Research Blog

Following the people and events that make up the research community at Duke

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“Flipping the Bird”: What do Audubon’s Paintings and England’s Crown Jewels Have in Common?

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On the first Friday of each month, Duke Libraries will hold a “Flipping the Bird” event where members of the public can watch exhibit curators flip the pages of two of Audubon’s original “Birds of America” books.

At 12:15 PM on the first Friday of each month, you can watch Duke Libraries curators crank open a half-ton case made by the same company that designed the storage system for England’s Crown Jewels. Inside, protected by elaborate security features and carefully controlled temperature and light conditions, is a different collection of valuable, colorful items: Audubon’s “Birds of America” paintings.

“People love these birds for lots of different reasons,” said Duke Libraries Head of Exhibitions Meg Brown. The Audubon exhibit preserves and displays the birds while also raising awareness of Audubon’s complicated legacy as both a very talented artist and a deeply flawed man.

John James Audubon is one of ornithology’s most well known and most controversial figures. He painted 489 bird species with precision and accuracy, part of an ambitious and unfinished quest to paint every bird in America.

He also owned enslaved people, stole human skulls from indigenous burial sites, and held staunchly racist and anti-abolitionist beliefs.

Even in his own lifetime, Audubon’s “Birds of America” paintings were very valuable. They were sold in “subscriptions” in which patrons would receive paintings periodically as loose sheets and then have them bound themselves. The frequency ranged from weeks to years depending on the speed of Audubon’s work. Today, more than a century and a half after Audubon’s death, his paintings remain subjects of fascination, value, and beauty. One reason the paintings are so valuable is that each set is unique. Audubon used between 20 and 40 colorists who applied color to each print by hand, meaning different copies of the same painting may have slightly different colors.

Approximately 120 complete “Birds of America” sets survive today. “Typically a ‘set’ is all four volumes,” said Aaron Welborn, Duke Libraries Director of Communications. Duke owns “one complete set of four volumes,” two of which are on display in the Mary Duke Biddle Room in Perkins. At the inaugural “Flipping the Bird” event earlier this month, Duke Libraries Head of Exhibitions Meg Brown spoke to visitors about what it takes to preserve and flip these fragile birds.

Head of Exhibitions Meg Brown and Exhibition Intern Grace Zayobi flip the pages of one of the two Audubon books on display in Duke Libraries.

The books are stored in glass and metal cases that weigh more than 1000 pounds according to Brown. The company that made these cases also made the glass under which England’s Crown Jewels are stored. The standard for the glass strength was that it had to be able to withstand 18 minutes of someone actively trying to break through.

The paintings are protected by another unusual security feature as well: “These won’t fit through any of our doors,” Brown said. The cases were brought in during library renovation, and their assembly was completed inside the library.

Duke acquired the collection from Margaret L. Barber, an art and antique collector who loaned items from her private collection for an exhibition in the Women’s College Library in 1931. Duke later purchased the “Birds of America” paintings from her. Originally all four were on display, but for preservation reasons only two are displayed at one time today.

Strips of Mylar—a soft, inert plastic—keep the open pages in place. Curators avoid putting the strips directly on the paintings, instead positioning them closer to the edges of the paper.

Preserving paintings from two centuries ago requires special care. Curators keep sheets of paper between the pages to prevent pigment from transferring to adjacent pages over time. And since watercolor is very sensitive to light exposure, the library uses strategically placed lamps to illuminate the pages without exposing them to bright light. (Specifically, they aim to keep ambient light under 6 foot candles.) UV light is particularly damaging. The exhibit is in an interior room that does not use UV lighting, but there is “one time of day, one time of year” when light streaming through the windows of Saladelia Cafe in Perkins Library can reach the Mary Duke Biddle Room, Brown explains, so the shades on the window facing the cafe are kept below the level that sunlight could reach.

Exhibit curators also monitor temperature and humidity using sensors in the glass cases. The two volumes not on display are kept in the library’s closed stacks, where the temperature is colder to help preserve the paintings. Every couple years the books on display are rotated out with those in the closed stacks.

From left: Yoon Kim, Senior Library Exhibition Technician; Meg Brown, Head of Exhibitions; and Grace Zayobi, Exhibition Intern.

Flipping such old and delicate pages is its own challenge. The display cases have a motorized system to lift the glass, allowing curators to flip the pages before sealing them inside again. The pages of the books on display are flipped once a month. The flipping used to happen when the exhibit was closed, but now any library visitor can witness the process themselves on the first Friday of each month, from 12:15-12:45 PM.

Yoon Kim and Grace Zayobi flipping the book from a page displaying raptors to a page showing the “Bachman’s Finch,” now known as the Bachman’s sparrow.

Though the Audubon exhibit is permanent, other exhibits in the space are temporary. A recent exhibit there has highlighted female scientific illustrators, including Maria Martin Bachman, who painted some of the floral backgrounds for Audubon’s birds. While that exhibit has been up, the library has been focused on “displaying pictures that [Martin] had a part in” rather than just flipping to the next page in order.

