my way.

I am, however, most excited to translate and decode complex and seemingly mundane ideas in a nuanced and amusing way. The blog seems to be on a mission to make potential engineers excited about the next big thing in mental health research; this is a mission I’m excited and honored to take part in.  To sum it up, my goal at Duke Research Blog is to attend the research events you don’t want to and then write about them to make you regret not attending those events!

– A serious warning: you will see me bringing a Pakistani twist to every article I write! It’s just what us Pakistanis do (for a sample look at the sentence above). –

Noor Nazir, Class of 2027
Noor Nazir, Class of 2027

Helping People and Wildlife Coexist in Ways That Benefit Both, Using Math

Duke team wins top prize in mathematical modeling contest


Safari-goers watch a pride of lions in the Maasai Mara, a famous game reserve in Kenya. Credit: Ray in Manila, CC BY 2.0 via Wikimedia Commons
Safari-goers watch a pride of lions in the Maasai Mara, a famous game reserve in Kenya. Credit: Ray in Manila, CC BY 2.0 via Wikimedia Commons

Of all the math competitions for college students, the annual Mathematical Contest in Modeling (MCM) is one of the biggest. And this year, Duke’s team took home a coveted top prize.

Undergraduates Erik Novak, ’24, Nicolas Salazar, ’23, and Enzo Moraes Mescall, ’24, represented the Blue Devils at this year’s contest, a grueling 4-day event where teams of undergraduates use their mathematical modeling skills to solve a real-world problem. The results are finally in, and the Duke team was chosen as one of the top 22 outstanding winners out of more than 11,200 teams worldwide.

Their task: to analyze some of the challenges facing a nature reserve in Kenya known as the Maasai Mara. This region is named for the local Maasai people, a tribe of semi-nomadic people who make a living by herding cattle. It’s also teeming with wildlife. Each year, more than a million wildebeests, zebras and gazelles travel in a loop from neighboring Tanzania into Kenya’s Maasai Mara Reserve and back, following the seasonal rains in search of fresh grass to eat.

Some 300,000 safari-goers also flock to the area to witness the massive migration, making it a major player in Kenya’s billion-dollar tourism industry. But protecting and managing the land for the benefit of both wildlife and people is a delicate balancing act.

The reserve relies on tourism revenue to protect the animals that live there. If tourism slumps — due to political unrest in Kenya, or the COVID-19 pandemic — desperate communities living around the park resort to poaching to get by, threatening the very wildlife that tourism depends on.

Poachers aren’t the only problem: wild animals such as lions, leopards and elephants sometimes venture into human settlements in search of food. Conservationists must strike a balance between protecting these animals and managing the dangers they pose by raiding crops or killing valuable domestic livestock.

Tourism is a mixed blessing, too. While safari-goers bring money into the region, they can also disturb the animals and pollute the Mara River, and off-road drivers can erode the soil with their jeeps.

The mission facing the Duke team was to identify ways to mitigate such conflicts between wildlife and people.

From left: Teammates Erik Novak, ’24, Nicolas Salazar, ’23, and Enzo Moraes Mescall ’24 finished in the top 0.1% in the 2023 Mathematical Contest in Modeling.

This year’s contest ran over a single weekend in February. Camped out on the third floor of Perkins library, the team of three worked 12 hours a day, fueled by a steady supply of Red Bull and poke bowls. During that time, they built a model, came up with budget and policy recommendations, and wrote a 25-page report for the Kenyan Tourism and Wildlife Committee, all in less than 96 hours.

They built a mathematical model consisting of a system of six ordinary differential equations. According to the model’s predictions, they said, it should theoretically be possible to increase the reserve’s animal populations by about 25%, reduce environmental degradation by 20%, nearly eliminate retaliatory lion killings, and cut poaching rates in half — all while increasing the average yearly flow of tourists by 7.5%.

Participating in a smaller-but-similar contest last fall, the Triangle Competition in Mathematical Modeling, helped them prepare. “It’s kind of like a practice for the MCM,” Salazar said.

Veronica Ciocanel

“They did not win that contest, but they took everything they learned and look what they did with it. I’m very proud,” said assistant professor of mathematics and biology Veronica Ciocanel, who coached the team and co-organized the Triangle competition.

In addition to finishing in the top 0.1% of competitors, the Duke team got three additional awards for their performance; the Mathematical Association of America (MAA) award, the Society for Industrial and Applied Mathematics (SIAM) prize, and an International COMAP Scholarship Award of $10,000.

