Research Blog

Even before the COVID-19 pandemic, mental health challenges were the leading cause of poor life outcomes in young people. As many as 1 in 5 U.S. children aged 3 to 17 have a mental, emotional, developmental or behavioral disorder, according to the Centers for Disease Control and Prevention.

Now, that crisis has been exacerbated. Symptoms of depression and anxiety for children and adolescents have doubled during the pandemic.

Seventy percent of U.S. public schools reported an increase in the number of children seeking mental health services during the pandemic and many have struggled to meet the needs of those students, according to the latest federal data.

As the Biden administration and Congress consider policies and programs that could help curb these mental health challenges that children face, a group of Duke researchers may already have one answer.

Eighteen years after administering an intensive childhood intervention program called Fast Track, a group of Sanford School of Public Policy scholars has found that it not only proved effective at reducing conduct problems and juvenile arrests in childhood, it also improved family outcomes when the original children grow up and become parents themselves.

Their followup findings, which appeared in June in the Journal of Child Psychology and Psychiatry, show that girls who received the Fast Track intervention during first through 10th grades had improvements in several aspects of their family environments 18 years later.

Specifically, Fast Track reduced food insecurity in the mothers’ family environments, and lessened the mothers’ depression, alcohol and drug problems, and their use of corporal punishment.

“We knew the Fast Track early childhood intervention was successful at reducing aggressive behavior in childhood and criminal arrests in young adulthood,” said Drew Rothenberg, research scientist at the Duke Center for Child and Family Policy and lead author on the study.

“This research demonstrates that the early intervention doesn’t just benefit the children receiving the services,” he added. “It also improves the family environments those child form as adults, benefiting their own children. In other words, it looks like the effects of early intervention can ripple across generations.”

According to Rothenberg, the beneficial effects of Fast Track are just as large as those seen in prevention programs that only affect a single generation.

“Impressively, these beneficial effects were also almost as big as those seen immediately after the end of the Fast Track intervention 18 years earlier,” Rothenberg said. “Therefore, for mothers, Fast Track’s effects appear powerful across two generations of homes and are much longer-lasting than previous research suggested.”

“Surprisingly, the benefits of the Fast Track intervention on family environments formed as adults found for mothers did not extend to fathers,” said study co-author Jennifer Lansford, research professor at the Duke Sanford School of Public Policy and director of the Duke Center for Child and Family Policy.

Jennifer Lansford, Director of Duke Center for Child and Family Policy

“Even in contemporary society, women are still tasked with a greater proportion of child-rearing responsibility, and still more often called to create family routines and climate,” Lansford said. “Therefore, the beneficial Fast Track effects on reducing corporal punishment and increasing family food security may emerge only in mothers because mothers are still primarily responsible for the provision of parenting and procurement of resources for family meals, and consequently more likely to benefit from such intervention.”

Rothenberg said the findings suggest childhood mental health interventions can break maladaptive cycles and promote the development of healthy family environments when those children grow up and start their own families.

“With this evidence, we also demonstrate that investing in early childhood interventions won’t just pay off for today’s children but also for generations of children to come,” Rothenberg said.

Researchers surveyed 400 Fast Track participants who were now parents at age 34 about aspects of their current family environment. They wanted to assess whether parent substance use problems, depression, romantic partner violence, parent warmth, parent use of physical aggression and corporal punishment, family chaos, and food insecurity were better for adults who had participated in Fast Track as children than for adults who had been in the control group.

“We designed the Fast Track program to improve emotional awareness and interpersonal competence among children at high risk for peer conflict, antisocial and delinquent behaviors and life-course failure,” said study co-author Kenneth Dodge, the William McDougall Distinguished Professor of Public Policy Studies at the Duke Sanford School of Public Policy. Dodge is a member of the Conduct Problems Prevention Research Group that created the Fast Track program.

Participants had been drawn from high-risk elementary schools in Durham, North Carolina, Nashville, Tennessee, rural Pennsylvania and Seattle, Washington. Starting in first grade, students were randomly assigned to either receive Fast Track or be followed as a control group. Students who received the Fast Track intervention received social skills training, tutoring, and a social-emotional learning curriculum taught by teachers. Their parents received training in techniques to help the students manage their behavior.

The Fast Track project has been supported since 1991 by National Institute of Mental Health (NIMH) Grants R18MH48043, R18MH50951, R18MH50952, R18MH50953, R01MH062988, K05MH00797, and K05MH01027; National Institute on Drug Abuse (NIDA) Grants R01DA016903, K05DA15226, RC1DA028248, and P30DA023026; National Institute of Child Health and Human Development Grant R01HD093651; and Department of Education Grant S184U30002.

CITATION: “Intergenerational Effects Of The Fast Track Intervention on the Home Environment: A Randomized Control Trial,” William Andrew Rothenberg, Jennifer E. Lansford, Jennifer Godwin, Kenneth A. Dodge, William E. Copeland, Candice L. Odgers, Robert J. McMahon, Natalie Goluter, and Conduct Problems Prevention Research Group. Journal of Child Psychology and Psychiatry, June 15, 2022. DOI: 10.1111/jcpp.13648

Post by Sarah Brantley, communications director for Duke’s Center for Child and Family Policy

Behold: the Cell’s Skeleton in Motion

By Robin Smith

On June 25, 2022

In Biology

To many of us, cells are the building blocks of life, akin to bricks or Legos. But to biologist Regan Moore, a former Ph.D. student in Dan Kiehart’s lab at Duke, cells are so much more: they’re busy construction sites, machinery and materials moving about to build and shape the body. And now, new live imaging techniques make it possible to watch some of the nano-scale construction in action.

In time-lapse videos published this month, Moore, Kiehart and colleagues were able to peer inside cells as they filled a hole in the back of a developing fruit fly, a crucial step in the fly’s development into a larva. The process is coordinated with help from a thin mesh of protein fibers just under the cell surface, each one 10,000 times finer than a human hair. The fibers help the cells hold their shape, “kind of like rebar in concrete,” Moore said.

But unlike rebar, she added, “they’re constantly moving and changing.” Normally, features like these are too small and quick to see with conventional microscopes, which can only take a few images a second or are too out-of-focus. So Kiehart’s team used a technique called super-resolution fluorescence microscopy to track individual fibers with nanoscale resolution.

By watching the “rebar of the cell” at work during this hole-closing process in fruit flies, the researchers hope to better understand wound healing in humans, and what goes awry for children with birth defects such as cleft lip and spina bifida.