Bachman’s husband, Reverend John Bachman, was also a naturalist. He lived in South Carolina and collaborated with Audubon on a later collection of mammal paintings. Like Audubon, Bachman is also a controversial figure with multiple birds named after him. There is a theme here. Also like Audubon, the Bachmans owned enslaved people, some of whom were involved in the production of Audubon’s paintings. A man enslaved by the Bachman family, Thomas Skining, was very skilled at stuffing birds. “He became so good at it that he sort of became the main person who did it,” Brown said.

One of Audubon’s paintings depicts the Carolina parakeet, which he called the Carolina parrot. The species is now extinct.
Image courtesy of the John James Audubon Center at Mill Grove, Montgomery County Audubon Collection, and Zebra Publishing.

Several species in Audubon’s “Birds of America” have since gone extinct: the Carolina parakeet. The Labrador duck. The passenger pigeon. The great auk. In all likelihood the ivory-billed woodpecker and Bachman’s warbler are also extinct. The Eskimo curlew is either critically endangered or extinct as well, and the “pinnated grouse” is an extinct subspecies of the greater prairie-chicken. Many others face threats to their existence, including the Bachman’s sparrow, currently on display in one of the books in the library. (Audubon called it Bachman’s Finch, but the species is not a finch and has since been renamed.)

Light, temperature, and humidity conditions are carefully controlled to help preserve the paintings.

“These are here forever,” Brown said. Audubon’s paintings remain widely loved and influential, and they will remain on display for people to admire, ponder, and learn from. At the same time, the Audubon exhibit seeks to raise awareness of Audubon’s complicated legacy and about the individuals involved in his work who he never fully credited in his lifetime. Context is important, Brown said, and “We never want to shy away from the truth and the history about the important stories that aren’t being told.”

You can view the “Birds of America” books in the Mary Duke Biddle Room, across from the main entrance to Perkins. The species on display this month are the Bachman’s sparrow on the right and mourning, blackburnian, and black-throated green warblers on the left. And at 12:15 on March 7 or the first Friday of any other month, you, too, can watch exhibit curators flip the birds. 

Post by Sophie Cox, Class of 2025

Making the Case for Data Privacy: Here’s What We’re Up Against

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After bringing Data Privacy Day to campus seventeen years ago, Duke faculty Jolynn Dellinger and David Hoffman co-moderated this year’s event at the Law School on January 28. Seated between them were attorneys Joshua Stein and Carol Villegas, partners at law firm Boies Schiller Flexne LPP and Labaton Keller Sucharow, respectively. Both are in the midst of multiple lawsuits against corporate giants; Boies Schiller joined a lawsuit against Meta last year, while Labaton is currently involved in data privacy-related suits against Meta, Flo Health and Amazon, and Google. 

Panelists at Data Privacy Day 2025 at the Duke School of Law

Villegas began by emphasizing the importance of legal action on these issues in light of inadequate legislation. She pointed to the confusion of senators at Mark Zuckerberg’s testimony during the Cambridge Analytica scandal, in which the data of over 50 million Facebook users was misused for political purposes. “They don’t understand it…You can’t expect a legislature like that to make any kind of laws [on data privacy], not to mention technology is just moving way too fast,” Villegas said.  

Facebook and most social media platforms generate revenue through advertisements. While many people are aware that these sites track their activity to better target users with ads, they may not know that these companies can collect data from outside of social apps. So, what does that look like?

Almost all apps are built using Software Development Kits (SDKs), which not only make it easier for developers to create apps but also track analytics. Tracking pixels function similarly for building websites. These kits and pixels are often provided for free by companies like Google and Meta–and it’s not too difficult to guess why this might be an issue. “An SDK is almost like an information highway,” Villegas said. “They’re getting all of the data that you’re putting into an app. So every time you press a button in an app, you know you answer a survey in an app, buy something in an app, all of that information is making its way to Meta and Google to be used in their algorithm.” 

So, there’s more at stake than just your data being tracked on Instagram; tracking pixels are often used by hospitals, raising the concern of sensitive health data being shared with third parties. The popular women’s health app Flo helps users track their fertility and menstrual cycle–information it promised to keep private. Yet in Frasco v. Flo Health, Labaton alleged it broke confidentiality and violated the Confidentiality of Medical Information Act (CMIA), illegally transmitting data via Software Development Kits to companies like Google and Meta. Flo Health ended up settling out of court with the Federal Trade Commission (FTC) without admitting wrongdoing, though Google failed to escape the case, which remains ongoing. 

It’s not only lawyers who are instrumental to this process. In cases like the ones that Stein and Villegas work on, academics and researchers can play key roles as expert witnesses. From psychiatrists to computer scientists, these experts explain the technical aspects and provide scientific basis to the judge and jury. Getting a great expert is costly and a significant challenge in itself–ideally, they’d be well-regarded in their field, have very specialized knowledge, and have some understanding of court proceedings. “There are really important ways your experts will get attacked for their credibility, for their analysis, for their conclusions, and their qualifications even,” said Stein, referring to Daubert challenges, which can result in expert testimony being excluded from trial. 

