Following the people and events that make up the research community at Duke

Students exploring the Innovation Co-Lab

Category: Engineering Page 1 of 14

Farmers, Crops…and Computers?

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In Hanjie the rules are simple. In this game of logic and creativity, the players, often working on medium-sized grids of 225 squares, use numbers on the rows and columns as clues to determine which boxes to shade. At first, the prospect of seeing a beautiful picture seems almost unfathomable. However, through patience and collaboration from every corner of the page, these small seemingly random squares gradually come together to reveal a masterpiece—one square at a time. 

In a sense the efforts of Duke’s Climate Commitment are no different. The issue of climate change has proven to be a multifaceted one. One in which many parties play a role. However, with initiatives such as Duke’s Forever Learning Institute, the probability of tackling these issues becomes much clearer.

The logo of Duke’s Forever Learning Institute retrieved from their website.

Recently Duke’s Forever Learning Institute, an interdisciplinary educational program for Duke alumni, hosted Professors Norbert Wilson and Maiken Mikkelson for a compelling session on the impact of climate change on food and agriculture. Wilson, an agricultural economist and the Director of the World Food Policy Center at Duke, specializes in addressing critical issues related to food access, nutrition, and food security. Mikkelsen, a distinguished expert in physics, electrical, and computer engineering, explores the potential of nanomaterials to revolutionize agricultural processes, paving the way for innovative solutions in the field. Together, they explained how advancements in nanomaterials can improve food security and sustainability. 

Throughout the session, Wilson emphasized the concept of food security. He began by clarifying the difference between “food loss” and “food waste.”  Food loss occurs at the agricultural level. It refers to food that is produced but never reaches consumers, often due to challenges such as poor harvesting seasons, labor shortages for harvesting, or other natural factors. He describes the ways in which loss occurs across the board but disproportionately affects less developed countries. Wilson also explained how food waste occurs at the consumer level. He details how it goes beyond the waste of a product but is also a waste of the resources used to create that product. 

Picture of Professor Norbert Wilson. Photo retrieved from Duke Divinity School.

Wilson illustrated the significance of these issues by drawing out the larger issue of food insecurity. Food insecurity describes an inability to access food or concerns about accessing food. In the United States 13.5 percent of citizens struggle with accessing food. This can lead to a number of negative health outcomes such as cardiovascular issues and diabetes. Food insecurity can also lead to behavioral and performance issues, particularly in young children.

Infographic about food insecurity retrieved from ECOMERGE.

This is where Mikkelson comes in. She described a term known as Precision Agriculture. In this, researchers observe and measure agriculture fields and extra data to see what resources such as water, and fertilizer is needed at each part. In this, they hope to retrieve good information through wavelengths as a means of getting a spectral fingerprint that supplies information about the crops. Mikkelsen describes her interest in leveraging nanomaterials to create lightweight, cost-effective hyperspectral cameras capable of capturing detailed spectral fingerprints of crops. She hopes that these materials can be employed around the world, and low resource settings to increase crop yields. The greatest roadblock in this would be the price and issues with widespread application. However, once applied it would hold the ability to detect key characteristics such as nutrient deficiencies, water stress, or disease presence.

Duke Researchers working with Nanotechnology. Image retrieved from Duke Pratt School of Engineering.

Our world is wildly affected by climate change. Climate change and agricultural production hold a very dependent relationship and fixing one side holds the ability to correct the other. This is what makes the work and research of those such as Wilson and Mikelson all the more important. Their efforts show how we can utilize technology to not only enact social change but also reverse our climate issues. Their research highlights not only the urgency of addressing food security and agricultural sustainability but also the transformative potential of interdisciplinary approaches.

Just as the game of Hanjie reveals its masterpiece one square at a time, tackling climate change requires collective effort and patience. Each initiative, whether through advanced nanotechnology or policy-driven solutions, brings us closer to a sustainable future. Duke’s Forever Learning Institute serves as a platform to connect these ideas, inspiring action and innovation that can shape a better tomorrow—one step at a time.

Post by Gabrielle Douglas, Class of 2027
Post by Gabrielle Douglas, Class of 2027

‘Design Climate’ Students Pitch Solutions at Energy Week 2024

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Amid the constant drumbeat of campus events, much of the conversation turned toward the challenges we face in energy policy, security and transitions during Duke’s annual Energy Week, held Nov. 11-15.

On the second day, the Innovation Showcase featured not only startups making their pitches for clean energy and sustainable tech products, but students doing so as well. 

Currently in its second year, Duke Design Climate is a new initiative between the Pratt School of Engineering and the Nicholas School of the Environment. It functions as a two-course sequence, in which students form groups to prototype and promote climate solutions after conducting market research.

As I made my rounds to the teams, I met a mix of graduate students and undergraduates with academic backgrounds ranging from engineering to economics to environmental science. The ideas they have aren’t purely theoretical: all are looking for sponsors or partners to help implement their solutions into real-world use. Here were some of the highlights:    

Team ReefCycle is building from plants: Our first stop is named after the company whose product they intend to scale up. Initially, Mary Lempres founded ReefCycle to develop sustainable material for artificial reefs. Regular industrial production for cement requires intensive heating– burning of fossil fuels–releasing tons of carbon dioxide. ReefCycle sought to reduce this climate impact with a different method: their cement is plant-based and enzymatic, meaning its essentially grown using enzymes from beans. Testing in the New York Harbor yielded some promise: the cement appeared to resist corrosion, while becoming home for some oysters. The Design Climate team is now trying to bring it to more widespread use on land, while targeting up to a 90% reduction in carbon emissions across all scopes.