The problems in these contests tend to be much more open-ended than typical coursework. “We didn’t know what the solution was supposed to be or what tools to use,” Novak said.

Modeling, computation and coding skills are certainly important, Ciocanel said. “But really what matters more is practice, teamwork, and communicating their results in a written report. Students who have a solid course background don’t need to do anything else to prepare, they just need to be creative about using what they know from the courses they already took.”

“Use what you have and work well together,” Ciocanel said. “That I think is the most important thing.”

Robin Smith
By Robin Smith

What does it take to be a successful PhD student? Two grad students in statistics weigh in

With so many different career options in life, how do you know that you’ve found the right one for you?

Graduate students Edric Tam and Andrew McCormack, when asked what they hope to be doing in ten years, said they’d choose to do exactly the kind of work they’re doing right now – so clearly, they’ve found the right path. Tam, who obtained his undergraduate degree in Biomedical Engineering, Neuroscience and Applied Mathematics from Johns Hopkins University, and McCormack, who came from the University of Toronto with a degree in Statistics, are now 5th-year PhD students in the Department of Statistical Sciences. Tam works with Professor David Dunson, while McCormack works with Professor Peter Hoff, and both hope to pursue research careers in statistics.

Edric Tam
Andrew McCormack

Research interests

For the past five years, McCormack has been doing more theoretical research, looking at how geometry can lend insights into statistical models. The example he gives is of the Fisher information matrix, a statistical model that many undergraduate statistics majors learn in their third or fourth year.

Tam, meanwhile, looks at data with unique graphical and connectivity structures that aren’t quite linear or easily modeled, such as a brain connectome or a social network. In doing so, he works on answering two questions – how can you model data like this, and how can you leverage the unique structure of the data in the process?

What both Tam and McCormack like about the field of statistics is that, as Tam puts it, “you get to play in everyone’s backyard.” Moreover, as McCormack says, the beauty of theoretical research is that, while it’s certainly more time-consuming and incremental, it is often timeless, giving insight into something previously unknown.

On walking the research path

What does it take to be a successful PhD student? Both McCormack and Tam agree that a PhD is just a degree – anyone can get one if you work hard. But what sustains both through a career in research is a passion for what they do. Tam says that “you need inherent motivation, curiosity, passion, and drive.” McCormack adds that it helps if you work on problems that are interesting to you. 

Tam, who spent some time in a biomedical engineering lab during his undergraduate years, remembers reading about math and statistics the entire time he was there, which signaled to him that maybe, biomedical engineering wasn’t for him. McCormack’s defining moment occurred in the proof-based classes he took while as an undergraduate. He initially wanted to pursue a career in finance, but he quickly became enamored by the elegant precision of mathematical proofs – “even if all you’re proving is that 1+1=2!”

“You need inherent motivation, curiosity, passion, and drive.”

Edric tam, on what it takes to pursue a career in research

Even with passion for what you do, however, research can have its ups and downs. McCormack describes the rollercoaster of coming up with a new idea, convinced that “this is a paper right here”, and then a day later, after he’s had time to think about the idea, realizing that it isn’t quite up to the mark. Tam, who considers himself a pretty laidback person, sometimes finds the Type A personalities in research, as in any career field, too intense. Both McCormack and Tam prefer to not take themselves too seriously, and both exude a love for – and a trust of – the process.

Tam, not taking himself too seriously

Reflections on the past and the future

Upon graduation, McCormack will move to Germany to pursue a post-doc before beginning a job as Assistant Professor in Statistics at the University of Alberta. Tam will continue his research at Duke before applying to post-doc programs. In reflecting on their paths that have brought them till now, both feel content with the journey they’ve taken.

Tam sees the future in front of him – from PhD to post-doc to professorship – as “just a change in the title, with more responsibility”, and is excited to embark on his post-doc, where he gets to continue to do the research he loves. “It doesn’t get much better than this,” he laughs, and McCormack agrees. When McCormack joins the faculty at the University of Alberta, he’s looking forward to mentoring students in a much larger capacity, although he comments that the job will probably be challenging and he’s expecting to feel a little bit of imposter syndrome as he settles in.