LEARN MORE: “Super-resolution microscopy reveals actomyosin dynamics in medioapical arrays,” Regan P. Moore, Stephanie M. Fogerson, U. Serdar Tulu, Jason W. Yu, Amanda H. Cox, Melissa A. Sican, Dong Li, Wesley R. Legant, Aubrey V. Weigel, Janice M. Crawford, Eric Betzig, and Daniel P. Kiehart. Molecular Biology of the Cell, July 15, 2022. DOI: 10.1091/mbc.E21-11-0537

Modeling Biology: Ruby Kim’s Research on the Math of Physiological Cycles

By Cydney Livingston

On May 25, 2022

In Biology, Mathematics, Students

What lies at the intersection of mathematics and biology? Freshly-minted math PhD Ruby Kim and her work on mathematically modeling human dopamine cycles.

Kim’s work has centered around her creation of a math model to predict how a person’s dopamine levels ebb and flow over the course of a day “to understand the general mechanics of how disruptions in the (biological) clock lead to disruptions in dopamine.”

She said there is a pretty long history of mathematicians using differential equations to see how different clock genes and proteins change over the course of a day’s circadian cycle. Yet, no previous models have connected the circadian clock – controlled by the brain’s suprachiasmatic nucleus – to dopamine levels. And Kim tells me that work suggesting dopamine changes throughout the day are likely controlled by the internal circadian clock itself is “relatively new.”

The first step in Kim’s work was validating scientists’– or “experimentalists,” as Kim dubs them – hypotheses about dopamine and dopaminergic enzyme cycling.

Many physiological processes are controlled via circadian rhythms and the internal clock in humans, as well as other organisms.

“But I’d like this work to help experimentalists go one step further and be able to test out hypotheses more easily.” For example, Kim says that her model has the potential to reveal other fascinating phenomena, such as how drug treatments or different genetic mutations may impact circadian rhythm or dopamine. This is thanks to the multifaceted layers of Kim’s model.

“From a mathematical perspective, the math model is very interesting. It has a lot of interesting dynamics,” she says. “Not only does it show nice, 24-hour rhythms, it shows both steady state behavior… but then also behavior that’s really wild – something called quasi-periodic behavior, where the internal clock is significantly different than the external 24-hour light-dark cycle.”

“This leads to oscillatory behavior that’s not periodic,” she says. These sorts of quasi-periodic behaviors have been observed in experiments and misunderstood, but they can be computed.

Kim emphasized the experimental and clinical implications of her work. Dopamine is involved in learning and motivation and is also linked a plethora of psychiatric conditions like Parkinson’s, ADHD, and schizophrenia. “Patients with these conditions often also experience circadian disruptions,” Kim says. “That’s a pretty big symptom.”

Kim began her academic career in her home state of California at Pomona College as a pre-med math major. “I had always been intrigued by human physiology. And math was one of the subjects I was also pretty drawn to. I just didn’t appreciate it much because throughout high school and the beginning of undergrad, I didn’t see any direct applications,” Kim told me.

The marriage of her love for math with her intrigue in biology actually began at Duke when Kim attended a mathematical biology workshop during the summer after her sophomore year. “I had never heard of math biology before that.”

After working on a brief project to model sleep apnea in infants at the workshop, Kim returned to California and took up math modeling courses in her following semesters of undergrad. One of her professors, Ami E. Radunskaya, PhD, was extremely supportive and introduced Kim to a lot of “cool biological problems.” Kim went on to do research with Radunskaya, modeling tumor-immune interactions. This experience, Kim says, “kind of just threw me into academia.” The project gave way to an undergraduate thesis with Radunskaya that analyzed the long-term behavior of this tumor growth and treatment model.

Radunskaya then suggested that Kim pursue grad school. “I kind of applied on a whim,” Kim said, “It wasn’t something I had specifically imagined for myself.” Kim mentioned how no one from her home community had really ever gone to grad school and so it was not something she had ever “explicitly” thought about before.

Using mathematics to fight cancer | Department of Mathematics | University of Washington — An abstract of Radunskaya’s work on mathematical modeling and understanding tumor-immune interactions to address cancer.

In her search for a graduate program, Kim applied to math programs, as well as those that were interdisciplinary. “I ended up choosing Duke because I really liked my advisor,” Kim told me. While Kim’s advisor Michael Reed, PhD “does a lot of interesting math,” Kim wanted to work with him because math isn’t his focus – understanding “really complex biological systems using mathematical language is.”

“A lot of times you see people who do things at the intersection of math and biology that are more motivated from a mathematical standpoint … that’s just not what I’m interested in personally. I’m very interested in finding an interesting biological problem and then applying whatever mathematical tools I have.”

While at Duke, Kim was foundational to founding the university’s chapter of the Association for Women in Math (AWM). During her undergrad, Kim “had a really great experience with AWM,” finding both a community of women mathematicians and a network of women professors who were involved in the chapter.

At Duke, there wasn’t a chapter “but quite a few people who were interested in starting and being part of one.” This organization, which is open to people of any gender identity, heads mentorship programming that brings undergrads, grad students, postdocs, and professors together, organizes conferences, and contributes to their central focus of community building in math.

Events – Association for Women in Mathematics (AWM) — Example flyers of the events organized by the Duke chapter of the Association for Women in Mathematics.

Outside of her research, Kim spends most of her free time taking care of foster pups, which she describes as “extremely rewarding but also very tiring.” Her most recent foster, a four-month-old puppy, eavesdropped on our interview as he took a nap.

This fall, Kim will begin a post-doc with the University of Michigan’s math department as she “wanted to keep studying circadian rhythms with faculty who are really great in that area.”

Post by Cydney Livingston, Class of 2022

Symposium Explores How People and Nature are Inextricably Entwined

By Guest Post

On May 13, 2022

In Animals, Anthropology, Climate/Global Change, Environment/Sustainability, Global Health, Students

The massive Keeler Oak, a white oak (*Quercus alba*) in New Jersey.

An April symposium at Grainger Hall, People and Nature, brought a diverse set of speakers, both from Duke and other U.S. institutions, to examine the relationship between human culture and land and to discuss pressing issues such as environmental justice. The session was organized by PhD students Nicholas School of the Environment and the biology department.