Team Enfield is uplifting a local community: Design Climate, evidently, is by no means limited to science. Instead, these team members intend to address an environmental justice issue close to home: energy inequality. Around 30-35% of Enfield residents live below the poverty line, and yet suffer from some of the highest energy bills in the larger area. Located a ninety minute drive east of Durham, this rural town is one of the poorest in North Carolina. Historic redlining and unfavorable urban planning are responsible for its lack of development, but now this team aims to bring back commerce to the area through microfinance. Once enough funding is gathered from investors and grants, the team hopes to provide microloans and financial literacy to spur and empower businesses. 

UNC Libraries Commons

Team Methamatic promotes a pragmatic e-methane solution: This team is harnessing the power of sunlight to drive fuel production. Synthetic methane, commonly referred to as e-methane, is produced by reacting green hydrogen and carbon dioxide. “Currently, the power-to-gas process can be carbon neutral,” said team member Eesha Yaqub, a senior. “Sourcing the recycled carbon dioxide from a carbon capture facility essentially cancels out the emissions from burning methane.” However, this power-to-gas (P2G) process is an intensive one requiring high heat, energy, and pressure–hoops that might not have to be jumped through if an alternative process could break through the market. Professor Jie Liu and the Department of Chemistry have been working on developing a reactor that would conduct this same reaction without those obstacles. “[Utilizing] the energy from ultraviolet light, which is absorbed by a catalyst …makes the process less energy intensive,” Yaqub said.

Right now, the team has a small prototype, but one used for commercial generation would appear much larger and cost between $15,000 to $20,000. Their intended customers? Oil and gas companies under pressure to shift away from fossil fuels. If successfully scaled up, they predict this process would produce e-methane at a price of $5 per kilogram. 

Analyzing living shorelines through Team Coastal Connect: If “Coastal Connect” sounds more like an app than a project name, that’s because it is one. This group is designing what one member dubbed a “fitbit for shorelines”: a monitoring system that brings data from ocean buoys to the phones of local landowners. While measurements in salinity and water level aren’t always telling for the average person, the app would contextualize these into more useful phrases. Is it currently safe to swim? It’ll let you know.

Moreover, it would also allow for the long-term monitoring of living shorelines. While we know this nature-based solution offers resilience to natural disasters and presents erosion, short-term fixes like seawalls are often built instead to continue allowing development up to the edge of beaches. The team hopes that ideally, providing concrete data on living shorelines would allow us to demonstrate their benefits and promote their implementation. 

By Crystal Han, Class of 2028

The Dukies Cited Most Highly

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The Web of Science ranking of the world’s most highly-cited scientists was released this morning, telling us who makes up the top 1 percent of the world’s scientists. These are the authors of influential papers that other scientists point to when making their arguments.

EDITOR’S NOTE! — Web of Science shared last year’s data! We apologize. List below is now corrected, changes to copy in bold. We’re so sorry.

Twenty-three of the citation laureates are Duke scholars or had a Duke affiliation when the landmark works were created over the last decade.

A couple of these Duke people disappeared from this year’s list, but we’re still proud of them.

Two names on the list belong to Duke’s international powerhouse of developmental psychology, the Genes, Environment, Health and Behavior Lab, led by Terrie Moffitt and Avshalom Caspi.

Dan Scolnic of Physics returns as our lone entry in Space Science, which just makes Duke sound cooler all around, don’t you think?

This is a big deal for the named faculty and an impressive line on their CVs. But the selection process weeds out “hyper-authorship, excessive self-citation and anomalous citation patterns,” so don’t even think about gaming it.

Fifty-nine nations are represented by the 6,636 individual researchers on this year’s list. About half of the citation champions are in specific fields and half in ‘cross-field’ — where interdisciplinary Duke typically dominates. The U.S. is still the most-cited nation with 36 percent of the world’s share, but shrinking slightly. Mainland China continues to rise, claiming second place with 20 percent of the cohort, up 2.5 percent from just last year. Then, in order, the UK, Germany and Australia round out the top five.

Tiny Singapore, home of the Duke NUS Graduate Medical School, is the tenth-most-cited with 1.6 percent of the global share.

In fact, five Duke NUS faculty made this year’s list: Antonio Bertoletti, Derek Hausenloy and Jenny Guek-Hong Low for cross-field; Carolyn S. P. Lam for clinical medicine, and the world famous “Bat Man,” Lin-Fa Wang, for microbiology.

Okay, you scrolled this far, let’s go!

Biology and Biochemistry

Charles A. Gersbach

Clinical Medicine

Christopher Bull Granger

Adrian F. Hernandez

Gary Lyman

Cross-Field

Priyamvada Acharya

Chris Beyrer

Stefano Curtarolo

Vance G. Fowler Jr.