When asked for parting thoughts, both Tam and McCormack emphasize that the best time to get into statistics and machine learning is right now. The advent of ChatGPT, for example, could replace jobs and transform education. But given their love for the field, this recommendation isn’t surprising. As Tam succinctly puts it, “given a choice between doing math and going out with friends, I would do math –  unless that friend is Andy!”

Post by Meghna Datta, Class of 2023

When Art and Science Meet as Equals

Artists and scientists in today’s world often exist in their own disciplinary silos. But the Laboratory Art in Practice Bass Connections team hopes to rewrite this narrative, by engaging Duke students from a range of disciplines in a 2-semester series of courses designed to join “the artist studio, the humanities seminar room, and the science lab bench.” Their work culminated in “re:process” – an exhibition of student artwork on Friday, April 28, in the lobby of the French Family Science Center. Rather than science simply engaging artistic practice for the sake of science, or vice versa, the purpose of these projects was to offer an alternate reality where “art and science meet as equals.”

The re:process exhibition

Liuren Yin, a junior double-majoring in Computer Science and Visual and Media Studies, developed an art project to focus on the experience of prosopagnosia, or face blindness. Individuals with this condition are unable to tell two distinct faces apart, including their own, often relying on body language, clothing, and the sound of a person’s voice to determine the identity of a person. Using her experience in computer science, she developed an algorithm that inputs distinct faces and outputs the way that these faces are perceived by someone who has prosopagnosia.

Yin’s project exploring prosopagnosia

Next to the computer and screen flashing between indistinguishable faces, she’s propped up a mirror for passers-by to look at themselves and contemplate the questions that inspired her to create this piece. Yin says that as she learned about prosopagnosia, where every face looks the same, she found herself wondering, “how am I different from a person that looks like me?” Interrogating the link between our physical appearance and our identity is at the root of Yin’s piece. Especially in an era where much of our identity exists online and appearance can be curated any way one wants, Yin considers this artistic piece especially timely. She writes in her program note that “my exposure to technologies such as artificial intelligence, generative algorithms, and augmented reality makes me think about the combination and conflict between human identity and these futuristic concepts.”

Eliza Henne, a junior majoring in Art History with a concentration in Museum Theory and Practice, focused more on the biological world in her project, which used a lavender plant in different forms to ask questions like “what is truthful, and what do we consider real?” By displaying a live plant, an illustration of a plant, and pressings from a plant, she invites viewers to consider how every rendition of a commonly used model organism in scientific experiments omits some information about the reality of the organism.

Junior Eliza Henne

For example, lavender pressings have materiality, but there’s no scent or dimension to the plant. A detailed illustration is able to capture even the way light illuminates the thin veins of the leaf, but is merely an illustration of a live being. The plant itself, which is conventionally real, can only further be seen in this sort of illustrative detail under a microscope or in a diagram.

In walking through the lobby of FFSC, where these projects and more are displayed, you’re surrounded by conventionally scientific materials, like circuit boards, wires, and petri dishes, which, in an unusual turn of events are being used for seemingly unscientific endeavors. These endeavors – illustrating the range of human emotion, showcasing behavioral patterns like overconsumption, or demonstrating the imperfection inherent to life – might at first glance feel more appropriate in an art museum or a performing arts stage.

But the students and faculty involved in this exhibition see that as the point. Maybe it isn’t so unnatural to build a bridge between the arts and the sciences – maybe, they are simply two sides of the same coin.

Post by Meghna Datta, Class of 2023

Meet Some of the Teams at the Bass Connections Showcase

If you weren’t outside enjoying the sun on Wednesday, April 19, you were probably milling around Penn Pavilion, a can of LaCroix in hand, taking in the buzz and excited chatter of students presenting at the 2023 Fortin Foundation Bass Connections Showcase.

Open floor presentations at the 2023 Bass Connections Showcase

This annual celebration of Bass Connections research projects featured more than 40 interdisciplinary teams made up of Duke faculty, graduate students, undergraduate students, and even partners from other research institutions.

Research teams presented posters and lightning talks on their findings. You might have heard from students aiming to increase representation of women in philosophy; or perhaps you chatted with teams researching physiotherapy in Uganda or building earthquake warning systems in Nepal. Below, meet three such teams representing a wide variety of academic disciplines at Duke.