Professor Paul Manos of Duke Biology told us how oaks, ubiquitous tree species in temperate regions, can make people think about nature. A walk in the woods looking at the different oaks can result in a fascinating journey of natural history. For those who are curious enough, an inquiry into the lives of oaks will take them deep into topics such as evolutionary history, leaky species boundaries, plant-animal interactions, among others, Manos said. Keeping true to the theme of the symposium, Manos explored some hypotheses about the first time that humans had contact with oaks, and how this relationship unfolded ever since.

Associate Professor Orou G. Gaoue of the University of Tennessee, Knoxville, took us through a detailed case study of human and plant interactions with long-term data from the country of Benin, in Africa. He showed how the harvest of the African mahogany (Khaya senegalensis) affects human demography and even the marriage dynamics of the Fulani people, with many other insights into the intertwined relationship of the locals and their harvest.

Central to the morning sessions were the rights of nature and the granting of personhood to non-humans, which is common in the cosmology of many indigenous cultures. For instance, Andrew Curley, assistant professor at the University of Arizona, mentioned in his talk that the O’odham people in the Sonoran Desert confer the Saguaro cactus personhood status. His talk exposed how colonial dynamics have created climate catastrophes and drought around the Colorado River, how indigenous peoples have to navigate these foreign systems, and how they understand their relationship with the land and water.

Michelle Carter, a first-year Masters of Environmental Management (MEM) student at Duke, examined the feasibility of the rights of nature in the US legal system. These rights allow certain natural features (e.g. rivers) to stand as a sole party in litigation and recover damages on their behalf. However, effective application and the enforcement of policy have been lacking.

The second part of the symposium focused on environmental justice. Duke Ph.D. student Maggie Swift presented a land acknowledgement which was divided into three parts: recognition of the violent history of the past; an understanding of the present with a celebration of the lives and achievements of current indigenous peoples; and a call to action so that participants were encouraged to financially support native-led organizations. Links for donations and more information can be found on the symposium website. The land acknowledgement was followed by a brief presentation on the project Unearthing Duke Forest that explores the human history surrounding Duke Forest.

Why is it important to jointly consider people and nature in your work? What insights do you gain in your work by taking this approach?
People & NAture

Christine Folch of Duke Cultural Anthropology

Assistant professor Christine Folch, from Duke’s Department of Cultural Anthropology provided an analysis of the discourse around climate change. At the center was the question “do you believe in climate change?” which has ingrained the element of doubt and the ability of the speaker to say “no, I don’t.”

Associate professor Louie Rivers III, from NC State University, gave a talk on perceived environmental risks and their influence on social justice. He pointed out that these questions could be dismissed by certain groups such as black farmers, who are concerned and disproportionally affected by environmental issues but might not relate to how the question is addressed.

Sherri White-Williamson, Environmental Justice Policy director at NC Conservation Network, explained the concept of environmental justice and provided concrete examples of how certain policies (e.g. federal housing/lending policies or interstate highway systems) can create inequalities that leave communities of color to bear the exposure of environmental degradation. She also made us aware that this year is the 40^th anniversary of the birth of the US environmental justice movement that started when an African-American community in Warren County, North Carolina organized to fight a hazardous waste landfill.

No exploration of people and nature would be complete without including the seas. A team of three students at the Duke University Marine Lab, undergrad Maddie Paris, second-year MEM Claire Huang, and Ph.D. student Rebecca Horan, presented two case studies of social and ecological outcomes linked to education and outreach interventions conducted in tropical marine environments.

Their first case study was on turtle education in Grenada, West Indies. Here a 10-week summer program for local children ages 9-12 created an improved understanding of marine turtle biology and its connection to the health of the ocean and their communities. The second case study was a 4-week training course for fisher people and fisheries officers in Mtwara, Tanzania. These participants increased their skills in monitoring the local reefs and were better equipped to educate their communities on marine environmental issues.

The symposium ended with two open questions for the audience, which should be considerations for anyone doing environmental research: Why is it important to jointly consider people and nature in your work? What insights do you gain in your work by taking this approach?

Guest post by Rubén Darío Palacio, Ph.D. 2022 in Conservation Biology from the Nicholas School of the Environment, and science director of conservation non-profit Fundacion Ecotonos in Colombia.

A Fond Farewell for Our Three Senior Bloggers

By Karl Bates

On May 4, 2022

In Art, Neuroscience, Science Communication & Education, Students

It’s May! Time for our 2022 Duke graduates to endure Pomp and Circumstance on repeat, shed a tear, and then take wing. Always bittersweet for those of us who work with students.

This year, the Duke Research Blog celebrates the graduation of three outstanding student-bloggers. This class produced some real gems and we will be greatly diminished by their commencement.

This image has an empty alt attribute; its file name is IMG_1940.jpg — Anna Gotskind in the Galapagos, 2018

Anna Gotskind blogged for us all four years, after growing up in Chicago.

Most memorably, Anna took us along when she spent the summer of 2019 at an archaeology dig in Italy.

Her other topics were a liberal arts education in themselves: she wrote about invisible malaria, climate change, dance, drinking water standards, snow leopards, muscular dystrophy, cybercrime, autism and some fascinating classmates. This year, as she readied for her career, she wrote a three-part series about blockchain and bitcoins.

After graduating with a psychology major, an econ minor and an innovation and entrepreneurship certificate, Anna will be moving to Atlanta to work as an associate consultant at Bain and Company. She plans to continue learning about the web3 space in her “free time” and hopes to find an outlet to continue writing about cryptocurrency as well.

Cydney Livingston, the pride of Anson County, NC, joined us as a sophomore and proceeded to shoot out the lights with 31 career posts.

Cydney’s biggest hit, by far, was her first-person account of trying to continue with college after the pandemic shut down Spring Term, 2020. “Wednesdays, My New Favorite Day,” appealed to Duke alumni, family and friends everywhere who were wondering what the heck was going on in Durham. Short answer: It was weird.

She was integral to our (mostly virtual) coverage of the COVID crisis, and helped the campus keep up with some of the larger questions the emerging virus presented, including social inequity and vaccine hesitancy. She also profiled some grad students, sharing a look inside their worlds from a student’s perspective. And in between, Cydney saw paleontologist Richard Leakey in one of his last public appearances and wrote about space junk, cervixes, lead poisoning, dog smarts, visual perception and North Carolina’s pungent pork industry.