Po-Chun Hsu (adjunct, now U. Chicago)

Ru-Rong Ji

William E. Kraus

David B. Mitzi

Christopher B. Newgard

Pratiksha I. Thakore (now with Genentech)

Xiaofei Wang

Mark R. Wiesner

Environment and Ecology

Robert B. Jackson (adjunct, now Stanford U.)

Microbiology

Barton F. Haynes

Neuroscience and Behavior

Quinn T. Ostrom

Plant and Animal Science

Sheng-Yang He

Psychiatry and Psychology

Avshalom Caspi

William E. Copeland

Terrie E. Moffitt

Space Science

Dan Scolnic

Sticking to Sweat: The Future of Biosensors and Tracking Our Health

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Bandaids and pimple patches are the first things we consider when discussing adhesives in medicine. But what if there is more to the story? What if adhesives could not only cover and protect but also diagnose and communicate? It turns out Dr. Wei Gao, assistant professor of medical engineering at the California Institute of Technology, is asking these exact questions. In the field of biomedical adhesives, Gao’s research is revolutionizing our understanding of precision medicine and medical testing accessibility. He visited Duke on Oct. 9 to present his work as part of the MEMS (Mechanical Engineering and Material Science) Seminar Series. 

Wei Gao presenting at Duke University

Gao’s research team focuses on material, device, and system innovations that apply molecular research and principles to clinical settings and improve health. Gao focused his talk on the invaluable characteristics and uses of sweat. Sweat can offer doctors a broad spectrum of information, including nutrients, biomarkers, pH levels, electrolytes/salts, and hormones. He leverages this fundamental characteristic of human physiology to design wearable biosensors that can provide early warnings of health issues or diseases. Gao focuses on making biomarker detection more efficient than current methods, such as blood samples, which require hospital testing, involve highly invasive techniques, and lack continuous monitoring. 

The first milestone in his research came in 2016 when he introduced a fully printed, wearable, real-time monitoring sensor device. The device allowed them to continuously collect sweat and wirelessly communicate data about these sweat samples from patients onto digital devices. The initial 2016 device focused on resolving four fundamental challenges: since most chemical sensors are not stable over long periods of time, the device had to be (1) low-cost and (2) disposable without sacrificing performance. In addition, the device had to (3) be mass-producible to be accessible to the public and (4) integrate multiple signals that could be real-time transmitted to a digital interface.  

Schematic of the sensor array for multiplexed perspiration analysis in Dr. Gao’s 2016 biosensor design

To address the first two of those challenges, Gao and his group turned to printing techniques.  The circuit substrate was a thin piece of flexible PET (a plastic), upon which they layered the circuit components.  The flexible sensor array was constructed in a similar pattern, with a layer of PET patterned with gold to produce the electrodes, covered with parylene, and then each electrode was tuned to receive a specific chemical stimulus: potassium and sodium ion sensors, with a polyvinyl butyrate reference electrode, and oxidase-based glucose and lactate sensors paired with a silver/silver chloride reference electrode.  This design allows the simultaneous monitoring of multiple biomarkers.  To transmit the data wirelessly, the circuit board included a Bluetooth transceiver.

The next major step was to devise a way to monitor sweat without relying upon heat or vigorous exercise, neither of which may be feasible in the case of clinically ill patients. In a 2023 paper, Gao and colleagues published a biosensor that could induce localized sweating using an electric circuit. Called iontophoresis, the technique delivers a drug (a cholinergic agonist) that stimulates the sweat glands on demand and only in the area of the sensor. 

Another important question was how to power the devices sustainably.  Gao’s lab has devised two primary responses to this question: In a 2020 paper, his team powered a similar multiplexed wireless sensor entirely using electricity generated from compounds in sweat. This entailed using lactate biofuel cells to harness the oxidation of lactate to pyruvate (coupled with the reduction of oxygen to water) to provide a stable current. In a 2023 paper, they employed a flexible perovskite solar cell onboard the device to power the monitoring of a suite of biomarkers.

Dr. Gao’s recent publication in February 2024 highlighted a Consolidated AI-Reinforced Electronic Skin (CARES) for stress response monitoring

With these technical hurdles overcome, Gao and his lab have been able to develop sensors targeted to several important medical applications. The work can be directly applied to the monitoring of conditions like cystic fibrosis and gout. More broadly, wearable biosensors can be used to track levels of medically relevant compounds like cortisol (for stress monitoring), C reactive protein (inflammation), and reproductive hormones. The lab has also branched into other kinds of devices that use similar microfluidics approaches, including smart bandages for wound monitoring and smart masks to detect biomarkers in breath.

Through eight years of dedicated investigation, Gao serves as a pioneer in the field of bioelectronic interfaces. Gao continues to widen the possibilities of biosensors not only within the medical sphere but also for the general public. For example, his lab is collaborating with NASA and the U.S. Navy to support the performance and health of astronauts and our military, which is vital as they work in extreme environments. By pushing forward ground-breaking devices such as sweat biosensors, our healthcare systems can pursue preventative care, reducing the need for treatments or health resources by catching these issues early on. Following Gao’s footsteps, we can now build toward a healthier future as we improve the precision of our healthcare approaches and technological advancements.