Building sustainable university-community partnerships

As Bass Connections team member Joey Rauch described, “this is a poster about all of these other posters.” Rauch, who was presenting on behalf of his team, Equitable University-Community Research Partnerships, is a senior double-majoring in Public Policy and Dance. His interest in non-profit work led him to get involved in the team’s research, which aims to offer a framework for ethical and effective university-community research collaboration – exactly what teams do in Bass Connections. The group looked at complicated factors that can make equitable relationships difficult, such as university incentive structures, power dynamics along racial, socioeconomic, and ethnic lines, and rigid research processes.

Senior Joey Rauch with his team’s 2nd-place poster!

Along the lines of rigid research, when asked about what his favorite part of Bass Connections has been, Rauch remarked that “research is oddly formal, so having a guiding hand through it” was helpful. Bass Connections offers an instructive, inclusive way for people to get involved in research, whether for the first or fourth time. He also said that working with so many people from a variety of departments of Duke gave him “such a wealth of experience” as he looks to his future beyond Duke.

For more information about the team, including a full list of all team members, click here.

Ensuring post-radiation wellness for women

From left to right: seniors Danica Schwartz, Shernice Martin, Kayle Park, and Michelle Huang

Seniors Michelle Huang, Shernice Martin, Kayle Park, and Danica Schwartz (all pictured) were gathered around the poster for their team, Promoting Sexual Function and Pelvic Health in Women’s Healthcare.

The project has been around for three years and this year’s study, which looked at improving female sexual wellness after pelvic radiation procedures, was in fact a sister study to a study done two years prior on reducing anxiety surrounding pelvic exams.

As Huang described, graduate students and faculty conducted in-depth interviews with patients to better understand their lived experiences. This will help the team develop interventions to help women after life events that affect their pelvic and sexual health, such as childbirth or cancer treatment. These interventions are grounded in the biopsychosocial model of pain, which highlights the links between emotional distress, cognition, and pain processing.

For more information about the team, including a full list of all team members, click here.

From dolphins to humans

Sophomores Noelle Fuchs and Jack Nowacek were manning an interactive research display for their team, Learning from Whales: Oxygen, Ecosystems and Human Health. At the center of their research question is the condition of hypoxia, which occurs when tissues are deprived of an adequate oxygen supply.

Sophomores Noelle Fuchs and Jack Nowacek

Hypoxia is implicated in a host of human diseases, such as heart attack, stroke, COVID-19, and cancer. But it is also one of the default settings for deep-diving whales, who have developed a tolerance for hypoxia as they dive into the ocean for hours while foraging.

The project, which has been around for four years, has two sub-teams. Fuchs, an Environmental Science and Policy major, was on the side of the team genetically mapping deep-diving pilot whales, beaked whales, and offshore bottlenose dolphins off the coast of Cape Hatteras  to identify causal genetic variants for hypoxia tolerance within specific genes. Nowacek, a Biology and Statistics double-major, was on the other side of the research, analyzing tissue biopsies of these three cetaceans to conduct experiences on hypoxia pathways.  

The team has compiled a closer, more interactive look into their research on their website.

And when asked about her experience being on this team and doing this research, Fuchs remarked that Bass Connections has been a  “great way to dip my toe into research and figure out what I do and don’t want to do,” moving forward at Duke and beyond.

For more information about the team, including a full list of all team members, click here.

Post by Meghna Datta, Class of 2023

Senior Jenny Huang on her Love for Statistics and the Scientific Endeavor

Statistics and computer science double major Jenny Huang (T’23) started Duke as many of us do – vaguely pre-med, undecided on a major – but she knew she had an interest in scientific research. Four years later, with a Quad Fellowship and an acceptance to MIT for her doctoral studies, she reflects on how research shaped her time at Duke, and how she hopes to impact research.

Jenny Huang (T’23)

What is it about statistics? And what is it about research?

With experience in biology research during high school and during her first year at Duke, Huang toyed with the idea of an MD/PhD, but ultimately realized that she might be better off dropping the MD. “I enjoy figuring out how the world works” Huang says, and statistics provided a language to examine the probabilistic and often unintuitive nature of the world around us.

In another life, Huang remarked, she might have been a physics and philosophy double major, because physics offers the most fundamental understanding of how the world works, and philosophy is similar to scientific research: in both, “you pursue the truth through cyclic questioning and logic.” She’s also drawn to engineering, because it’s the process of dissecting things until you can “build them back up from first principles.”