Cydney is graduating with a BS in Biology and an AB II in History and is moving to Boston in the fall to begin work as an analyst with ClearView Healthcare Partners. But she is leaving open the possibility of a return to academia in history of science, technology and medicine, or science and technology studies. “I’m excited to spend a few years working and reflecting on my time at Duke and what lies ahead in my life journey.”

Rebecca Williamson, a first-year economics, but maybe arts major, signed up four years ago just for the experience and horizon- broadening. Mission accomplished! She’s graduating with distinction as an English major with minors in Econ and Music. Her blogging career covered The Muppets, grad student standup comedy, and the exhausting Datathon hackfest.

She will be staying in Durham to take part in the Analyst Program for DUMAC, the nonprofit corporation that manages the university’s investments.

Godspeed, young bloggers. We miss you already.

Written with fondness and gratitude by Karl Leif Bates, editor

Vernal, Ephemeral, Spring Beauty by Any Other Name

By Sophie Cox

On April 5, 2022

In Biology, Environment/Sustainability, Faculty, Field Research, Science Communication & Education, Students

Nicki Cagle, Ph.D., with perfoliate bellwort, an ephemeral forest plant also known as wild oats (Uvularia perfoliata).

“Ephemeral” is one of my favorite words. It conjures up images of vernal pools and fireflies and flowers in spring. It comes from ephēmeros, a Greek word meaning “lasting a day.” English initially used it in a scientific sense, to refer to fevers and then in reference to short-lived organisms like flowers or insects. Today “ephemeral” is most often used to describe anything fleeting or short-lived.

The term “spring ephemeral,” for instance, refers to flowers that are visible for only a short time each spring before they disappear.

Nicki Cagle, Ph.D, a senior lecturer in the Nicholas School of the Environment, led a spring ephemeral workshop in the Korstian Division of Duke Forest on a Friday afternoon in late March. The workshop was hosted by DSER, the Duke student chapter of the Society for Ecological Restoration. We focused on identifying herbaceous plant species and families, particularly spring ephemerals.

“Spring ephemerals are perennials that emerge early in the spring and then grow, reproduce, and disappear from the surface of the forest floor in just a few short weeks,” Cagle explains. We also found several species that aren’t technically ephemerals but still bloom in early spring — before the tree canopy emerges and plunges the floor into shade.

Oxalis violacea, a species of wood sorrel.

The first plant Cagle points out is Oxalis violacea, a type of wood sorrel. “This particular species will have purple flowers,” she says. The genus name, Oxalis, refers to the plant’s oxalic acid content. “You can nibble on it,” but “you don’t want to nibble on it too much.” Oxalic acid, which is also found in common foods like spinach, gives the leaves a pleasant, lemony taste, but it can cause problems if eaten in excess.

When we come across a patch of lovely, pale violet flowers with yellow centers, Cagle challenges the workshop participants to determine which family it belongs to. She offers two options: Rubiaceae, a large family that often has either opposite or whorled leaves and four to five petals and which includes familiar plants like coffee, or Violaceae, a very small plant family whose members “tend to have everything in fives” (like petals, stamens, and sepals) and often have basal leaves. Answer: Rubiaceae. This particular species is Houstonia caerulea, the common bluet. Its yellow centers help distinguish it from related species like the summer bluet, tiny bluet, and purple bluet. If anything, Cagle says, the plant’s presence is “an indicator of disturbance,” but it’s still good to have around.

Here’s the little brown jug (Hexastylis arifolia).

Next we come across two species in the Hexastylis genus. They are sometimes called wild ginger, but the name is misleading. Hexastylis species are not related to the ginger you buy in the store, which is in a completely different family. Hexastylis is, however, in the same family as the Asarum genus, which Cagle thinks of as “proper” wild ginger. Asarum and Hexastylis have traditionally been used as food and medicine, but they also contain toxins. According to Cagle, they belong to “one of the few plant families that have fossilized remains in the United States,” even dating back to the late Cretaceous Period.

The two species we see are Hexastylis arifolia, the little brown jug, and Hexastylis minor which looks similar but “tends to have a much more rounded form.” Like many spring ephemerals, Hexastylis is often dispersed by ants. The seeds have elaiosomes, fatty deposits that ants find attractive.

“We have a lot of different violets of varying origins” in this area. According to Cagle, this one is likely to be a common blue violet, Viola sororia.

There’s a patch of violets near the Hexastylis plants. “We have a lot of different violets… of varying origins” around here, Cagle says. Many of the native species have both a purple form and a variety that’s white with purple striping. Other species in the violet family come in different colors altogether, and Cagle says many of those are of European origin.

The Johnny-jump-up pansy, for instance, can have “funkier colors,” like yellow or pinkish purple and is native to Europe and Asia. Violets can be hard to identify. Some species are distinguished mainly by characteristics like the lobes (projections in leaves with gaps between them) or the hairiness of the leaves. The bird’s foot violet and wood violet, for example, “tend to have really deep lobes.”

Cagle says the violet we’re looking at is likely the common blue violet, characterized by smooth leaves and petals, purple or purple-and-white flowers, and rounded or slightly arrow-shaped leaves.

The Cranefly orchid (Tipularia discolor) reproduces later in the year. The purple on the bottom of the leaves, and sometimes on the top as well (see right), helps protect the plant from sunlight and herbivores.

The orchid family, Orchidaceae, is one of the largest families of flowering plants in the world. Many of its members are tropical, including the Vanilla genus, but “we do have a number of native orchids” here as well, including yellow and pink lady’s slipper orchids, putty-root, and the cranefly orchid.

The cranefly orchid, Tipularia discolor, isn’t yet in bloom, but we come across the leaves several times on our walk. According to Cagle, Tipularia discolor “isn’t actually a spring ephemeral” because it reproduces later in the year. However, “it’s ephemeral in its own way,” the leaves disappear by the time it flowers. Cagle says the plant’s scientific name can remind you what to look for: “‘Tip-’ because you’re going to tip this leaf over” to look at the underside and “discolor” because the leaves are a striking purple underneath. Some of the ones we see are purple on top as well. Cagle explains that the purple coloration serves as sunscreen and protection from critters that eat plants.

The plant gets its common name (and its scientific genus name, interestingly) from its delicate flowers, which are supposed to resemble craneflies. When the plant blooms, “the flowers are so delicate and so subtle that most of the time you miss them.” Pollinators like Noctuid moths, on the other hand, find the flowers easily and often. Cranefly orchids even have “specialized seed structures” that “get fused onto insects [such as the moths]… and carried off.”

