Following the people and events that make up the research community at Duke

Students exploring the Innovation Co-Lab

Author: Karl Bates Page 12 of 18

Director of Research Communications, Duke University

Medical Historian Finds Dr. Harris

Guest Post by Leah Montgomery, NC Central University

Medical historian Margaret Humphreys discovered Dr. Joseph Dennis Harris in a handwritten report from the Civil War. She was looking through the United States Sanitary Commission papers during her year at the “clubhouse” — the National Humanities Center (NHC) in Research Triangle, NC.

“When I began my research, he was an unknown figure in the history of Civil War medicine,” Humphreys said. “The fact that I was able to reconstruct his life history beginning with this enigmatic reference is a tribute to the modern tools of digitization, search engines and librarians especially, in the rediscovery of minority figures. Ancestry.com proved especially helpful.”

The historical display, "Binding Wounds, Pushing Boundaries," appears at the Medical Center Library through July 19.

The historical display, “Binding Wounds, Pushing Boundaries,” appears at the Medical Center Library through July 19.

Humphreys, the Josiah Charles Trent Professor of the History of Medicine and Professor of Medicine at Duke University, recently shared the story of this pioneering African-American physician in a Medical Center Library lecture as part of “Binding Wounds, Pushing Boundaries: African Americans in Civil War Medicine” an exhibition on display in the medical library through July 19.

Harris was born in North Carolina to free-colored father Jacob Harris, and mulatto mother Charlotte Dismukes Harris in 1833. At age 17, Harris and his mother migrated to Cleveland, Ohio from Fayetteville, NC.

After farming and working as a blacksmith as a young adult, Harris later studied chemistry and surgery at the Medical Department of the Western Reserve College.

From Cleveland, Harris went on to get an MD diploma from a medical college in Keokuk, Iowa.

Margaret Humphreys MD is also a PhD historian.

Margaret Humphreys MD is also a PhD historian.

During the Civil War, Harris was an acting assistant surgeon at Balfour Hospital in Portsmouth, VA, where he oversaw a ward of about 100 black patients, Union troops and freemen. He was later assigned to two more wards of equivalent size.

In 1865, Harris sought a commission as a Union surgeon but failed to do so due to lack of opportunity. He instead became a physician in Freedmen’s bureau hospitals in Virginia.

Humphreys’ eyes lit up as she quickly read through the papers.

In the spring of 1869, Harris was nominated for lieutenant governor of Virginia, attaining 99,600 votes. It was not enough to win however; he also failed in a bid for a US Senate seat when he received just two of the 32 state legislature votes.

Humphreys said Harris’ genuine character, relentless determination and intellectual capabilities helped to set the standard for African-American medicine.

“Harris is a person whose action in the 1850’s mattered, his actions in reconstruction mattered; (his work) is a continuum, the lives were a continuum,” said Humphreys.

Humphreys is the President of the American Association for the History of Medicine and the author of “Marrow of Tragedy: The Health Crisis of the American Civil War” (Johns Hopkins University Press, 2013), which examines the history of medicine during the American Civil War.

The six-banner traveling exhibition now on display in the library was developed by the Exhibition Program at the National Library of Medicine. It features African-American men and women who served as surgeons and nurses during the American Civil War and the impact of their service on the existing ideas of race and gender, expanding the limitations of the role of African Americans in America.

Dr. Humphreys’ presentation was co-sponsored by the Duke University Medical Center Library & Archives and the History of Medicine Collections in the David M. Rubenstein Rare Book & Manuscript Library.

Interfaith Groups Build Bridges Praying Together

By Eric Ferreri, News & Communications

Organizations are turning to prayer to help bridge differences among employees, according to a new study involving a Duke University graduate student.

The study finds that interfaith group prayer serves as a “bridging cultural practice” within multi-faith groups studied by three researchers including Brad Fulton, a PhD student in Duke’s sociology department.

Interfaith prayer builds bridges if diversity is acknowledged and accepted. (iStock photo)

Interfaith prayer builds bridges if diversity is acknowledged and accepted. (iStock photo)

The study, published this month in the American Sociological Review, consists of data from a national study of multi-faith community organizing groups.

Interfaith group prayers took place in about 75 percent of the diverse gatherings analyzed over two years. Those prayers are considered a “bridging cultural practice,”  a way to help people of disparate backgrounds find common ground.