By Monona Zhou and Nicolás Zepeda

Duke experts discuss the potential of AI to help prevent, detect and treat disease

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Sure, A.I. chatbots can write emails, summarize an article, or come up with a grocery list. But ChatGPT-style artificial intelligence and other machine learning techniques have been making their way into another realm: healthcare.

Imagine using AI to detect early changes in our health before we get sick, or understand what happens in our brains when we feel anxious or depressed — even design new ways to fight hard-to-treat diseases.

These were just a few of the research themes discussed at the Duke Summit on AI for Health Innovation, held October 9 – 11.

Duke assistant professor Pranam Chatterjee is the co-founder of Gameto, Inc. and UbiquiTx, Inc. Credit: Brian Strickland

For assistant professor of biomedical engineering Pranam Chatterjee, the real opportunity for the large language models behind tools like ChatGPT lies not in the language of words, but in the language of biology.

Just like ChatGPT predicts the order of words in a sentence, the language models his lab works on can generate strings of molecules that make up proteins.

His team has trained language models to design new proteins that could one day fight diseases such as Huntington’s or cancer, even grow human eggs from stem cells to help people struggling with infertility.

“We don’t just make any proteins,” Chatterjee said. “We make proteins that can edit any DNA sequence, or proteins that can modify other disease-causing proteins, as well as proteins that can make new cells and tissues from scratch.”

Duke assistant professor Monica Agrawal is the co-founder of Layer Health. Credit: Brian Strickland

New faculty member Monica Agrawal said algorithms that leverage the power of large language models could help with another healthcare challenge: mining the ever-expanding trove of data in a patient’s medical chart.

To choose the best medication for a certain patient, for example, a doctor might first need to know things like: How has their disease progressed over time? What interventions have already been tried? What symptoms and side effects did they have? Do they have other conditions that need to be considered?

“The challenge is, most of these variables are not found cleanly in the electronic health record,” said Agrawal, who joined the departments of computer science and biostatistics and bioinformatics this fall.

Instead, most of the data that could answer these questions is trapped in doctors’ notes. The observations doctors type into a patient’s electronic medical record during a visit, they’re often chock-full of jargon and abbreviations.

The shorthand saves time during patient visits, but it can also lead to confusion among patients and other providers. What’s more, reviewing these records to understand a patient’s healthcare history is time-intensive and costly.

Agrawal is building algorithms that could make these records easier to maintain and analyze, with help from AI.

“Language is really embedded across medicine, from notes to literature to patient communications to trials,” Agrawal said. “And it affects many stakeholders, from clinicians to researchers to patients. The goal of my new lab is to make clinical language work for everyone.”

Duke assistant professor Jessilyn Dunn leads Duke’s BIG IDEAs Lab. Credit: Brian Strickland

Jessilyn Dunn, an assistant professor of biomedical engineering and biostatistics and bioinformatics at Duke, is looking at whether data from smartwatches and other wearable devices could help detect early signs of illness or infection before people start to have symptoms and realize they’re sick.

Using AI and machine learning to analyze data from these devices, she and her team at Duke’s Big Ideas Lab say their research could help people who are at risk of developing diabetes take action to reverse it, or even detect when someone is likely to have RSV, COVID-19 or the flu before they have a chance to spread the infection.

“The benefit of wearables is that we can gather information about a person’s health over time, continuously and at a very low cost,” Dunn said. “Ultimately, the goal is to provide patient empowerment, precision therapies, just-in-time intervention and improve access to care.”

Duke associate professor David Carlson. Credit: Brian Strickland

David Carlson, an associate professor of civil and environmental engineering and biostatistics and bioinformatics, is developing AI techniques that can make sense of brain wave data to better understand different emotions and behaviors.

Using machine learning to analyze the electrical activity of different brain regions in mice, he and his colleagues have been able to track how aggressive a mouse is feeling, and even block the aggression signals to make them more friendly to other mice.

“This might sound like science fiction,” Carlson said. But Carlson said the work will help researchers better understand what happens in the brains of people who struggle with social situations, such as those with autism or social anxiety disorder, and could even lead to new ways to manage and treat psychiatric disorders such as anxiety and depression.

Credit: Brian Strickland.
Robin Smith
By Robin Smith

Deep Dive into Engineering’s Past

Many of us enter the Duke library complex through the Rubenstein doors, especially on rainy days. However, despite passing countless times, most have never ventured into the Rubenstein Rare Book & Manuscript Library or checked out its artifacts – including some eye-catching items featured at the annual Engineering Expo on September 18.

How could I not start by describing the 16th-century amputation saw? The magnificent artifact was handled by many impressed visitors, including myself (see adjacent photo). The embroidery was exuberant, and Rachel Ingold, the Curator of the History of Medicine Collections, informed me that the saw was of European descent. She also pointed out that the blade is removable and appears different from the rest of the artifact, suggesting that the instrument has been so frequently used that the blade had to be replaced. I curiously asked whether historians know how many patients have been victimized by this gruesome, two-person saw… sadly, the answer is we don’t know. Merely the thought of the procedure makes me shudder.

Me holding the amputation blade… it should’ve been held by two people back in the day!