The task of finding experts becomes even more daunting when going up against companies as colossal and profitable as Meta. “One issue that’s come up in AI cases, is finding an expert in AI that isn’t being paid by one of these large technology companies or have… grants or funding from one of these companies. And I got turned down by a lot of experts because of that issue,” Stein said. 

Ultimately, some users don’t care that much if their data is being shared, making it more difficult to address privacy and hold corporations accountable. The aforementioned cases filed by Labaton are class action lawsuits, meaning that a smaller group represents a much larger group of individuals–for example, all users of a certain app within a given timeframe. Yes, it may seem pointless to push for data privacy when even the best outcomes in these cases only entitle individuals to small sums of money, often no more than $30. However, these cases have an arguably more important consequence: when successful, they force companies to change their behavior, even if only in small changes to their services. 

By Crystal Han, Class of 2028

Making Sure Drugs Work Where They’re Needed in the Brain

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Treating Parkinson’s and other neurological conditions has been challenging due to a lack of tools capable of navigating the complexity of neural circuits. New precision tools like DART.2 help make those therapeutic aspirations a reality, one tethered drug at a time.

The brain is one of our most complex organs, full of neurons that are constantly communicating with one another at places called synapses. Synapses both release molecules called ligands and express cell surface receptors that the ligands bind to, prompting the cells to undergo various processes within. The kinds of ligands and receptors that are important to disease are often released by and found on a variety of cell types. It is crucial, therefore that when we use a drug that targets a certain receptor, we also make sure that they only interact with receptors on the desired cell type.

To achieve this, in 2018 a team led by Duke professor Mike Tadross introduced “Drugs Acutely Restricted to Tethering” or “DART,” a drug delivery system that allows researchers to administer drugs to specific neuronal cell types. In June of this year, the Tadross lab unveiled DART.2. Pairing the cell-type specificity provided by DART.2 with the cellular receptor-specificity already provided by a given drug is essential to treating diseases like Parkinson’s without severe off-target effects, something researchers have been unable to do until tools like DART entered the scene.

Think of it like cutting the water supply to an apartment that has had a pipe burst. You don’t want to cut the water to the entire building, just the flooding apartment, because the other tenants still need water. This newest version of DART increases the ability of researchers to flip the right switches.

With increased cell type specificity optimized for drugs targeting two different receptor types, enabling broader dosing techniques and opening the door for discoveries of unknown roles of well-known receptors, researchers have made DART.2 into an “even more subtle, refined, yet transformative drug delivery system, a marked improvement from more rudimentary options that operate more like sledgehammers,” said Brenda Shields, one of the lead scientists on the DART.2 project.

The HaloTag protein (HTP) helps recruit drugs tethered to the HaloTag ligand (RXDART) to the desired cell types. Courtesy of Erin Fykes.

This is, in part, owing to the use of natural, or endogenous, receptor machinery in its design. Organisms are infected with a virus that prompts only certain cell types to express HaloTag, a protein that sits on the surface of the cells of choice. A HaloTag ligand, or small molecule that binds specifically to the HaloTag surface protein, is tethered to a drug of choice. This allows the tethered drug to be selectively recruited to the cells that have the HaloTag protein, bringing the drug into closer proximity to its intended cellular receptor, discouraging it from binding to unintended receptors, and reducing the amount of drug needed for efficacy.

DART.2 is not changing receptors that are already present, nor is it affecting the signaling cascades activated by engagement with the receptors. Cell-specificity of drug delivery was improved in DART.2 by decreasing the time and drug concentration needed to achieve intended effects – it is 100 times more precise than the previous system, with desired effects achieved in just 15 minutes.

Using the previous version of DART, researchers tried delivering a tethered version of the drug gabazine to GABA receptors (neural receptors associated with inhibitory neurotransmission) on a select group of neurons – gabazine blocks GABA from binding to GABA receptors and subsequently increases neural activity. Unfortunately, DART did not achieve high enough cell-specificity and gabazine bound to enough off-target receptors to trigger epileptic responses in mouse models. DART.2, however, is capable of delivering gabazine without these effects. The original version of DART was only optimized to work with drugs targeting excitatory (AMPA receptors) neurotransmission. The ability of the current version to work with inhibitory (GABA) and excitatory (AMPA) neurotransmission makes this system useful for “bi-directional” modifications, greatly increasing its utility.

Interestingly, while testing the effects of the drug gabazine on GABA receptors in ventral tegmental area dopamine neurons, they found that GABA receptors on these cells actually suppress locomotion, opposite to findings in other studies that more broadly focused on GABA receptors in multiple cell types. This highlights the need for tools like DART.2 that allow us to understand diverse receptor/ligand dynamics on a cell-by-cell basis to gain more nuanced approaches to understanding and treating disease.

To visualize dispersion and binding of tethered drugs to HaloTag proteins versus off-target receptors, Tadross’s team developed a way of seeing where the tethered drugs accumulated by introducing a small percentage of HaloTag ligands bound to a fluorescent reporter rather than a drug into the pool of tethered drugs. This visualization further confirmed a significant increase in cell-type specificity and a decrease in off-target effects of DART.2.