Fulton acknowledged that prayer doesn’t work for all groups or organizations. But bridging practices aren’t just religious in nature. Some could involve food, sports or other activities. And he believes organizations that focus on the similarities of their people but ignore differences aren’t realizing the full benefits of diversity.

“It is risky to simply assume that people from diverse backgrounds will automatically work well together,” he said. “More diversity tends to correspond with more challenges. But organizations tend to be more effective when they engage, rather than avoid, the varied backgrounds represented in their workforce.”

Fulton is one of three co-authors of the paper along with Ruth Braunstein of the University of Connecticut and Richard L. Wood from the University of New Mexico.

Primary funding for the national study was provided by Interfaith Funders, along with secondary grants from the Hearst Foundation, Society for the Scientific Study of Religion, Religious Research Association, the Louisville Institute, and Duke University.

 

 

 

Duke Researchers Cited for Their Influence

 

We are the champions, my friend.

We are the champions, my friend.

By Karl Leif Bates

A new compilation of the world’s most-cited scientists just released by Thomson Reuters (our friends from March Madness), shows that 32 Duke researchers are in the top one percent of their fields.

There are 3215 most-cited scientists on the list, so perhaps that makes Duke the one percent of the one percent?

Most-cited means a particular paper has been named frequently in the references by other papers in that field.

And that “is a measure of gross influence that often correlates well with community perceptions of research leaders within a field,” Thomson Reuters says. The database company admits their study methodology does favor senior authors who have had their papers out there longer, but there are quite a few younger Duke researchers in this list too.

From the Medical Center, the tops in citations in clinical medicine are cardiologists  Eric Peterson, Robert Califf, Christopher Granger, and Eric Magnus Ohman. Michael Pencina, a biostatistician at the Duke Clinical Research Institute, is also most-cited in clinical medicine.

Perhaps not surprisingly, Nobel laureate, biochemist, and father of the G-protein coupled receptor Robert Lefkowitz made the list in pharmacology and toxicology.

Barton Haynes and David Montefiori of the Duke Human Vaccine Institute are listed in the microbiology category.

Medical School basic scientist Bryan Cullen of Molecular Genetics and Microbiology was cited in microbiology.

In psychiatry/psychology, A. John Rush, the vice dean for clinical research at Duke-NUS School of Medicine in Singapore, made the list, as did Richard Keefe, Joseph McEvoy of psychiatry and Avshalom Caspi, and Terrie Moffitt of Psychology & Neuroscience in Arts & Sciences.

Also from Trinity College of Arts and Sciences, Ahmad Hariri and HonaLee Harrington of Psychology & Neuroscience also made the list in psychiatry/psychology. Benjamin Wiley was oft-cited in Chemistry, James Berger and Ingrid Daubechies in mathematics, and plant biologists Philip Benfey, Xinnian Dong and Tai-Ping Sun in the category of plant and animal science.

Sanford School of Public Policy Dean Kelly Brownell is on the list in general social sciences, along with Arts & Sciences sociologist James Moody and nutrition researcher Mary Story of community and family medicine and the Duke Global Health Institute.

Nicholas School of the Environment researchers Robert Jackson and Heather Stapleton were cited the environment/ecology category.

From the Pratt School of Engineering, David R. Smith was cited in the physics category and Jennifer West in materials science.

The economics and business category includes Dan Ariely along with his Fuqua School of Business colleagues Campbell Harvey and Arts & Sciences economist Tim Bollerslev.

The Thomson Reuters analysis is based on their Web of Science database. This is the first time it has been done since 2001, when there were 45 Duke names on the list (including five that appeared again this time), but the methodology has changed somewhat.

UPDATE – There’s now a full PDF report  from Thomson Reuters for download – http://sciencewatch.com/sites/sw/files/sw-article/media/worlds-most-influential-scientific-minds-2014.pdf

 

Neutrinoless Search Still Neutrinoless, For Now

By Karl Leif Bates

Phil Barbeau is an assistant professor of physics in the Triangle Universities Nuclear Lab.

Phil Barbeau is an assistant professor of physics in the Triangle Universities Nuclear Lab.

An international team of neutrino hunters, including Duke physicist Phil Barbeau, is publishing an update this week on the first two years of an ambitious experiment called EXO-200. (The cool name stands for 200-kilogram Enriched Xenon Observatory.)