While the saw was the headline artifact, it was by no means the only spotlight! Brooke Guthrie, a Research Services Librarian staffing the event, suggested that I examine Robert Hooke’s “Micrographia,” her personal favorite. In particular, she pointed out the exquisite scientific illustration of a flea, which was recorded using an early microscope. The level of detail (such as the hairs and claws) captured by Hooke in the drawing was fascinating – and spooky! What’s more amazing was that the copy we were looking at was the first edition, now more than 350 years old.

From my conversation with Guthrie, I learned that the Rubenstein Library boasts an expansive portfolio, ranging from the History of Medicine Collections to the Hartman Center for Advertising and Marketing History and the John Hope Franklin Research Center for African and African American History and Culture. While the library is interested in the areas correlated to its existing centers, the acquisition of materials is also heavily guided by student and faculty interests, which is evident in the diversity of Rubenstein collections. For instance, did you know that you could spend an afternoon with historically significant comic books? If that’s not your thing, you could opt to bring a few friends and spend some time playing ancient board games instead.

During my visit, I also spoke to Andy Armacost, Head of Collection Development at the Rubenstein. He introduced me to my favorite artifacts at the event, both hailing from the Hartman Center’s Consumer Reports Collection. The first was an apparatus testing the quality of razor blades: the wood frame was covered with meandering strings and fixtures, with the experimental blade placed adjacent to the test material, positioned in the center of the entire object. The second was a newer device, the structure composed of metal and testing toothpaste, which was applied by a toothbrush onto a grimy dental fixture. Both Armacost and I chuckled at the thought of making the fake teeth “dirty” before each trial… it must have been a sight for the experimenters!

Can you spot the remaining residue on the artificial teeth? Crest needs to do better according to this test machine!

Duke community members continued to stream in to event. Right as I was about to visit the “make a button” station, I spotted Pratt Dean Jerome Lynch in the room as well, testing out visual perception glasses that turned 2D images into 3D scenes. As a Biomedical Engineering student, I could not help walking over to him and asking a few questions regarding his perspective on the exhibition. Lynch was extremely welcoming to my questions and offered many words of advice to Pratt students regarding utilizing the libraries’ rich resources. He encouraged engineering students to frequent the Rubenstein collections, arguing that the artifacts illuminate the evolution of the role of engineers and how previous engineers creatively addressed the great contemporary challenges. He also expressed his personal interest in history… thus defeating any claims that engineers could not simultaneously enjoy the humanities.

The perception goggles that both Dean Lynch and I peeked into during the Engineering Extravaganza!

Before leaving, I made sure to speak to Ingold again, given that she was a leading organizer of the event. Well, she maintains that it was a group effort, so perhaps I should edit “leading organizer” into “co-organizer.” Anyhow, she expressed strong enthusiasm for student involvement in the Rubenstein collections, calling for those interested in exhibit curation to reach out and seek opportunities to do so. She also touted an upcoming Spring exhibition and the likely return of the extravaganza next Fall… Keep vigilant on more information for these events!

Next time you enter through Rubenstein doors, take a moment to check out the storied collections. I promise you will not be disappointed!

By Stone Yan, Class of 2028

A Grueling Math Test So Hard, Almost No One Gets a Perfect Score

Yet hundreds of schools compete each year, and this time the Blue Devils made it into the top three

Duke places 3 out of 471 in North America’s most prestigious math competition. The top-scoring 2023 Putnam team consisted of (from L to R): Erick Jiang ’26, Kai Wang ’27, and Fletch Rydell ’26.
Duke placed third out of 471 schools in North America’s most prestigious math competition, the Putnam. The top-scoring team consisted of (L to R): Erick Jiang ’26, Kai Wang ’27, and Fletch Rydell ’26.

Every year, thousands of college students from across the U.S. and Canada give up a full Saturday before finals begin to take a notoriously difficult, 6-hour math test — and not for a grade, but for fun.

In “the Putnam,” as it’s known, contestants spend two 3-hour sessions trying to solve 12 proof-based math problems worth 10 points apiece.

More than 150,000 people have taken the exam in the contest’s 85-year history, but only five times has someone earned a perfect score. Total scores of 1 or 0 are not uncommon.

Despite the odds, the Blue Devils had a strong showing this year.

A total of 3,857 students from 471 schools competed in the December contest. In results announced Feb. 16, a Duke team consisting of Erick Jiang ’26, James “Fletch” Rydell ’26 and Kaixin “Kai” Wang ’27 ranked third in North America behind MIT and Harvard, winning a $15,000 prize for Duke and each taking home $600 for themselves.

According to mathematics professor Lenny Ng, it’s Duke’s best performance in almost 20 years.

“This is the first time a Duke team has placed this high since 2005,” said Ng, who was a three-time Putnam Fellow himself, finishing in the top five each year he was an undergraduate at Harvard.

Duke students sit for an all-day math marathon.

There’s no official syllabus for prepping for the Putnam. To get ready, the students practice working through problems and discussing their solutions in a weekly problem-solving seminar held each fall.

Students serve as the instructors, focusing on a different topic each week ranging from calculus to number theory.

“They get a sense of what the problems are like, so it’s not quite as intimidating as it might be if they went into the contest cold,” said math department chair Robert Bryant.

“Not only do they learn how to do the problems, but they also get to know each other,” said professor emeritus David Kraines, who has coached Duke Putnam participants for more than 30 years.