Rue anemone (Thalictrum thalictroides or Anemonella thalictroides).

Cagle with giant chickweed (Stellaria pubera).

The rue anemone, unlike the cranefly orchid, is a true spring ephemeral. It belongs to a more “primitive” family and has lots of petals in a spiral arrangement. The species is also known as windflower “because they flutter and dance as the breeze comes through.” Cagle mentions that the plant is “usually pollinated by flies and little bees” and serves as an important food source for insects in early spring. But “how do these even exist” in a forest with so many plant-eating deer? Many spring ephemerals, Cagle explains, have “some really potent toxins” that protect them from large herbivores.

We stop briefly to examine perfoliate bellwort, also known as wild oats (Uvularia perfoliata), and giant (or star) chickweed. Chickweed is in the pink family, named not for the color but because “the petals… [look] as if they’re cut by ‘pinking shears,’” which have saw-toothed blades that leave notches in fabric.

Trout lily (Erythronium umbilicatum). According to Cagle, “No spring ephemeral walk is actually complete without finding some trout lilies.”

Near the end of our walk, we find several trout lilies. That’s fortunate. “No spring ephemeral walk is actually complete without finding some trout lilies,” Cagle says.

Unsurprisingly, trout lilies belong to the lily family. “Their flower structure,” Cagle says, “is very symmetrical” with three petals and three sepals. In trout lilies, the sepals resemble petals, too. This particular species is Erythronium umbilicatum. The species name, umbilicatum, refers to its “really long peduncle,” or flower stalk, which “allows the seed to actually touch the ground.” The seed is dimpled, Cagle says, “like a little belly button.” The name “trout lily,” meanwhile, refers to the mottled pattern on the leaves.

At the base of a tree near a small river, Cagle points out a flower called spring beauty (Claytonia virginica), “a quintessential spring ephemeral.” Some flowers, like the common bluet we saw earlier, thrive in disturbed areas, but plants like the spring beauty need rich, undisturbed habitat. That makes them good indicator species, species that can help scientists gauge environmental conditions and habitat quality. When a natural area is being restored, for example, scientists can measure restoration progress by comparing the “restoration site” to an undisturbed “reference site.”

According to Cagle, the spring beauty is pollinated by “bee flies… flies that kind of look like bees.” After pollination, the flowers turn pink. Cagle says this is common among ephemerals. One theory is that the color change signifies which flowers have already been pollinated, but others think it’s just a result of senescence, or aging.

Spring beauties are also “photonastic,” meaning they open and close in response to changing light conditions. “There is some evidence that the Iroquois would eat this plant in order to prevent conception,” Cagle says, but today the plant—like many spring ephemerals—is under protection in some areas. Human activities, sadly, have contributed to the decline of too many spring ephemerals.

Alum root (Heuchera americana) near the end of the walk. According to Cagle, its roots can be used “to form mordant for dyes.” Members of the Saxifrage family, which includes alum root, often have five petals, five sepals, and five stamens.

Not all of the plants we saw are spring ephemerals. Some, although they bloom in early spring, “wouldn’t technically be considered ephemeral because their leaves stick around even if their blooms don’t last long.” True ephemerals, on the other hand, “are plants that just seem to disappear off the face of the planet (or the forest floor) after a few weeks,” Cagle says. Only three of the species we found during the workshop are true ephemerals: the windflower, trout lily, and spring beauty. However, these aren’t the only spring ephemerals found in the area. Cagle’s personal favorite is bloodroot, with its “bright white petals” and pollen “that looks like it’s glowing.”

Next time you’re in the woods, keep your eyes out for ephemerals and other early spring flowers, but look quickly. They won’t be here for long.

Post and Photos by Sophie Cox, Class of 2025

“Brains are Weird… and the World is Difficult”

By Sophie Cox

On March 30, 2022

In Behavior/Psychology, Business/Economics, Computers/Technology, Mathematics, Science Communication & Education

Institute for Consumer Money Management, and Duke University’s Center for Advanced Hindsight.

Intending to do the right thing doesn’t always lead to actually doing it, a tendency formally known as the “intention-behavior gap.” We can intend to go to bed early and still go to bed late. We can want to exercise and still choose not to. We can recognize the importance of saving extra money and still choose to spend it instead. So why is it so hard to change our behavior? Because, says Jonathan Corbin, Ph.D., “brains are weird” and “the world is difficult.”

Corbin is a senior behavioral researcher at the Center for Advanced Hindsight at Duke University. The Center for Advanced Hindsight recently partnered with NOVA Labs, Thought Cafè, and the Institute for Consumer Money Management to create the NOVA Financial Lab, a group of financial literacy games targeted at adolescents and emerging adults. In each game, players practice managing money while taking care of a pet. You may never have to sneak a cat into a concert or prepare a retirement plan for a dog in real life, but you will need to understand concepts like budgeting, interest, and debt. “What we hope people start to do,” Corbin says, “is really think about, ‘What decisions should I make now to make better decisions later?’”

Essentially, “Money spent now is money that can’t be spent later.” As intuitive as that might seem, “The way we think about money is relative, and it’s not linear.” When you’re already spending thousands of dollars on a car, for instance, an extra five hundred dollars for a feature you may or may not need “feels like a very small amount of money,” but in a different situation, its value can seem higher. How many times, Corbin points out, could you go out to eat with five hundred dollars?

The three games combine financial literacy with behavioral science to explore why people make the decisions they do and how they can start to make better ones.
Source: https://advanced-hindsight.com/wp-content/uploads/2022/03/CAH-NOVA.pdf

There are three games: Shopportunity Cost, Budget Busters, and Exponential Potential. (“One of the people from PBS helped us come up with these cute names,” Corbin says.) They each involve different skills, but they all focus on “financial literacy from a behavioral science perspective.” Players have to contend with both external obstacles and common behavioral biases to make financial decisions for a pet. “I always choose the dog,” Corbin adds, “but I understand other people might choose the cat.” (I chose the cat.)