At the International Society for Bayesian Analysis summer conference in Montreal

Huang’s research and the impact of COVID-19

For Huang, research started her first year at Duke, on a Data+ team, led by Professor Charles Nunn, studying the variation of parasite richness across primate species. To map out what types of parasites interacted with what type of monkeys, the team relied on predictors such as body mass, diet, and social activity, but in the process, they came up against an interesting phenomenon.

It appeared that the more studied a primate was, the more interactions it would have with parasites, simply because of the amount of information available on the primate. Due to geographic and experimental constraints, however, a large portion of the primate-parasite network remained understudied. This example of a concept in statistics known as sampling bias was muddling their results. One day, while making an offhand remark about the problem to one of her professors (Professor David Dunson), Huang ended up arranging a serendipitous research match. It turned out that Dunson had a statistical model that could be applied to the problem Nunn and the Data+ team were facing.

The applicability of statistics to a variety of different fields enamored Huang. When COVID-19 hit, it impacted all of us to some degree, but for Huang, it provided the perfect opportunity to apply mathematical models to a rapidly-changing pandemic. For the past two summers, through work with Dunson on a DOMath project, as well as Professor Jason Xu and Professor Rick Durrett, Huang has used mathematical modeling to assess changes in the spread of COVID-19.

On inclusivity in research

As of 2018, just 28% of graduates in mathematics and statistics at the doctoral level identified as women. Huang will eventually be included in this percentage, seeing as she begins her Ph.D. at MIT’s Department of Electrical Engineering and Computer Science in the fall, working with Professor Tamara Broderick.

“When I was younger, I always thought that successful and smart people in academia were white men,” Huang laughed. But that’s not true, she emphasizes: “it’s just that we don’t have other people in the story.” As one of the few female-presenting people in her research meetings, Huang has often felt pressure to underplay her more, “girly” traits to fit in. But interacting with intelligent, accomplished female-identifying academics in the field (including collaborations with Professor Cynthia Rudin) reaffirms to her that it’s important to be yourself: “there’s a place for everyone in research.”

At the Joint Statistical Meetings Conference in D.C with fellow researcher Gaurav Parikh

Advice for first-years and what the future holds

While she can’t predict where exactly she’ll end up, Huang is interested in taking a proactive role in shaping the impacts of artificial intelligence and machine learning on society. And as the divide between academia and industry is becoming more and more gray, years from now, she sees herself existing somewhere in that space.

Her advice for incoming Duke students and aspiring researchers is threefold. First, Huang emphasizes the importance of mentorship. Having kind and validating mentors throughout her time at Duke made difficult problems in statistics so much more approachable for her, and in research, “we need more of that type of person!”

Second, she says that “when I first approached studying math, my impatience often got in the way of learning.” Slowing down with the material and allowing herself the time to learn things thoroughly helped her improve her academic abilities.

Being around people who have this shared love and a deep commitment for their work is just the human endeavor at its best.

Jenny huang

Lastly, she stresses the importance of collaboration. Sometimes, Huang remarked,“research can feel isolating, when really it is very community-driven.” When faced with a tough problem, there is nothing more rewarding than figuring it out together with the help of peers and professors.  And she is routinely inspired by the people she does research with: “being around people who have this shared love and a deep commitment for their work is just the human endeavor at its best.”

Post by Meghna Datta, Class of 2023

(Editor’s note: This is Jenny’s second appearance on the blog. As a senior at NC School of Science and Math, she wrote a post about biochemist Meta Kuehn.)

How Research Helped One Pre-med Discover a Love for Statistics and Computer Science

If you’re a doe-eyed first-year at Duke who wants to eventually become a doctor, chances are you are currently, or will soon, take part in a pre-med rite of passage: finding a lab to research in.

Most pre-meds find themselves researching in the fields of biology, chemistry, or neuroscience, with many hoping to make research a part of their future careers as clinicians. Undergraduate student and San Diego native Eden Deng (T’23) also found herself plodding a similar path in a neuroimaging lab her freshman year.

Eden Deng T’23

At the time, she was a prospective neuroscience major on the pre-med track. But as she soon realized, neuroimaging is done through fMRI. And to analyze fMRI data, you need to be able to conduct data analysis.

This initial research experience at Duke in the Martucci Lab, which looks at chronic pain and the role of the central nervous system, sparked a realization for Deng. “Ninety percent of my time was spent thinking about computational and statistical problems,” she explained to me. Analysis was new to her, and as she found herself struggling with it, she thought to herself, “why don’t I spend more time getting better at that academically?”