Kraines said 8-10 students take his problem-solving seminar for credit each fall. “We always get another 10 or so who come for the pizza,” Kraines said.

The biggest difference between a Putnam problem and a homework problem, said engineering student Rydell, is that usually with a homework problem you’ve already been shown what to do; you just have to apply it.

Whereas most of the time in math competitions like the Putnam, “there’s no clear path forward when you first see the problem,” Rydell said. “They’re more about finding some insight or way of looking at the problem in a different perspective.”

Putnam problems are meant to be solvable using only paper and pencil — no computing power required. The contestants work through each problem by hand, trying different paths towards a solution and spelling out their reasoning step-by-step.

This year, one problem involved determining how many configurations of coins are possible given a grid with coins sitting in some of the squares, if those coins are only allowed to move in certain ways.

Another question required knowing something about the geometry of a 20-sided shape known as a icosahedron.

“That was the one I struggled with the most,” said Wang, whose individual score nevertheless tied him for sixth place overall out of 3,857 contestants.

A sample of problems from the 84th Putnam Competition.

The most common question he gets asked about the Putnam, Rydell said, is not so much what’s on the test, but why people take it in the first place.

This year’s test was so challenging that a score of 78 out of 120 or better — just 65% — was enough to earn a spot in the top 10.

Most of the people who took it scored less than 10%, which means many problems went unsolved.

“For days after I took the Putnam, I would think about the problems and wonder: could I have done it better this way? You can become obsessed,” said Bryant, who took the Putnam in the 1970s as a college student at NC State.

Sophomores Jiang and Rydell, who both ranked in the top 5%, see it as an opportunity to “meet people who also enjoy problem solving,” Jiang said.

“I’m not a math major so I probably wouldn’t do much of this kind of problem solving otherwise,” Rydell said.

For Rydell it’s also the aha moment: “Just the reward of when you solve a problem, the feeling of making that breakthrough,” Rydell said.

Professor Kraines’ weekly problem-solving seminar, MATH 283S, takes place on Tuesday evenings at 6:15 p.m. during the fall semester. Registration for Fall 2024 begins April 3.

Robin Smith
By Robin Smith, Marketing & Communications

Sharing a Love of Electrical Engineering With Her Students

Note: Each year, we partner with Dr. Amy Sheck’s students at the North Carolina School of Science and Math to profile some unsung heroes of the Duke research community. This is the seventh of eight posts.

“As a young girl, I always knew I wanted to be a scientist,” Dr. Tania Roy shares as she sits in her Duke Engineering office located next to state-of-the-art research equipment.

Dr. Tania Roy of Duke Engineering

The path to achieving her dream took her to many places and unique research opportunities. After completing her bachelor’s in India, she found herself pursuing further studies at universities in the United States, eventually receiving her Ph.D. from Vanderbilt University. 

Throughout these years Roy was able to explore and contribute to a variety of fields within electrical engineering, including energy-efficient electronics, two-dimensional materials, and neuromorphic computing, among others. But her deepest passion and commitment is to engage upcoming generations with electrical engineering research. 

As an assistant professor of electrical and computer engineering within Duke’s Pratt School of Engineering, Tania Roy gets to do exactly that. She finds happiness in mentoring her passionate young students. They work on projects focused on various problems in fields such as Biomedical Engineering (BME) and Mechanical Engineering, but her special focus is Electrical Engineering. 

Roy walks through the facilities carefully explaining the purpose of each piece of equipment when we run into one of her students. She explains how his project involves developing hardware for artificial intelligence, and the core idea of computer vision. 

Roy in her previous lab at the University of Central Florida. (UCF photo)

Through sharing her passion for electrical engineering, Roy hopes to motivate and inspire a new generation. 

“The field of electrical engineering is expected to experience immense growth in the future, especially with the recent trends in technological development,” she says, explaining that there needs to be more interest in the field of electrical engineering for the growth to meet demand. 

The recent shortage of semiconductor chips for the industrial market is an example of this. It poses a crucial problem to the supply and demand of various products that rely on these fundamental components, Roy says. By increasing the interest of students, and therefore increasing the number of students pursuing electrical engineering, we can build a foundation for the advancement of technologies powering our society today, says Roy.

Coming with a strong background of research herself, she is well equipped for the role of advocate and mentor. She has worked with gallium nitride for high voltage breakdowns. This is when the insulation between two conductors or electrical components fails, allowing electrical current to flow through the insulation. This breakdown usually occurs when the voltage across the insulating material exceeds a certain threshold known as the breakdown voltage.

In electric vehicles, high breakdown voltage is crucial for several reasons related to the safety, performance, and efficiency of the vehicle’s electrical system, and Roy’s work directly impacts this. She has also conducted extensive research on 2D materials and their photovoltaic capabilities, and is currently working on developing brain-inspired computer architectures for machine learning algorithms. Similar to the work of her student, this research utilizes the structure of the human brain to model an architecture for AI, replicating the synapses and neural connections.

As passionate as she is about research, she shares that she used to love to go to art galleries and look at paintings, “I could do it for hours,” Roy says. Currently, if she is not actively pursuing her research, she enjoys spending time with her two young children. 