The first game, Shopportunity Cost, focuses on short-term financial planning. It involves dressing a pet up like a person in order to sneak them into a concert for the night. “You have to make decisions that optimize the pet’s happiness while also being able to make it to the concert and back home,” but you have a limited amount of money to spend. If you spend too much money too soon, you’ll run out, but if you’re too frugal, your pet won’t enjoy the evening. As goofy as the concert scenario is, it introduces players to an important concept known as opportunity cost, which refers to the potential benefits we miss out on when we choose one alternative over another. Say you’re debating between a $50 outfit and a $30 one. The opportunity cost of choosing the more expensive outfit is $20, but shoppers don’t always consider that. “Opportunity cost neglect is the simple idea that when we’re faced with financial decisions, we tend not to consider alternative uses for that money.” Reframing the $30 outfit as “a $30 dress that I’m okay with plus 20 extra dollars” that could be spent elsewhere might lead you to choose the cheaper outfit. Or it might not. “Sometimes you want the $50 outfit, and that’s perfectly fine… but a lot of the time that might not be the right decision.” Like many things, taking opportunity cost into account is a balancing act. “We shouldn’t obsess over every possible opportunity that there is,” Corbin cautions, but “consider[ing] opportunity costs can lead to better financial decisions.”

Budget Busters, meanwhile, involves medium-term planning. Players have to manage checking, credit, and savings accounts while caring for their pet over a six-month period. Along with purchasing essential and non-essential items to attend to their pet’s basic needs and happiness, players have to contend with unforeseen circumstances like medical emergencies. The game introduces people to the 50-30-20 rule, a budgeting concept that involves devoting 50% of income to essentials, 30% to non-essentials, and 20% to savings. Budget Busters also explores the principle of mental accounting, the idea that aside from formal budgets, we have “categories in our head” that change our perception of money. “Let’s say you get birthday money from your relative. That money tends to be a different kind of spending money to you than money you get from your paycheck,” Corbin explains, because “money feels different in different contexts.”

There are parallels in Budget Busters. Sometimes players receive unexpected windfalls like gifts or prizes. (My cat won $40 for being “Best in Show” at the local pet pageant.) Players get to decide whether to use the extra money on a “fun” item for their pet or put it into savings. Corbin says “gift money” is a classic example of a misleading mental account. “We tend to overspend… because it feels like it’s not even our money in a way.” In reality, though, money has “fungibility,” meaning it’s “exchangeable… across any account.” In other words, “money is money,” regardless of where it comes from. A $10 bill, for instance, can be exchanged for two fives without changing its value. (Non-fungible tokens, or NFTs, lack this property. “You can’t exchange the picture of a cat you bought from the internet for Chipotle.”) Like Shopportunity Cost, Budget Busters focuses on both traditional financial concepts and common behavioral tendencies that affect decision-making. “None of these things are necessarily bad,” Corbin emphasizes, “but they’re things that one should be aware of… when that natural proclivity may be swaying them in the wrong way.”

Budget Busters, which focuses on monthly budgeting, also encourages players to look closely at discounts when shopping. “Sometimes the discount that looks really good from a percentage-off perspective isn’t actually the better discount” in terms of overall budgeting and total amount of money saved, Corbin warns.

The last game, Exponential Potential, explores concepts like compound interest, debt, and investment. The premise of the game involves traveling back in time to balance debts and investments. The goal is to make your pet a millionaire. By showing players how investment decisions can affect future net worth, the game seeks to increase understanding of processes involving exponential growth. Exponential Potential introduces the concept of exponential growth bias. According to Corbin, “We tend to underestimate things that grow exponentially.” He cites the coronavirus pandemic as an example: “Even the people who were making the graphs of Covid’s growth… it’s really hard for them to figure out how to show that to people.” Log-transformed graphs are one option, but they can be deceptive by making the slope look flatter. Similarly, when dealing with exponential growth in the financial world, “People are going to underestimate how badly they’re going to get burned” by debt, but they may also underestimate how much they’ll benefit by saving for retirement.

With compound interest, for instance, “The interest gets applied both to principle and to interest from the last time, and that’s where exponential growth happens.” In the game, players have the opportunity to adjust how much money to put toward paying off debts, investing, and saving for retirement each month. Then they travel decades into the future to see how their decisions have affected their pet’s net worth. “We’re hoping that that kind of feedback allows you to think through… what you might have done wrong and try to correct,” Corbin says. Once again, though, raw numbers aren’t the only factor at play. “We just want people to understand what the optimal way to do this is, and if there’s a better way for them to do that psychologically, that’s fine.” Debt account aversion, for example, refers to the fact that people want to have fewer debt accounts, meaning they are often eager to pay off accounts in full when they can. Some financial advisers suggest that “because they think it’ll get the ball rolling and you’ll be more likely to pay off the next one.” According to Corbin, there isn’t a lot of evidence for that, and sometimes paying everything off at the outset isn’t ideal. For instance, “It is optimal to start thinking about retirement as soon as you can… but if you’re delaying putting money into retirement because you’re so concerned with your student loan debt,” that can be problematic. Still, Corbin understands the appeal of closing debt accounts. “I am risk-averse, which means if I have a debt I’m probably going to put more money toward that debt that I necessarily should given what the interest rates are and what I could potentially make by investing that money instead.” Financially speaking, “There’s a decent likelihood that I should just pay the minimum on my mortgage… [but] I’ve decided I’m willing to trade off those future gains for the peace of mind that if something goes wrong… I’ll be ahead on my mortgage payment.” Even in Exponential Potential, the right choices aren’t always clear-cut. Corbin describes it as a “sandbox approach” where players are given more opportunity to play around. “This is the trickiest game because there’s no perfect answer for anything,” he says. “Everything has risk.”

Another bias that can affect our financial decisions is known as present bias, the tendency to discount the future in favor of the present. Corbin offers the everyday example of staying up too late. “Nighttime Me wants to stay up and read…. Morning Me is going to be really ticked off at Nighttime Me when they’re exhausted and don’t want to get up.” Research suggests that people can have a harder time identifying with their future selves. That can easily affect our financial decisions, too. “I’m going to let future me worry about that. That guy. Whoever that is.” However, “If you can get people to identify more with that person,” they can sometimes make better decisions. Ultimately, “The game isn’t trying to force people to become investment robots.” We are biased for the present because we live in it, and that’s normal. The purpose of the game is simply “to nudge people… to worry just a little more about the future.”

“Money is basically for safety, security, and happiness,” Corbin says. The ultimate objective is to balance needs, wants, and savings to achieve those three goals both in the present and the future.