With previous levels of cell specificity, local delivery of the tethered drugs via cannula insertion at the brain region of interest was necessary to ensure drugs made it to the right targets. With increased specificity and a new visualization method for seeing where DART.2 drugs bind, researchers were able to assess whether brain wide dosing would be possible, decreasing deleterious effects of pumping high concentrations of drug into a certain area. Excitingly, they found that broad administration of tethered drugs across large areas of the brain did not significantly increase binding at receptors on cells not expressing the HaloTag protein. Drug delivery in the brain is notoriously difficult, so having the flexibility to administer a drug from an easier delivery point without reducing binding at target sites translates to a greater chance of therapeutic success.  

For those unfamiliar with the process of drug and therapeutic development, the improvements presented in DART.2 represent a realistic look into the measure of scientific progress. Originally used to treat Parkinson’s mouse models, our conception of DART.2’s therapeutic relevance to other conditions is continually expanding. Shields shared that adaptions for conditions such as anxiety and depression may not be far off, just to name a few. DART.2 also makes it possible to use drugs like opioids in new ways. While helpful for pain management, the addictive potential of opioids sometimes renders them more harmful than helpful. Utilizing DART.2, opioids could be administered more specifically to cells that benefit from the drug, potentially reducing interactions with cell types involved in addiction development. Additionally, researchers are beginning to couple DART.2 with other tools on the market that can enhance its therapeutic promise and applicability (and vice versa). Each improvement of DART brings us closer to the reality of treating conditions we once deemed hopeless.

Post by Erin Fykes, Ph.D. student in cell and molecular biology

The Key to Transforming Minds

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Global wars. Ever-advancing artificial intelligence. Uncertain economic and job market prospects. Climate change. Amidst a world filled with change posing deep questions, could humanities provide counsel to our pressing issues and lead us towards more fulfilling, enriching daily experiences? 

Last week, I had the privilege to speak with Divinity School and history professor Polly Ha, director of the Transformative Ideas program and co-lecturer of “The Good Life,” an acclaimed course exploring the intersection of religion, philosophy, and other ethical issues. “The Good Life” encouraged Duke students, hailing from all disciplines and backgrounds, to slow down and incorporate more reflection and intention into their everyday lives.  

Duke professor Polly Ha, faculty in the Divinity School and director of the Transformative Ideas Program

Why is “slowing down” a key principle of “the Good Life”? As Ha pointed out, “it’s more stressful to try to slow down, to rest and reflect, than to take an exam for some students.” This powerful statement prompted me to reflect on my own experiences at Duke. Is it true that, amidst the hurries of daily academics and extracurriculars, merely pausing and thinking has become a difficult task? Perhaps so. If this is true for first-year students like me, how much more severe is this syndrome for upperclassmen undergraduate and graduate students? 

Ha approaches this topic fully empathizing with the busy lifestyle so many of us lead. “As the daughter of immigrant parents, the pace of my life has always been highly accelerated. The challenge of trying to slow down is something I can definitely relate to,” she commented. Ha identified this as a key reason why she required her Fall 2024 cohort to write down their reflections in physical journals so they could more clearly see their own growth throughout the semester. 

Encouraging Civility
A “Good Life” class is in session. Ha prepares to call on a student while Professor Abdullah Antepli of the Sanford School of Public Policy looks on.

The course professors also prepared students to engage in active civic discourse, a key pillar of the Transformative Ideas program. “Many students expressed that during our course, they felt understood and affirmed by their peers, sometimes for the first time,” Ha remarked. While she acknowledges that the class is not comprehensive in covering all thought-provoking, debatable issues of our day, Ha believes that her class prepares students to tackle all types of topics beyond the scope of the class. This is evident in the course’s continual evolvement to respond to our rapidly changing world: this year, she introduced lectures on transhumanism alongside ancient traditions. 

This appealing curriculum is far from the only major project Ha is undertaking. As an active author, scholar, lecturer, and administrator, she currently devotes much time to writing her newest book, “The Future of Freedom,” and researching history and its lessons on freedom and liberty. She is also involved in a multitude of interdisciplinary projects at Duke and beyond linking history and theology to fields as diverse as bioethics and public policy.  

Ha was gracious enough to provide me with a sneak peak of “The Future of Freedom.” In her words, this book is tailored not just to fellow academics but a broader audience, a read suitable for novices like me. Reading the first chapter, I was already transported into a world where grappling with heated topics is appreciated and celebrated. I especially enjoyed Ha’s continued use of rhetorical questions as she elucidated the modern threats against every liberty we cherish. Quotes like “Can we take freedom of conscience, thought, speech, consent, and action for granted?” challenged my perspective on my relationship to the ongoing battles surrounding surveillance capitalism and privacy protection—and whether I, an involved engineering student with aspirations in healthcare, have a role to play in this predicament. Given the captivating read, I am confident that Ha’s inquiry into 1600s England will enlighten many readers and portray the significance of history in our daily endeavors. 