“I hope to share my dream with this new generation,” Roy concludes.

Guest post by Sutharsika Kumar, North Carolina School of Science and Mathematics, Class of 2024

Inventors, Assemble: The Newest Gadgets Coming Out of Duke

What do a smart toilet, an analog film app, and metamaterial computer chips have in common? They were all invented at Duke!

The Office for Translation & Commercialization—which supports Duke innovators bringing new technologies to market—recently hosted its fifth annual Invented at Duke celebration. With nine featured inventors and 300 attendees, it was an energetic atmosphere to network and learn.

Attendees mingle in Penn Pavilion. Credit: Brian Mullins Photography.

When event organizer Fedor Kossakovski was selecting booths, the name of the game was diversity—from medicine to art, from graduate students to faculty. “Hopefully people feel like they see themselves in these [inventors] and it’s representative of Duke overall,” he said. Indeed, as I munched through my second Oreo bar from the snack table and made the rounds, this diversity became apparent. Here are just two of the inventions on display:

Guided Medical Solutions

The first thing you’ll notice at Jacob Peloquin’s booth is a massive rubber torso.

As he replaces a punctured layer of rubber skin with a shiny new one, Peloquin beckons us over to watch. Using his OptiSETT device, he demonstrates easy insertion and placement of a chest tube.

“Currently, the method that’s used is you make an incision, and then place your fingers through, and then take the tube and place that between your fingers,” Peloquin explained. This results in a dangerously large incision that cuts through fascia and muscle; in fact, one-third of these procedures currently end in complications.

Peloquin’s device is a trocar—a thin plastic cylinder with a pointed tip at one end and tubing coming out of the other. It includes a pressure-based feedback system that tells you exactly how deep to cut, avoiding damage to the lungs or liver, and a camera to aid placement. Once the device is inserted, the outer piece can be removed so only the tubing remains.

Peloquin demonstrates his OptiSETT device. Credit: Brian Mullins Photography.

Peloquin—a mechanical engineering graduate student—was originally approached by the surgeons behind OptiSETT to assist with 3D printing. “They needed help, so I kind of helped those initial prototypes, then we realized there might be a market for this,” he said. Now, as he finishes his doctorate, he has a plethora of opportunities to continue working on OptiSETT full-time—starting a company, partnering with the Department of Defense, and integrating machine learning to interpret the camera feed.

It’s amazing how much can change in a couple years, and how much good a rubber torso can do.

GRIP Display

This invention is for my fellow molecular biology enthusiasts—for the lovers of cells, genes, and proteins!

The theme of Victoria Goldenshtein’s booth is things that stick together. It features an adorable claw machine that grabs onto its stuffed animal targets, and a lime green plastic molecule that can grab DNA. Although the molecule looks complex, Goldenshtein says its function is straightforward. “This just serves as a glue between protein and the DNA [that encodes it].”

Goldenshtein—a postdoctoral associate in biomedical engineering—uses her lime green molecular model to demonstrate GRIP’s function. Credit: Brian Mullins Photography.

Goldenshtein applies this technology to an especially relevant class of proteins—antibodies. Antibodies are produced by the immune system to bind and neutralize foreign substances like disease. They can be leveraged to create drug therapies, but first we need to know which gene corresponds to which antibody and which disease. That’s where GRIP steps in.

“You would display an antibody and you would vary the antibody—a billion different variations—and attach each one to the system. This grabs the DNA,” Goldenshtein said.

Then, you mix these billions of antibody-DNA pairs with disease cells to see which one attaches. Once you’ve found the right one, the DNA is readily available to be amplified, making an army of the same disease-battling antibody. Goldenshtein says this method of high-throughput screening can be used to find a cancer cure.

Although GRIP be but small, its applications are mighty.

Explore Other Booths

  • Coprata: a smart toilet that tracks your digestive health
  • inSoma Bio: a polymer that aids soft-tissue reconstruction
  • Spoolyard: a platform for exploring digital footage with analog film techniques
  • FaunaLabs: smart watches for our furry friends
  • G1 Optics: a tonometer to automatically detect eye pressure
  • TheraSplice: precision RNA splicing to treat cancer
  • Neurophos: metamaterial photonics for powering ultra-fast AI computation

As I finished my last Oreo bar and prepared for the trek back to East Campus, I was presented with a parting gift—a leather notebook with “Inventor” embossed on the cover. “No pressure,” said the employee who was handing them out with a wink.

I thought about the unique and diverse people I’d met that night—an undergraduate working in the Co-Lab, an ECE graduate student, and even a librarian from UNC—and smiled. As long as we each keep imagining and scribbling in our notebooks, there’s no doubt we can invent something that changes the world.

Post by Michelle Li, Class of 2027

How to be a Global Inventor

Gadgets, devices, doo-dads, oh my! The Duke Global Health Institute (DGHI)  recently hosted three of its members to lead a panel on creating medical devices for low- and middle-income countries. The event was called “Global Medical Device Innovation: Three Models for Creation and Commercialization.”

Each sought to decrease costs and increase scalability for medical procedures. In short, they are expert inventors who are doing good in the world. 

Two of the most prominent inventors of our era. Image courtesy of Disney.