Kinsie Huggins: the Future Doctor Who Could Shot-Put

By Camila Cordero

On March 29, 2022

In Biology, Cardiology, Data, Field Research, Genetics/Genomics, Global Health, Medicine, Policy, Students

From shot-putting, to helping conduct two research studies, to being selected for a cardiology conference, meet: Kinsie Huggins. She is from Houston, Texas, currently majoring in Biology and minoring in Psychology with a Pre-Med track here at Duke. With such a simple description, one can already see how bright her future is!

“I want to be a pediatrician and work with kids,” Huggins says. “When I was younger, I lived in Kansas, and in my area, there were no black pediatricians. My mother decided to go far to find one and I really bonded with my pediatrician. One day, I made a pact with her in that I would become a pediatrician too so that I can also inspire other little girls like me of my color and other minority groups.”

Having such a passion to let African-American and minority voices be heard, Huggins is also part of the United Black Athletes, using her shot-put platform to make sure these voices are heard in the athletics department.

And while she may be a top-notch sportswoman, she is also just as impressive when it comes to her studies and research. One of her projects focuses on the field of nephrology – the study of kidneys and kidney disease. She and a pediatric nephrologist are currently working on studying rare kidney diseases and the differences in DNA correlating to these diseases.

Kinsie is also a researcher at GRID (Genomics Race Identity Difference), which studies the sickle cell trait in the NCAA. With the sudden deaths of college athletes from periods of over-exhaustion during conditioning, there has been a rise in attention of sickle cell trait and its impact on athletes. At first, the NCAA implemented a policy that made it mandatory for college athletes to get tested for sickle cell in 2010, but some were wary about the lack of scientific validity in such claims. Now, the NCAA has funded GRID to conduct such research.

_{The difference of Normal red blood cell and sickle cell (CDC).}

“We are analyzing the policy (athletes need to be tested for sickle cell), interviewing athletes in check-ups, and looking at data to see if the policy is working out for athletes and their performance/health,” Huggins explains.

With such an impressive profile, it doesn’t go without saying that Huggins didn’t go unnoticed. The American College of Cardiology (ACC) select high school and college students interested in the field of medicine and have them attend a conference in Washington D.C. to hear about research presentations, groundbreaking results of late-breaking clinical trials, and lectures in the field. Having worked hard, Huggins was selected to be part of the Youth Scholars program from the ACC and was invited to the conference on April 2-4.

Let’s wish Kinsie the best of luck at the conference and on her future research!

Post by Camila Cordero, Class of 2025

Duke First-Year Founds Cryptocurrency Security Startup, Harpie

By Anna Gotskind

On March 21, 2022

In Business/Economics, Computers/Technology, Data, Engineering, Students

“Crypto is scaling so quickly but security systems are still the same as they were in 2013.” Those are the words of Daniel Chong, a recent Duke student whose new startup aims to change that.

One of the largest challenges within cryptocurrency is security. The most impactful application of cryptocurrency thus far is decentralized finance (DeFi). DeFi eliminates intermediaries by allowing people and businesses to conduct financial transactions through blockchain technology as opposed to working through banks or other corporations. However, as a result, people are personally responsible for securing their assets.

When engaging with cryptocurrency people generally use a trading platform and a wallet. Cryptocurrency trading platforms like Coinbase, Binance, and Crypto.com allow people to buy and sell cryptocurrencies using USD or other cryptocurrencies. However, in order to use crypto, one must transfer some of it into a wallet.

As with conventional currency, crypto wallets are not required in order to use cryptocurrency but they allow individuals to store their tokens in one place, easily retrieve them and send it to other individuals or organizations (i.e. buying non-fungible tokens). Some of the most popular wallets include Coinbase wallet, Metamask, and Electrum.

These wallets are not only password-protected but provide each user with a seed phrase or a series of words generated by one’s cryptocurrency wallet. This phrase, like a password, provides access to the crypto associated with that wallet.

The catch is, if an individual gets locked out of their wallet and cannot remember or does not have access to their seed phrase, all of their money will be lost. This is a major problem in the space and people have lost millions of dollars to lost seed phrases and inaccessible wallets. In fact, 20% of all existing Bitcoin tokens have been misplaced.

Furthermore, in the past, it was already hard enough to secure one’s crypto wallets but now people have several wallets, each with their own unique seed phrase and passcodes making it all the more difficult. In the Fall of 2020, Daniel Chong, a Duke first-year at the time, identified this wallet security problem.

“Crypto is scaling so quickly but security systems are still the same as they were in 2013.”
Daniel Chong

Having grown up in Las Vegas, Chong was used to fast-paced environments and unique challenges. During high school, Chong started coding as a hobby.

“I just wanted to build something,” he explained

The first project he built was a website for a research paper he had in his high school psychology class. In 2018 Chong was introduced to solidity, a programming language that’s main purpose is to develop smart contracts for the Ethereum blockchain. If you are unfamiliar with blockchain, please refer to my previous article here.

Chong matriculated to Duke during a period of transition, the Fall of 2020. As a result of being sent home due to COVID-19 in the Spring and having to shift to online meetings, many on-campus clubs were struggling. Early on Chong met Manmit Singh, a Junior at the time and the President of the Duke Blockchain Lab.

Even though Chong was only a first-year, he had experience coding in solidity and ended up aiding Singh in revamping Duke Blockchain Lab so students could continue engaging with and learning about blockchain despite the pandemic. Additionally, he ran a virtual course on web3 and solidity development for other club members.

Despite the fact that Chong was attending classes, involved in clubs, and working part-time, he began talking to his brother Noah who was a senior at Georgia Tech about once again, building something.

After working on building a security solution for crypto wallets for about a year, Chong and his brother received venture capital funding for their startup Harpie: a simple crypto protection plan that scales with you.

Chong explained that venture capitalists are very excited about crypto right now, especially back in November of 2021 when crypto was in a bull market and bitcoin was at a market high of 60,000.

Harpie is a web app that allows users to connect all of their wallets to individualized protection plans. This means that if you have a Harpie protection plan and someone hacks your wallet or you get locked out, you can go to the Harpie web app and transfer your funds from the unusable wallet to a new one.

Additionally, users are able to choose the degree of security their Harpie account has. Users can regain access to their fund via email, phone, or (personal recommendation) 2-factor authentication. Ultimately, for $8.99/month you can protect as many wallets, with any sum of funds, as you want.

After working for just over a year, Harpie launched on February 14th, 2022. The next weekend Chong and his brother headed to ETHDenver, the largest Ethereum conference, to promote Harpie and compete in the Hackathon. For those who are unfamiliar, hackathons are competitive, sprint-like events where computer programmers and others are involved in software development work to build something over a condensed period of time.