Deng at the Martucci Lab

This desire to get better at research led Deng to pursue a major in Statistics with a secondary in Computer Science, while still on the pre-med track. Many people might instantly think about how hard it must be to fit in so much challenging coursework that has virtually no overlap. And as Deng confirmed, her academic path not been without challenges.

For one, she’s never really liked math, so she was wary of getting into computation. Additionally, considering that most Statistics and Computer Science students want to pursue jobs in the technology industry, it’s been hard for her to connect with like-minded people who are equally familiar with computers and the human body.

“I never felt like I excelled in my classes,” Deng said. “And that was never my intention.” Deng had to quickly get used to facing what she didn’t know head-on. But as she kept her head down, put in the work, and trusted that eventually she would figure things out, the merits of her unconventional academic path started to become more apparent.

Research at the intersection of data and health

Last summer, Deng landed a summer research experience at Mount Sinai, where she looked at patient-level cancer data. Utilizing her knowledge in both biology and data analytics, she worked on a computational screener that scientists and biologists could use to measure gene expression in diseased versus normal cells. This will ultimately aid efforts in narrowing down the best genes to target in drug development. Deng will be back at Mount Sinai full-time after graduation, to continue her research before applying to medical school.

Deng presenting on her research at Mount Sinai

But in her own words, Deng’s most favorite research experience has been her senior thesis through Duke’s Department of Biostatistics and Bioinformatics. Last year, she reached out to Dr. Xiaofei Wang, who is part of a team conducting a randomized controlled trial to compare the merits of two different lung tumor treatments.

Generally, when faced with lung disease, the conservative approach is to remove the whole lobe. But that can pose challenges to the quality of life of people who are older, with more comorbidities. Recently, there has been a push to focus on removing smaller sections of lung tissue instead. Deng’s thesis looks at patient surgical data over the past 15 years, showing that patient survival rates have improved as more of these segmentectomies – or smaller sections of tissue removal – have become more frequent in select groups of patients.

“I really enjoy working on it every week,” Deng says about her thesis, “which is not something I can usually say about most of the work I do!” According to Deng, a lot of research – hers included – is derived from researchers mulling over what they think would be interesting to look at in a silo, without considering what problems might be most useful for society at large. What’s valuable for Deng about her thesis work is that she’s gotten to work closely with not just statisticians but thoracic surgeons. “Originally my thesis was going to go in a different direction,” she said, but upon consulting with surgeons who directly impacted the data she was using – and would be directly impacted by her results – she changed her research question. 

The merits of an interdisciplinary academic path

Deng’s unique path makes her the perfect person to ask: is pursuing seemingly disparate interests, like being a Statistics and Computer Science double-major on the pre-med, track worth it? And judging by Deng’s insights, the answer is a resounding yes.

At Duke, she says, “I’ve been challenged by many things that I wouldn’t have expected to be able to do myself” – like dealing with the catch-up work of switching majors and pursuing independent research. But over time she’s learned that even if something seems daunting in the moment, if you apply yourself, most, if not all things, can be accomplished. And she’s grateful for the confidence that she’s acquired through pursuing her unique path.

Moreover, as Deng reflects on where she sees herself – and the field of healthcare – a few years from now, she muses that for the first time in the history of healthcare, a third-party player is joining the mix – technology.

While her initial motivation to pursue statistics and computer science was to aid her in research, “I’ve now seen how its beneficial for my long-term goals of going to med school and becoming a physician.” As healthcare evolves and the introduction of algorithms, AI and other technological advancements widens the gap between traditional and contemporary medicine, Deng hopes to deconstruct it all and make healthcare technology more accessible to patients and providers.

“At the end of the day, it’s data that doctors are communicating to patients,” Deng says. So she’s grateful to have gained experience interpreting and modeling data at Duke through her academic coursework.

And as the Statistics major particularly has taught her, complexity is not always a good thing – sometimes, the simpler you can make something, the better. “Some research doesn’t always do this,” she says – she’s encountered her fair share of research that feels performative, prioritizing complexity to appear more intellectual. But by continually asking herself whether her research is explainable and applicable, she hopes to let those two questions be the North Stars that guide her future research endeavors.

At the end of the day, it’s data that doctors are communicating to patients.