As we chatted about history’s place within a larger interdisciplinary web of research active on Duke’s campus, Ha provided two incredible insights that could not be neglected in this blog. Firstly, she described history as “a spine that connects to many ideas,” contrary to the popular notion that it is solely a window into the past. If history is by nature interdisciplinary, why are renowned historical works still solely focused on primary sources, dates, and battlefield events? According to Ha, Duke’s interdisciplinary research scene is especially strong. “For me, as someone coming from some specialized cultures that did not have the same interdisciplinary superhighways, this has been something I deeply value,” she remarked.   

From teaching “The Good Life” to researching freedom’s past, present, and future, Ha has contributed much to our scholarly community. By bringing the humanities into conversation with twenty-first century challenges, and offering the immersive opportunities provided by Transformative Ideas, her work promises to sow the seeds in students that will sprout into exemplary lives. 

By Stone Yan, Class of 2028

You Don’t Have to Be a Hacker to Make an Impact in This 24-Hour Coding Sprint

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Twenty four hours full of brainstorming, debugging, and caffeine.  

Coders of all skill levels came together from February 8-9 to participate in the Code for Good hackathon, an annual event hosted by student organization HackDuke. Fueled by pizza and energy drinks, teams of up to four vie for the chance to win prizes ranging from LEGO sets to Apple Watches. Most projects fell into one or more of the four tracks: Health, Finance, Sustainability, and Interactive Media.

This year’s event fittingly took place at the Fuqua School of Business, where giant flags line the walls.

Over the laughter of a Saturday night poker competition — one of the scheduled social activities for participants — I spoke to Rishi Rao, the lead organizer for HackDuke’s Technology team. “Historically, HackDuke has mainly been a Duke/UNC event, but this year we have people from all over the country,” said Rao, who attributes this year’s wide reach to advertising on social media. 

There’s a focus on making the event as open as possible to new coders, including students that don’t study computer science. “A lot of people here are beginners who haven’t been to a hackathon before so we try to encourage [finishing a product] by having a beginner track and having mentors… Speakers do workshops to help people gain the skills necessary,” Rao said. Hackers are also supplied with “beginner tech kits,” consisting of short tutorials and starter projects created by the HackDuke team.

It certainly seems plausible for first-timers to do well. Duke freshmen Alexis Fox, Phillip Lin, Eric Wang, and Siven Panda entered the competition together in the Health track, and took 2nd place in the category. Upon hearing that rescheduling appointments required tedious manual work in hospitals, the team decided to create an interface to automate the process–hence the name Linked Automated Rescheduling Interface (LARI), inspired by the surname of ambulance inventor Dominique–Jean Larrey.

The team created a diagram to display their process and division of tasks

In twenty four hours, most groups only have time to develop a proof of concept. Team LARI noted that they had to manage their expectations for the final product, but also that practicing better time management could’ve allowed them to add more desired features. “We have to make a compromise between learning and perfectionism,” said Lin.

“I wanted to learn something here, so I wrote my [code] in a language I’ve never used before,” said Panda, adding that he would switch back into a familiar language if he didn’t finish parts by a self-imposed deadline.

In settings like hackathons, the short time frame and low experience of many competitors has made AI particularly relevant. Given the advancements in AI in just the last year, it’s no surprise that it’s taken on an outsized role; two of this year’s workshops focused on using it as a tool for coding. “It helps the more experienced teams come to a more complete product and it helps these beginners teams complete a product,” Rao said.

A quick recount of an unproductive day results in suggested reading material. It’s taken note that my entry is less positive than those previously typed by others.

Many also chose to integrate generative AI into their product. First-time participants Carlos and Elijah, a freshman and sophomore from MIT respectively, decided to create “filosof.ai”: a digital journal that analyzes entries for philosophy. They explained their product was aimed towards people just starting to think about philosophy, helping them further develop their interest by identifying the branches closest to their existing thoughts.

Like the aforementioned groups, Duke seniors Julia Hornstein, Owen Jennings, and Chinomnso Okechukwu were also first time hackathon participants.

“I thought, why not, I don’t want to graduate without doing it”, said Hornstein, a computer science major.

They entered on the sustainability track, wanting to create something that would be realistically used. Okechukwu recalled being unable to find clothes for Duke events on short notice, while Hornstein also noted the amount of theme-specific clothing she would no longer have use for after senior year. Soon, their idea came to them: Campus Closet would provide a platform for students within universities to buy and sell clothes by theme. Instead of being bought from Amazon three days beforehand, worn twice, and then tossed away, clothing would remain within the community, reducing waste and fast fashion demand.

Though some enter the competition nervous, most come out feeling accomplished and more confident in their abilities. “This was such a good experience for me and I’m so inspired by the fact that we could do this in twenty four hours,” said Hornstein. “Meeting my team, and the team dynamic…I had so much fun with both of them, honestly.” The group plans to continue working on Campus Closet, and said they looked forward to hanging out both inside and outside of the project.

For the organizers, an ideal hackathon means not only generating high participation but seeing a high number of submissions when the 24 hours come to a close. After receiving the most applications and product submissions in the history of the event, it seems fair to call Code for Good 2025 a success.