What the team is after is “neutrinoless double-beta decay,” a particular reaction that’s expected once in 10 to the 25 years in a given molecule of xenon. At about a billion times longer than the age of the universe, that’s a little long to make the funding agencies wait for results, “so we use Avogadro’s number to fight that,” said Barbeau, who is an assistant professor of physics and member of the Triangle Universities Nuclear Lab.

EXO-200

The vessel at the heart of EXO-200 holds pure Xenon 136 and was built in a class 100 clean room.

EXO-200 is a 40-centimeter cylinder of very thin, almost balloon-like copper containing 200 kg of pure Xenon 136. That capsule is in turn surrounded by a vacuum, another thin copper shell, a foot-thick layer of lead, chilled to -100C and buried 2,150 feet underground in a New Mexico salt dome. They really don’t want any intrinsic radiation confusing things.

Unfortunately, the scientific team has been locked out of their underground lair for months by safety concerns following a radiation leak at the federal facility, so the experiment is on hold until things get cleaned up.

EXO-200 is so sensitive that even the super-tiny amount of radiation contained in a human fingerprint would throw it off, so all of this has to be super-cleanroom-clean too.

If the device can see a neutrinoless double-beta decay, it would strongly suggest the existence of a theoretical Dirac neutrino of unknown mass, AND that this particle exists simultaneously as a particle and its own anti-particle. And that, in turn, would poke another hole in the Standard Model of physics.

A gorgeous hand-built array of "avalanche photodiodes" captures faint ultraviolet flashes of particle decay.

A gorgeous hand-built array of “avalanche photodiodes” captures faint ultraviolet flashes of particle decay.

If this is all starting to sound a little crazy, just know that these little fellas are candidates for both dark matter and dark energy, the huge missing variable in the mass and energy of the entire universe. So finding them would be helpful. (Here’s a really good article (PDF) in Physics World by Stanford physicists.)

Xenon 136 isotopes occur naturally at about 20 percent of a population of xenon, so the scientists sent a $3 million ton of xenon to Russia to be spun in the sorts of industrial centrifuges that were formerly used to purify fission materials for nuclear bombs. Swords become plowshares, the Russians keep the lighter Xenon and re-sell it, and the scientists get their enriched 136 for the experiment.

EXO-200 is one of several competing experimental designs that are being used as a proof of concept for the Department of Energy. As physicists are wont to do, they’re drawing up plans to build a detector that is five to 25 times bigger, but first these teams have to figure out which approach works best.

Barbeau said this week’s update on EXO-200 is essentially that they haven’t seen anything so far, other than establishing that the detector is working really well and probably capable of catching the neutrinoless double-beta when it happens. “One thing that’s a constant with the neutrino is that it’s always surprising us,” Barbeau said.

The update appears as an advance online paper in Nature June 4.

EXO-200’s international team of physicists  is supported by the Department of Energy and National Science Foundation in the United States, the NSERC in Canada, SNF in Switzerland, NRF in Korea, RFBR in Russia and DFG Cluster of Excellence “Universe” in Germany.

Hey, Tone it Down Little Man

By Karl Leif Bates

If your preferred method of attracting a mate is to bob your head vigorously and flash your chin-fan, you’d better tone it down a notch when there are predators around, lest you become lunch and not Dad.

The fan-waving, head-bobbing social display of a frisky male Anole sagrei tends to be more subtle and subdued …

The fan-waving, head-bobbing social display of a frisky male Anole sagrei tends to be more subtle and subdued …

That’s the take-away advice generated by biology assistant professor Manuel Leal and graduate student David Steinberg in a new paper appearing the week of May 19 in the Proceedings of the National Academy of Sciences. (Visit their lab.)

On nine tiny islands in the Snake Creek region of Great Abaco Island in the Bahamas, the biologists videotaped and observed the social mating behavior of head-bobbing, fan-waving  Anole sagrei studs. Five of the islands also harbored the anoles’ predator, the curly-tailed lizard Leiocephalus carinatus, who is a bit bigger and mostly stays on the ground.

When the predators were present, the anoles chose to do their displays twice as high off the ground and they reduced the amplitude of their head bobs by as much as 60 percent.

...when his major predator, the curly-tailed lizard Leiocephalus carinatus is at large. (credits: Manuel Leal)

…when his major predator, the curly-tailed lizard Leiocephalus carinatus is at large. (credits: Manuel Leal)

The anoles spent just as much time displaying when the predators were around, but doing so a little less flamboyantly may mean the females have to be closer to catch the signal, Leal said. And that, in turn, may affect mating success and how the anole males set up their territories.