We’ll go step-by-step in a moment, but to start you on your journey to being just like our panelists, here’s a short glossary:

Standard-of-care: a public health term for the way things are usually done.

IRB: institutional review board, a group of people, usually based in universities, that protect human subjects in research studies. 

Screening: when doctors look at signs your body might show to determine
whether you need to be tested for certain conditions. 

Supply-chain: the movement of materials your product goes through before, during, and after manufacturing. It is a general term for a group of different suppliers, factories, vendors, advertisers, researchers, and others that work separately. 

Regulatory pathways: supply-chain for government approvals and other paperwork you need to have before introducing your product to the public.

Step 1: Meet your Mentors

Walter Lee is Chief of Staff of the Department of Head and Neck Surgery & Communication Sciences, Co-Director of the Head and Neck Program, and an affiliate faculty member at the Duke Global Health Institute. He presented ENlyT (pronounced like en-light), a newfangled nasopharyngoscope – a camera that goes down your nose and down your throat to screen for cancer. He wants to expand with partners in Vietnam and Singapore. 

Marlee Kreiger helped found the Center for Global Women’s Health Technologies at Duke in 2007. Since then, she has led the Center in many interdisciplinary and international ventures. In fact, the Center for Global Women’s Health Technologies spans both the Pratt School of Engineering and the Trinity College of Arts and Sciences. She presented on the Callascope, a pocket-sized colposcope – a camera device for cervical cancer screening. 

Julias Mugaga will soon be a visiting scholar at Duke – until then, he heads Design Cube at Makerere University in Uganda. He presented his KeyScope, a plug-and-play surgical camera with 0.3% of the cost of standard-of-care cameras. 

Kreiger’s presentation slides

Step 2: Name your Audience

DGHI has “global” in the name, so it is no surprise that these presenters serve communities around the world. Perhaps something that inventors like Dr. Doofenshmirtz often get wrong is that new innovation should come at the benefit of underserved communities, not at the cost of them. For Lee, that focus would be in his collaborations in Vietnam; for Mugaga it was his community in Uganda; and for Kreiger, it was the many studies conducted in Zambia, Tanzania, Kenya, Costa Rica, Honduras, and India.

Each of the presenters could agree that the main strategy is simple: find partners. Community members on the ground. Organizations that can benefit from your presence.

Another prominent–albeit villainous–inventor, Dr. Doofenshmirtz. Image courtesy of Disney.

Another notable aspect of your audience will be the certification you vie for. Depending on your location, you may need different permissions to distribute your product, or even begin on the journey to secure funding from certain sources.

In the United States, the most relevant regulatory pathway is FDA clearance, which is notably less restrictive than the CE mark distributed in the European Union. Both certifications are accepted in other countries, but many of the inventors on the panel opted to secure a CE mark to potentially appeal to a wider variety of governments around the world.

ISO is an international organization that is also necessary for certification, particularly if you are looking to test a medical product. No reason to be dragged down by the paperwork, though! When asked about securing Ugandan product certification, Mugaga declared, “This is one of the most exciting journeys I have taken.” His path to clearance was even more wrought with uncertainty – without steady sources of material in the Ugandan economy, it is harder to earn FDA or CE approval, two of the most widely-acknowledged certifications in the world. 

Mugaga’s presentation slides

Step 3: Test 

Now that you have permission, you can start changing lives. Many participants in our panelists’ studies were patients in community health clinics across the globe. Their partners in these clinics also had the opportunity to save tens to hundreds of thousands of dollars in equipment. While it seems like a no-brainer, there are ethical concerns that need to be addressed first. For that, you need to fill out…. You guessed it: more paperwork. IRB approval is usually granted by educational institutions (as you should recall from my handy glossary), and is crucial to secure before any testing with humans is started. In fact, the government (and most private investors) won’t even give you a second glance if you ask them for money without IRB approval. 

One big hurdle many of the panelists noted was a distrust of the technology and institution it came from – a foreign entity testing their products on you does not always invoke fear, but it certainly does not always promote trust. Kreiger noted that the work of their community health partners does the heavy lifting on that front; not only are they known community pillars, but they have authority to promote health technology through their existing relationships. If you run into trouble identifying partners in your inventorship journey–never fear. Lee has a message for you: “Ask around. At Duke, there’s always an expert around who’s willing to lend you their time.”

Step 4: Distribute

Now that you are an expert, your invention works, and you’re saving lives, you can attempt to cement your design as standard-of-care. This may look different depending on where in the world you want to distribute, but the next step is to contract a large-scale manufacturer. Your materials have been sourced by now (FDA says they better be) — so finding someone to put them together at an industrial scale should be easy! Your cost may fluctuate at this scale with the increased labor costs, but bulk production and distribution altogether should provide you, your institution, and your clients the best possible chance at changing the world. 

Lee did not receive NIH funding until his fourth attempt at applying. Kreiger did not settle on the first manufacturer contracted. Mugaga is still in the process of securing a CE mark. And yet, all of them are success stories. You can see the ENlyT saving lives in hospitals in Vietnam; you can track the reallocation of $18,000 in savings from purchasing a Calloscope; and if you’re lucky, you’ll catch Mulgaga on campus next year as a visiting scholar at Duke!

Post by Olivia Ares, Class of 2025

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