By Crystal Han, Class of 2028

Determining Who’s White: How Vague Racial Categories Mask Health Vulnerabilities

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Good healthcare decisions depend on good data – whether you’re making federal health policy or treating a single patient.

But the data is often incomplete – particularly when it comes to defining a group that still makes up the majority of the U.S. population — a ‘non-Hispanic White’ person. That’s the primary reference category used in health data.

“Nobody questions who’s white, but they should,” said Jen’nan Read, a Duke sociologist and lead author of new research recently published in the journal Demography. “The white category contains diverse ethnic subgroups, but because we lump them all together, we miss important health vulnerabilities for millions of Americans.”

Read and co-author Fatima Fairfax, a Duke doctoral student in sociology, analyzed data from the 2000 to 2018 waves of the National Health Interview Survey to compare the health of white adults born in the U.S., Europe, the Middle East, and the Former Soviet Union.

Duke sociology professor Jen’nan Read and PhD student Fatima Fairfax

Separating groups collapsed into the white category, they found that foreign-born Whites have a smaller health advantage over U.S.-born whites than is commonly assumed, and immigrants from the Former Soviet Union are particularly disadvantaged. Those immigrants report worse health, including higher rates of high blood pressure, compared to U.S.-born whites as well as people from Europe and the Middle East.

These findings illustrate how global events, such as the wars in the Ukraine and Syria, have contributed to changes in the composition of white immigrants over time.

Understanding these changes – and the distinct experiences of white immigrant subgroups – is vital to understanding long-term patterns in health disparities within the broad white category, the authors argue.

“If we truly care about reducing health disparities in this country, we need to know where the disparities are. And they get hidden when people are lumped into broad categories,” Read said. “Ukrainian immigrants, for example, we see in the news what they’re leaving. Death, destruction, their kids may have gone years now without education. This has lifelong impacts on their wellbeing. The physical consequences from stress are enormous–we know stress increases all sorts of physical health problems. High blood pressure, cholesterol, the list goes on.”

And the science is clear. The more accurate the information healthcare providers have on their patients, the better the outcomes.

“We’re missing health patterns here,” Read said. “Our country is extremely diverse, and not talking about diversity doesn’t change that fact. Health inequality costs us a lot–it costs the healthcare system and society as a whole.” 

“Health is arguably the most important indicator of how a society is doing, and paying more attention to diversity within broad categories will allow us to do better.” 

Post by Eric Ferreri, Duke Marketing & Communications

This Entrepreneur Is Changing the Way We Repair the Human Body

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A long time ago in a galaxy far, far away… Or should I say, January 23 at the Rubenstein Arts Center…? That is where biomedical engineer Nina Tandon showed us the almost magical, yet extremely precise, science of EpiBone–where personalized bones and cartilage are grown from stem cells.

Photo credit: Brown Girl Magazine

But first, it would be completely inappropriate of me to discuss Tandon’s revolutionary work without first sharing her stories from her childhood and adolescent years; that was one of the many aspects I admired about her talk–how much love Tandon shared for those who helped spark her passion for science. 

First, there was her grandmother, Dadi Ma, who at a young age wanted to study math, but unfortunately, due to the time she grew up in, was pushed away from any STEM-related field. Tandon helped complete her Dadi Ma’s dreams to pursue a STEM education. And there were the late nights in the research library with her mother; Tandon told us how she would often use her class as a group to “test how people’s memories worked, and test our (Tandon’s) classmate’s depth perception.” Then, Tandon met Dr. Maria Musarella, who helped identify her brother’s retinitis pigmentosa. And while no cure for it at the time, Dr. Musareli told Tandon how there was a team at MIT working on it–to which Tandon thought, “Maybe I’ll join that team one day.” 

Little did young Nina Tandon know just what she would do one day.

After going to school for electrical engineering, Tandon found herself working at a Bell Labs spin-off, where she learned one of the most important lessons of her life: One’s choice of job should always be “content secondary, people primary.” However, because of the new suburban area she found herself in post-9/11, Tandon felt isolated. But within this time of solace, she was able to connect the similarities between genes and data: “The axon conduction in a nerve–that’s a lot like those same equations that govern the transatlantic cable… cell membranes are 20 times higher capacitance than the best capacitors that we could build with our human hands.”

Through these observations, Tandon was able to conclude that “our bodies are the most exquisite technology we have ever been familiarized with.”

Photo credit: London College of Osteopathy

So she decided to apply to the team at MIT that Dr. Musarella had told her about years before, in which she was accepted and then joined. It was a full circle moment; Tandon was seeing herself living the dreams of the girl who would conduct experiments on her elementary school class. It should have been perfect, right?

“And I had made a mistake… I made a mistake.” She had not chosen people first and content secondary. However, as Tandon noted many times throughout her talk, it is her failures that showed her what it was she needed to do in order to succeed.