CITATION: “Predation-associated modulation of movement-based signals by a Bahamian lizard,” David S. Steinberg, Jonathan B. Losos, Thomas W. Schoener, David A. Spiller, Jason J. Kolbe and Manuel Leal. Proceedings of the National Academy of Sciences, week of May 19, 2014. DOI: 10.1073/pnas.1407190111

Women in Statistics Starts Here

By Karl Leif Bates

Duke statisticians formed a key variable in launching the first-ever “Women in Statistics” conference that kicks off Thursday, May 15 in Cary.

Duke statistician Dalene Stangl helped launch the first-ever Women in Statistics conference.

Duke statistician Dalene Stangl helped launch the first-ever Women in Statistics conference.

The meeting has attracted more than 300 attendees from around the country, including women from both academics and industry, said co-chair Dalene Stangl, a professor of the practice and associate chair and director of undergraduate studies in Duke’s department of statistics.

Rather than hearing the latest on Beyesian analysis, the group is going to focus on networking, mentoring, career advice and leadership, Stangl said.

The meeting was inspired by a conference called Women in Computer Science that has grown to more than 4,000 attendees. “We’re trying to replicate that,” said Stangl, who is chair of the American Statistical Association’s committee on women.

The inclusion of industry speakers from pharmaceuticals, retail,  and government agencies as well as academics is deliberate Stangl said. “Many of the professional societies are organized around that academic role, but industry is a great option for many women.”

In addition to Stangl, Duke speakers will include Mine Cetinkaya-Rundel and Merlise Clyde (who built the conference web site).

Attendees seem to be a healthy mix of novice and experienced, she added. “If we’re missing a group, it’s probably in the middle, ” she said.  The conference runs through Saturday.

UPDATE – Read Harvard post-doc Stephanie Hicks’ posts from the conference. May 20 and May 14

Lawrence David Gets to the Gut of the Matter

microbiome_streamplot-1024x453

This “stream plot” is a running tally of various microbial populations in the gut over time.

By Karl Leif Bates

Assistant Professor Lawrence David of molecular genetics and microbiology in the Medical School, recently did a star turn on the Radio In Vivo program, talking about his work on the human gut’s incredible rainforest of microbial biodiversity and its interactions with infections, the immune system and our diets. There are ten non-you cells in your gut for every cell of you and their genes outnumber yours about 100 to one.

Lawrence David

Lawrence David

“Our guts are probably some of the world’s most densely colonized microbial communities,” David told host Ernie Hood. It’s a paradise really, with a steady supply of nutrients, constant climate, no sunlight “and only one way in and out.”

Listen to the one-hour April 30 podcast here

And then maybe take another 14 minutes to hear Lawrence absolutely kill at a  Story Colliders session in December 2012, telling the outrageous tale of sampling his own poop for a year and making it through airport security with a backpack full of um, specimens. (Warning – includes some pretty unavoidable scatalogical profanity.)

Visibly Thinking about Undergrad Research

By Karl Leif Bates

Undergraduate research is kind of a big deal at Duke.

The grand finale of nearly 200 of this year’s undergrad projects was a giant poster session called “Visible Thinking,” hosted by the Office of Undergraduate Research Support  on April 22.

Happy and relieved students sharing posters at Visible Thinking 2014. (Megan Morr, Duke Photo)

Happy and relieved students sharing posters at Visible Thinking 2014. (Megan Morr, Duke Photo)

This annual showcase just keeps getting bigger, louder and more crowded, which is a great testament to the involvement of undergrads in all areas of Duke’s research enterprise.

The posters and proud students wearing their interview suits filled all the common areas of the first and second levels of the French Family Science Center on Tuesday and spilled into a few out-of-the-way corners as well.

“For many of the students this is the culmination of their four years, in which they’ve made that transition from student to scholar,” said Ron Grunwald, director of the URS office. “They’re no longer simply learning what other people have discovered, they’re discovering things on their own.”

Indeed, Rebecca Leylek wasn’t the least bit discouraged by having to check her experiment every six hours around the clock for days on end to see how the mice’s wounds were healing. The second phase of her project was a protocol she developed and got approval for and it didn’t have the six-hour part. She’s off to grad school at Stanford in immunology.