Eden Deng

When asked what advice she has for first-years, Deng said that it’s important “to not let your inexperience or perceived lack of knowledge prevent you from diving into what interests you.” Even as a first-year undergrad, know that you can contribute to academia and the world of research.

And for those who might be interested in pursuing an academic path like Deng, there’s some good news. After Deng talked to the Statistics department about the lack of pre-health representation that existed, the Statistics department now has a pre-health listserv that you can join for updates and opportunities pertaining specifically to pre-med Stats majors. And Deng emphasizes that the Stats-CS-pre-med group at Duke is growing. She’s noticed quite a few underclassmen in the Statistics and Computer Science departments who vocalize an interest in medical school.

So if you also want to hone your ability to communicate research that you care about – whether you’re pre-med or not – feel free to jump right into the world of data analysis. As Deng concludes, “everyone has something to say that’s important.”

Post by Meghna Datta, Class of 2023

Student Researchers Share What They Know About AI and Health

The healthcare industry and academic medicine are excited about the potential for artificial intelligence — really clever computers — to make our care better and more efficient.

The students from Duke’s Health Data Science (HDS) and AI Health Data Science Fellowship who presented their work at the 2022 Duke AI Health Poster Showcase on Dec. 6 did an excellent job explaining their research findings to someone like me, who knows very little about artificial intelligence and how it works. Here’s what I learned:

Artificial intelligence is a way of training computer systems to complete complex tasks that ordinarily require human thinking, like visual categorization, language translation, and decision-making. Several different forms of artificial intelligence were presented that do healthcare-related things like sorting images of kidney cells, measuring the angles of a joint, or classifying brain injury in CT scans.

Talking to the researchers made it clear that this technology is mainly intended to be supplemental to experts by saving them time or providing clinical decision support.

Meet Researcher Akhil Ambekar

Akhil standing next to his poster “Glomerular Segmentation and Classification Pipeline Using NEPTUNE Whole Slide Images”

Akhil Ambekar and team developed a pipeline to automate the classification of glomerulosclerosis, or scarring of the filtering part of the kidneys, using microscopic biopsy images. Conventionally, this kind of classification is done by a pathologist. It is time-consuming and limited in terms of accuracy and reproducibility of observations. This AI model was trained by providing it with many questions and corresponding answers so that it could learn how to correctly answer questions. A real pathologist oversaw this work, ensuring that the computer’s training was accurate.

Akil’s findings suggest that this is a feasible approach for machine classification of glomerulosclerosis. I asked him how this research might be used in medicine and learned that a program like this could save expert pathologists a lot of time.

What was Akhil’s favorite part of this project? Engaging in research, experimenting with Python and running different models, trying to find what works best.

Meet Researcher Irene Tanner

Irene Tanner and her poster, “Developing a Deep Learning Pipeline to Measure the Hip-Knee-Ankle Angle in Full Leg Radiographs”

The research Irene Tanner and her team have done aims to develop a deep learning-based pipeline to calculate hip-knee-ankle angles from full leg x-rays. This work is currently in progress, but preliminary results suggest the model can precisely identify points needed to calculate the angles of hip to knee to ankle. In the future, this algorithm could be applied to predict outcomes like pain and physical function after a patient has a joint replacement surgery.

What was Irene’s favorite part of this project? Developing a relationship with mentor, Dr. Maggie Horn, who she said provided endless support whenever help was needed.

Meet Researcher Brian Lerner

Brian Lerner and his poster, “Using Deep Learning to Classify Traumatic Brain Injury in CT Scans”

Brian Lerner and his team investigated the application of deep learning to standardize and sharpen diagnoses of traumatic brain injury (TBI) from Computerized Tomography (CT) scans of the brain. Preliminary findings suggest that the model used (simple slice) is likely not sufficient to capture the patterns in the data. However, future directions for this work might examine how the model could be improved. Through this project, Brian had the opportunity to shadow a neurologist in the ER and speculated upon many possibilities for the use of this research in the field.

What was Brian’s favorite part of this project? Shadowing neurosurgeon Dr. Syed Adil at Duke Hospital and learning what the real-world needs for this science are.

Many congratulations to all who presented at this year’s AI Health Poster Showcase, including the many not featured in this article. A big thanks for helping me to learn about how AI Health research might be transformative in answering difficult problems in medicine and population health.