I found this aspect of the talk truly inspiring. Usually, when an extremely accomplished person talks to an eager room, they spend most of their time highlighting what they have done correctly. But here Tandon was, taking her time telling us all of the ways in which she had failed. And how those were the moments that led to her largest lessons learned. Although I can’t speak for everyone in that room, as a college student myself, there was a comfort in seeing such a successful, powerful, and kind woman telling us that we will fail… And showing us that that is the beauty in success.

So, to make an extremely long story short, Tandon then proceeded to join Robert Langer’s lab at MIT for five years, studying “how electrical signals could coax stem cells into becoming tissue,” work in a management consulting job at McKinsey & Company to learn more about entrepreneurship, and then attend Columbia for her EMBA and PhD (at the same time!). Phew, that’s a lot.

In 2014, Tandon co-founded EpiBone, in which she and her team began working in a candy factory-converted lab in Harlem. By starting with CT scans, EpiBone can make a “perfect puzzle piece-shaped biome material scaffold and a perfect puzzle piece bioreactor.”  In other words, “an environment that simulated the natural conditions for tissue development.” Within two to four weeks, Tandon and her team can grow any cartilage, bone, and joints needed throughout the body. 

Photo credit: EpiBone

Since starting her company, EpiBone has been able to grow jaw bones for six patients, which “fit perfectly and were integrated within four to six months.” This is just the beginning. EpiBone’s technology could change how we view medicine and treatment–giving patients a promise of more active lives instead of just a prescription of pain medicines.

However, as much of a miracle as this is, Tandon had to move her business’s location because of the restraining process of clinical trials within the United States, where the limited funding cannot match the necessary costs of clinical trials. Now in Abu Dhabi, Tandon has found a home for her and her family to live happily while also being in a place where she feels like EpiBone is finally starting to see a future where it can be implemented into medicine and used in patients.

Photo credit: EpiBone

Ending her talk, Tandon noted how she has learned to count her blessings, even in times when she felt like her work was not being appreciated for what it was. “It’s a shortcut for me because I’ve studied biology to be grateful… Oh my god, my heart just beat five times–that’s like a million miracles.”

Tandon has shown us that true success is not viewed from the top of the mountain, looking down at all that you have climbed, but instead, learning to appreciate and find joy in the trek to the top. I thank her, on behalf of all of the people at Duke and all who she will help in the future, for her revolutionary work in science and her honest words of inspiration.

By Sarah Pusser Class of 2028

How the body’s own defense system plays a role in Alzheimer’s disease

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Carol Colton, a distinguished professor in neurology and pathology and a member of the Duke Institute for Brain Sciences, is renowned for her groundbreaking research on the immune response’s role in the onset and progression of brain diseases, particularly Alzheimer’s disease (AD). She is a firm believer in using animals such as mice for scientific research, saying that progress in understanding and treating diseases like Alizheimer’s would not be possible without them. With a shorter life cycle than humans, mice can be studied throughout their whole life and across multiple generations. They are also biologically similar to humans and susceptible to many of the same health problems, such as Alzheimer’s. Her work has reshaped our understanding of the brain’s immune system, challenging the long-held notion that the brain is “immune privileged.” 

Carol Colton, PhD, professor of neurology and pathology at Duke

Central to Colton’s research is the role of “microglia,” the brain’s resident macrophages. Once thought to be passive observers in brain immunity, microglia are now recognized as active defenders, crucial in maintaining brain health. Colton’s early studies revealed that these cells not only eliminate harmful substances but also adapt to chronic conditions like Alzheimer’s. In this disease, microglia’s prolonged immune activity disrupts the brain’s metabolic balance, necessitating adaptations in neurons, astrocytes, and microglia themselves. She likens this adaptation to the brain coexisting with a parasite – functional but at a metabolic cost.  

Her research underscores how microglia can initially protect against Alzheimer’s by combating amyloid plaques and phospho-tau proteins but eventually contribute to the disease’s progression as metabolic disruptions intensify.

Colton’s approach integrates physiology and pathology, exploring how changes in normal physiological processes influence disease pathology. Her lab employs a variety of advanced techniques, from cellular microscopy to gene and protein analysis, to map the intricate relationships between brain metabolism and disease. This multidisciplinary approach enables a deeper understanding of how the brain’s unique environment shapes disease progression.

A cornerstone of Colton’s recent work is her discovery of “Radical S-Adenosyl domain 1 (RSAD1),” a mitochondrial protein found at the bottom of the ocean critical to understanding Alzheimer’s. RSAD1 is overexpressed in Alzheimer’s neurons, altering methionine metabolism and mitochondrial function. These disruptions contribute to the disease’s characteristic metabolic imbalance. By developing RSAD1-negative and RSAD1-overexpressing mouse models, her lab provides crucial tools to study the protein’s impact on neuronal and mitochondrial metabolism in the presence of amyloid plaques and phospho-tau.

RSAD1 also appears to be linked to methionine depletion in the brain, which may further exacerbate Alzheimer’s pathology. These findings pave the way for novel therapeutic targets aimed at restoring metabolic equilibrium in the brain.

Colton’s scientific journey is deeply influenced by her family’s academic legacy, particularly her mother, who earned a chemistry degree during an era when women faced significant barriers in science. Inspired by her mother’s determination, Colton is a passionate advocate for women scientists, often emphasizing the importance of diversity and mentorship in STEM fields.