Ani Saraswathula, who co-chaired the Duke Undergraduate Research Society, apparently missed the deadline for getting his poster into the printed program, but his science on brain tumors was pretty awesome. He’s sticking around after graduation for an MD/PhD at Duke.

The new Bass Connections research teams brought nearly two dozen posters, showing off projects about energy, environmental health, art history, online education, cognitive development,  and decision-making.

And then, there was just an amazing assortment of stinky lemurs and pathogenic yeast and budding investigators talking curious faculty and students through amazing posters like this: Understanding the role of BNP signaling in pak-3 mediated suppression of synaptic bouton defects in spastin null Drosophila.

So, in addition to quizzing the young scientists about their findings, we thought we’d ask a few of them to recite their impressive poster titles from memory:

[youtube http://www.youtube.com/watch?v=HWJWEs427WM?rel=0]

Send in the Nerds

By Karl Leif Bates

Yeah, we're a bit excitable.

Yeah, we’re a bit excitable.

Hoping to triumph where our men’s and women’s basketball teams fell short, the Duke faculty are in the Final Four of an alternative NCAA bracket based on academic publications that’s being run by Thomson Reuters.

Sure, it’s a gimmick to get people looking at Thomson Reuters’ powerful but somewhat pricey InCites citation database  — but we’re winning!

By the reckoning of the “Metrics Mania” bracket, Duke is squaring off in the final with Stanford in a contest of “normalized citation impact” of our scholarly work. (It’s a weighted average of citations per paper that controls for year published and subject area.)

Joining us in the Final Four are Harvard and Wisconsin — kudos to the Badgers for making it both ways! We’ve apparently already beat Wisconsin on the normalized citation business, so now it’s on to the Cardinal.

Previous rounds had us clobbering Mercer (cough) and Iowa on absolute number of citations and then squeaking past Michigan and NC State on percentage of documents cited.

The national champion will be announced Tuesday, after the basketball game, Thomson Reuters’ savvy PR operation says.

*** UPDATE – Tuesday, April 8 ***

Stanford was declared the winner.  We’re done talking about this. 🙁

Metrics Mania – Research Analytics – Thomson Reuters

Messenger of Pain Identified

Pain researcher Ru-Rong Ji is a distinguished professor of anesthesiology and professor of neurobiology.

Pain researcher Ru-Rong Ji is a distinguished professor of anesthesiology and professor of neurobiology.

By Karl Leif Bates

In their pursuit of understanding how pain works at the molecular level, a research team lead by Ru-Rong Ji of anesthesiology and neurobiology has found a new function for MicroRNAs, short stretches of genetic material that signal genes to turn on or off.

In a paper appearing online April 2 in the journal Neuron, Ji and his colleagues in the Pain Signaling and Plasticity Lab describe one MicroRNA called “let-7b” that is found floating outside cells and can bind specifically to pain-sensing neurons.

Let-7b rapidly excites these neurons through the toll-like receptor-7 (TLR7) and its associated ion channel, TRPA1, which leads to a rapid inward flow of ions to the neurons.

Injecting the 22-basepair RNA molecule into the feet of mice induced a sensation of pain within minutes. (The mice are seen lifting the affected paw or licking it.)

The MicroRNA let-7b is the 22 red nucleotides in this diagram. (Image from MiRNAMap site, Institute of Bioinformatics National Chiao Tung University, Hsinchu, Taiwan.)

The MicroRNA let-7b is the 22 red nucleotides in this diagram. (Image from MiRNAMap site, Institute of Bioinformatics National Chiao Tung University, Hsinchu, Taiwan.)

Mutant mice missing the genes for TLR7 and TRPA1 were found to be less susceptible to the signaling molecule or even unaffected by it.

Pain is notoriously difficult to measure, but Ji said the new molecule may serve as a biomarker for pain. “We’re also interested to know if targeting this miRNA would be a way to alleviate pain.”

The study was supported by NIH grants R01-DE17794, R01-DE22743, and NS67686 to Ru-Rong Ji and R21-NS82985 to Zhen-Zhong Xu.

CITATION: “Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1,” Park, Xu, Berta, Han, Chen, Liu and Ji. Neuron, Online April 2, 2014. DOI: 10.1016/j.neuron.2014.02.011

 

Page 12 of 18

Powered by WordPress & Theme by Anders Norén