By Victoria Wilson, Class of 2023

COVID and Our Education

With mask mandates being overturned and numerous places going back to “normal,” COVID is becoming more of a subconscious thought. Now, this is not a true statement for the entire population, since there are people who are looking at the effects of the pandemic and the virus itself.

I attended a poster presentation for the “The Pandemic Divide” event hosted here at Duke by the Samuel Dubois Cook Center on Social Equity. To me, all the poster boards conveyed the theme of how COVID-19 had affected our lives in more ways than just our health. One connection that particularly caught my eye would be the one between American Education and COVID.

The poster for the conference

As a student who lived through COVID while attending high school, I can safely say that the pandemic has affected education. However, based on the posters I saw, it is important to know that education, too, has a strong and impactful impact on COVID-19.

Dr. Donald J. Alcendor after a great presentation

The first evidence I saw was from Donald J. Alcendor, an associate professor of microbiology and immunology at Meharry Medical College in Nashville. His poster was about the hesitancy surrounding COVID-19 vaccines. One way he and his team figured out to lessen the hesitance from the public was to improve the public’s trust. To achieve this, Alcendor and his team sent trusted messengers into the community. One of the types of messengers they provided was scientists who studied COVID-19. These scientists were able to bring factual information about the disease, how it spreads, and the best course of action to act against it. Alcendor and his research team also brought in “vaccine ambassadors” to the community and a mobile unit to help give the community vaccines. He noted that this was accomplished with support from the Bloomberg Foundation’s Greenwood Initiative, which addresses Black health issues.

With this mobile unit, Alcendor and his team were able to reach people and help those who were otherwise unable to receive help for themselves because of their lack of transportation. They provided people from all backgrounds with help and valuable information.

Alcindor said he and his team planned pop-up events based on where the community they were trying to reach congregates. With the African American community, he planned pop-up events at churches and schools. Then for the Latino community, he planned pop-events where families tend to gather, and he held events in Latin0 neighborhoods. In addition, he made sure that the information was available in Spanish at all levels, from the flyers and the surveys, to the vaccinators themselves.

All of these amenities that he and his group provided were able to educate the community about COVID-19 and improve their trust in the scientists working on the disease. Alcendor and his team were able to impact COVID-19 through education, and by going to the event, it was evident to me that he was not the only one who accomplished this.

Dr. Colin Cannonier and his poster

Colin Cannonier, an associate professor of economics at Belmont University in Nashville, asked and answered the question, “does education have an impact on COVID? Specifically, does it change health and wellbeing?” To answer this question, he researched how education about COVID can affect a person. He discovered that when a person is more educated about COVID, how it is spread, and its symptoms, they are more likely to keep the pandemic in check through their behavior. He came to this conclusion because he realized that when higher educated people know more about COVID, they exhibit behaviors to remain healthy, meaning that they would follow the health protocols given by the health officials.

While this may seem like common sense that the more educated a person is, the more they make smart choices pertaining to COVID, this shows how important education is and how deadly ignorance is. Cannonier’s research gave tangible evidence to show that education is a weapon against diseases. Unfortunately, it is evident that some officials did not believe in educating the public about the virus or the virus itself, and that proved to be extremely deadly.

To fully capture the relationship between COVID and education, one must also talk about how COVID-19 affected education.

Ms. Stacey Akines and her wonderful poster

Stacey Akines, a history graduate student at Carnegie Mellon University, studied how education was changed by the pandemic.

First, she realized that COVID schooling crossed over with homeschooling. Then she uncovered that more Black people started to research and teach their children about Black history. This desire to teach youth more about their history caused an increase in the number of Black homeschoolers. In fact, the number of Black homeschoolers doubled during the fall of 2020. While to some, this change to homeschooling may have a negative impact on one’s life, it actually gives the student more opportunities to learn things.

It is no secret that there are many books being banned here in the U.S., and there are many state curriculums that are changing to erase much of Black history. Homeschooling a child gives the parent an opportunity to ensure that the education they receive is true to and tells their history

Unlike me, where during high school, education felt lackluster and limited because of COVID, some parents saw an opportunity to better their child’s education.

A hall of Posters

I hope that it is clear that the relationship between COVID and education is a complex one. Both can greatly impact each other, whether it’s for the better or for the worse. COVID thrives when we are uneducated, and it very nearly destroyed education too, but for the efforts of some dedicated educators.

Post by Jakaiyah Franklin, Class of 2025

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