Over 10,000 people participated in the ETHDenver hackathon in person and over 30,000 participated virtually for over $1 million in bounties and prizes, as well as up to $2 million in investment capital.

While the teams had 36 hours to build a project, Chong and his brother managed to build there’s in 4-5 hours. They did this by quickly creating a front-runner bot/flash bot to help people avoid getting hacked by detecting and halting transactions to unauthorized addresses.

The brothers not only successfully built the bot but also placed top 10 in the overall hackathon and had the opportunity to present their project.

While presenting, Chong also received questions from Vitalik Buterin, the founder of Ethereum. He explained this as a very “nerve-wracking experience” and added that Buterin asked very technical questions such as what the miners’ extractable value would be.

Chong and his brother (left) onstage with Vitalik Buterin (right) presenting at ETHDenver

In the future, Chong would be open to entering more hackathons but right now is more interested in growing his startup. Currently, Chong is taking time off from school to focus on Harpie and to, ultimately, revolutionize security systems as they relate to online assets.

“Rest easy knowing your crypto is safe.”
Daniel Chong

Poetry and Pedagogy: The Push for Humanities Education in Medicine

By Vibhav Nandagiri

On March 16, 2022

In Art, Medicine, Science Communication & Education

“If language shapes inequitable systems, then their disruption relies in part on our ability to effectively wield language in subversive ways”
Dr. Irène Mathieu, MD

Dr. Mathieu reading from her award-winning 2017 book *orogeny*

Buried within a smattering of bullet points and data nuggets, these evocative words flashed across the slide deck of Dr. Irène Mathieu, MD. As Assistant Professor of Pediatrics at the University of Virginia School of Medicine and an award-winning poet, Mathieu thinks medical students could benefit from a stronger background in the humanities. Over the course of her guest lecture, “Playing Between the Lines: Poetry by a Pediatrician,” Mathieu dropped many such pieces of wisdom linking the study of language, and more broadly the humanities, with the practice of medicine. She shared this wisdom through a variety of methods, including original poetry, anecdotes from her life, and the latest research into the field of narrative medicine. The lecture was organized by the Trent Center for Bioethics, Humanities, and History of Medicine and hosted by Dr. Sneha Mantri, MD, MS, Assistant Professor of Neurology at Duke University School of Medicine.

Published in 2016 and co-authored by Dr. Charon, “The Principles and Practice of Narrative Medicine” is considered as one of the influential works in the field.

The field of narrative medicine, hardly twenty years old, can trace its roots to Columbia University, when a group of physicians and scholars, spearheaded by Dr. Rita Charon, MD, PhD, sought to change the discourse surrounding traditional medical training. Emphasizing various humanities-based approaches, narrative medicine seeks to increase the propensity of physicians to perceive strife, uncertainty, and complexity in the pursuit of caring for complex illnesses. In her discussion, Mathieu cited multiple studies that detail the positive impact of an exposure to the humanities on the empathy, wisdom, tolerance for ambiguity, and resistance to burnout in medical students. More recent studies have shown that narrative medicine experimental training programs have similar impacts.

Like many of her contemporaries, Mathieu sees the utility in narrative medicine to impact not only the personal lives of physicians, but also the systems in which they interact. By approaching treatment through the lens of narrative medicine, she believes that physicians can better reimagine health systems into more equitable entities. In her pursuit of greater health equity, Mathieu identified two concepts that every physician should strive to possess: structural competency and critical consciousness. Structural competency, a term coined by her colleagues in an influential 2014 paper, proposes a model of patient engagement that goes beyond the realm of cultural awareness and further into understanding upstream, systemic issues such as zoning laws, food delivery systems, and health insurance. Critical consciousness, the ability to recognize the inherent contradictions and inequities within society, complements the structural competency framework. By consistently engaging in critical reading and reasoning, future physicians will be better able to reflect on the “power, privilege, and the inequities embedded within social relationships”.

While Mathieu recognized the power of narrative medicine, she also acknowledged how poetry has never had its proper place within the prose-heavy field. In her eyes, however, incorporating poetry into narrative medicine frameworks makes a lot of sense. For one, it allows a deeper level of vulnerability and dynamicity that literary fiction and theory cannot provide. More practically, however, poetry tends to err on the shorter side of literature (Mathieu calls them “multisensory micro-stories”), offering a less time-consuming alternative for busy medical students and residents.

For most of Mathieu’s life, her passion for poetry and medicine developed on parallel tracks. It wasn’t until her undergraduate years that she began to think of poetry more externally and started to seek out opportunities for publication. Around the same time, through her work in various global health initiatives, she witnessed the power words and policy can possess over the healthcare needs of entire populations. She identified a need for a humanities education, replete with poetry and theory and fiction, as critical to increasing equity within the healthcare system. When Mathieu assumed her latest role at UVA, on the eve of publishing her third poetry collection, the critically acclaimed Grand Marronage, she was given the opportunity to integrate her poetry within the university medical curriculum. Today, Mathieu has a secondary appointment as Assistant Director of the Program in Health Humanities at UVA’s Center for Health Humanities and Ethics. The parallel pathways of her life had converged.

Mathieu’s three books: *the galaxy of origins* (2014), *orogeny* (2017), and *Grand Marronage* (2019)

As Mathieu revealed during her presentation, much of her poetry has little to do with her daily medical practice. Rather, she views poetry more along the lines of an escape. This escape takes the form of a critical reflection, by connecting the quotidian with themes of family and love, excess and presence. Mathieu’s poetry has the rare ability to walk readers through her complete narrative process, from the barest of sensory details to the ambiguities of emotion.

Perhaps there is no more fitting an ending to this article than an invitation to join Mathieu’s narrative world. After all, no amount of prose can substitute for a real poem. Below is a particularly striking excerpt of Mathieu’s artistry from the first stanza of her poem, “the forest fire of family trees”:

the problem is we don't know
that many ways of doing things
for instance, neither of us can
fry an egg without public radio
chattering in our ears, & there
are worse blueprints for a home,
like what my grandfather taught
my uncle. we think we know
people until we see the way
they eat a banana, totally unlike
how we peel and devour the fruit,
only instead of eating a banana
it's something way bigger,
like loving another person.

Post by Vibhav Nandagiri, Class of 2025