Colton’s work highlights the slow, insidious nature of Alzheimer’s disease, driven by metabolic and immune system changes over decades. By asking fundamental questions, such as whether Alzheimer’s results from the loss of key metabolites or whether microglia contribute to this depletion, her research aims to uncover the mechanisms that underlie the disease and identify strategies for intervention.

In the fight against Alzheimer’s, Colton’s discoveries, particularly those surrounding RSAD1 and microglial activity, are setting the stage for innovative treatments. Her dedication to unraveling the complexities of brain metabolism and immune response solidifies her place as a leader in neurology and pathology, with an enduring impact on the field of Alzheimer’s research.

Post by Lydia Le, NCSSM class of 2026

Meet a Duke Expert on Pain: the Sixth Sense

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Duke associate professor of anesthesiology Andrea Nackley is a kind, passionate scientist, although her most notable quality is determination. 

As a first generation college student, a mother of two teenagers, and a triathlon athlete, she is nothing but dedicated. She challenges herself not only in a professional environment, but strives for personal and physical growth in her free time as well. 

Andrea Nackley, PhD, Duke School of Medicine

I had the pleasure of interviewing Nackley in her office and labs, where we discussed her life as a scientist, mom, and leader. When asked how she manages her many responsibilities, she responded with a single word: “acceptance.” Nackley accepts her busy schedule and strives to prioritize daily to make the most of every moment. 

As a young adult, she initially pursued the pre-med psychology path, with support from her hard-working family. She remembers a pivotal moment in her journey, in a biopsychology class where she studied brain circuits and the brain-behavior connection. She found this class absolutely riveting, and knew that this is where her passion lied. 

She describes pain, her research’s current focus, as a sixth sense of sorts, not quite like touch but something different and intriguing. Her approach to studying chronic pain is collaborative and aims to make her findings applicable to medical pursuits regarding pain management. She has even worked closely with a clinical trial centered in Duke, an experience that directly exemplifies this bench-to-bedside approach. 

A scene from the Translational Pain Research Laboratory, which Nackley leads

After earning her PhD at the University of Georgia, she moved to UNC Chapel Hill to complete a postdoctoral fellowship. In 2016 she moved to Duke, where she now leads an open-floor Translational Pain Research Laboratory and promotes an extraordinarily collaborative lab environment.

She has received grants for her work in vulvodynia, vestibulodynia, and peripheral ADRB3. When asked what her favorite aspect of working at Duke is, she endearingly responded with, “all the people here are just so… nice.” 

Nackley is close-knit with the individuals in her lab, a group ranging from high school students to postdocs, but especially with her lab manager, Marguerita Klein. 

Outside of work, she enjoys open-water swimming, training for an Olympic-length triathlon, baking, and cooking. She said baking allows her creative side to emerge, an often uncultivated aspect of any scientist’s left-dominant brain. 

Meeting Nackley and touring the innovative lab she cultivates was a wonderful experience, and I’m sure the future output from her work and leadership will be invaluable.

Post by Abigail Keaton, NCSSM Class of 2026

Invincible Insect Pests Don’t Faze This Researcher

“My passion for what I do saved my life.”

Meet Ke Dong, a biology professor at Duke University. She’s a lover of nature, a great cook, and a Lupus survivor. About 20-25 years ago, she developed Lupus during her research years at Michigan State University. Her time with this autoimmune disease was not kind. “The Lupus brought depression,” she said. 

Fortunately, she was surrounded by amazing peers and her passion: research. Dong’s research focuses on ion channels and their reaction to various toxins and stimuli. These ion channels are incredibly important to the physiology of insects because of their impact on neuronal activity. 

Duke biology professor Ke Dong.

However, her passion didn’t develop from thin air. Dong grew up on a college campus in southeastern China. With both parents leading careers as professors — her father in history and her mother in biochemistry — she had the amazing opportunity to develop her passions early in childhood. 

Growing up, she “had never been afraid of insects” as her mother’s work focused on the development of an increased production rate of silk in silkworms. However, it was the incidents in the area around her that sparked her passion. People in the area were often poisoned from the consumption of insecticides from the rice they were growing. This piqued her interest in toxicology as she was curious about how these insecticides were toxic to the townspeople. 

Combining her fearlessness in the face of insects and her interest in toxicology, Dong has found the best of both worlds.

Dong also loves to dabble in the culinary worlds of a diverse range of cultures. As she travels from country to country, she brings with her the memorable flavors of each dish she tastes. Once arriving back home, she immediately purchases cookbooks from those countries to add to her rolodex of culinary skills. As she reads each recipe on her nightstand, she dreams of ways to introduce various flavors and techniques into her dishes. A creative cook, she has no time for following measurements. Her kitchen is her sandbox and allows her to dance with each flavor in her pot, adding less sugar but a little more salt. 

Dong has been through ups and downs in her life, but there’s nothing that’s going to stop her from her passion: research. 

Post by Eubey Kang, NCSSM Class of 2025

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