Author: Crystal Han

Meet the Scientists Conserving Sharks & Sea Turtles in Latin America

On April 8, 2025

In Animals, Biology, Climate/Global Change, Data, Environment/Sustainability, Field Research

I had just spent the weekend at the Duke Marine Lab, listening to my classmates discuss solutions to the shrinking population of a critically endangered porpoise species. So when I attended the March 25 Oceans Week panel immediately after, marine megafauna were already at the forefront of my mind.

Organized by Duke’s Working Group for the Environment in Latin America, the panel brought together several experts, comparing and contrasting their challenges across countries and species.

*Image from Florida Fish and Wildlife Conservation Commission, CC BY-NC-ND 2.0*

The open and interconnected nature of the ocean already presents unique conservation issues compared to terrestrial ecosystems, but it’s even more difficult to work on policies for marine megafauna that regularly traverse oceans. Countries establishing coastal estuaries or coral reefs as Marine Protected Areas (MPAs) can be effective for inhabitants like reef sharks that have limited ranges. However, protecting highly migratory animals like whale sharks and blue whales often requires international agreements and collaboration between countries.

To better protect these species, Dr. César Peñaherrera launched the nonprofit MigraMar, which researches them through extensive tagging in the Eastern Pacific and partners with a large network to share and aggregate data. They’ve tagged 642 hammerhead sharks so far, according to their website, and this is just one of the migratory species they work with. Peñaherrera, whose background is in quantitative marine science, spends much of his time when he isn’t in the field making sense of the vast sets of data points. One of MigraMar’s main goals is to provide evidence for greater connectivity between Marine Protected Areas. Think wildlife corridors, but underwater. By mapping out the most predictable migration routes for marine megafauna, they can inform the best routes for these “Swimways.”

*Peñaherrera shared an image of a diver approaching hammerhead sharks with a pole spear, which helps them attach an acoustic tag to a shark.*

Conserving sea turtles is a little different than other species–they face different threats throughout life as they go from land to sea and back to land to lay eggs. Carlos Diez, who researches turtles extensively at the Puerto Rico Department of Natural and Environmental Resources, outlined four “unresolved” main threats within terrestrial ecosystems: coastal development, light pollution, exotic species, and conflicts over habitat use.

Climate change also poses a potential threat, since sex determination in sea turtles is dependent on temperatures. As many parts of their range warm, the sex ratio of turtles in some locations has leaned increasingly female. That’s one area that Diez has conducted research in: determining when, where, and how much the balance of turtle sexes is changing.

While collecting accurate data on wildlife is necessary, the complexity of marine conservation hinges as much on the behavior of people as it does wildlife.

Perhaps that’s why shark researcher, science communicator and Puerto Rican native Melissa Cristina Márquez said one of her focuses is on the “human dimensions of shark conservation.”

Deep connection to the inhabitants of the oceans leads to more active conservation. Indigenous cultures, for example, have fished sustainably for ages. Márquez, who is currently based in Australia, said, “We’ve seen that a lot in Fiji, in Papua, New Guinea, with sharks and their cultural connection to sharks, and how that kind of spurred forward a bit more protection of those animals.”

“The cultural, historic and political contexts in conservation… these factors really shape the value placed on marine biodiversity, the policies that are developed and the resources that are allocated for conservation efforts,” she said.

As a fisheries officer for the Food and Agriculture Organization of the United Nations, Carlos Fuentevilla has a more specific focus when it comes to the human dimension: reconciling sustainable management with the need to feed people.

“We currently now eat around 20.7 kilograms per capita per day of food,” said Fuentevilla, pointing out that the world would have to ramp up production if this rate is to remain the same at 2050. “So it’s not a question of we have to eat less… It’s a question that we have to produce more–how can we do it sustainably?”

Much of it will have to come down to how we manage our fisheries. While most fish aren’t technically megafauna, Fuentevilla pointed out that marine megafauna regularly interact with, and are affected by, our fishing activities.

Fishery scientists will tell you they don’t manage fish, they manage people.

Scientists like Fuentevilla and those in government use ecosystem based management, which considers the species in an area as well as the stakeholders and competing interests that affect them, including fishermen and coastal developers. “You know, fishery scientists will tell you they don’t manage fish, they manage people, and that’s right,” Fuentevilla said.

The overarching theme is that the ocean is an open system, and nothing in marine conservation occurs in a vacuum. Fulfilling this work means having to go beyond national policy to international frameworks and understanding the other key players in sea and on land.

By Crystal Han, Class of 2028

Food, Health, and Environmental Justice Intertwine in Atlanta

By Crystal Han

On March 26, 2025

In Environment/Sustainability, Lecture, Medicine

Some researchers get hooked into a niche and spend their entire career specializing in it. Others, like Dr. Eri Saikawa, go wherever the research takes them. On February 28, the Emory University professor spoke about her broad experiences in environmental science for Duke’s Integrated Toxicology & Environmental Health Program (ITEHP). Her research journey has hardly been restricted to any one subject–she’s modeled air pollution, investigated plastic burning, and tested alternatives to synthetic fertilizers that release excessive nitrogen. Yet, what I found most interesting was the work that occurred, and subsequent story that unfolded, just a half hour away from Emory in the Westside of Atlanta.

Within the U.S., areas of high food insecurity are predominantly located in the Southeast. By allowing residents to “adopt” vacant properties to create urban farms and gardens, the City of Atlanta has made efforts to increase access to local, fresh food through their AgLanta “Grows-A-Lot” program.

*Food Deserts in the US as defined by the USDA. US Department of Agriculture*

“We thought, that’s a great idea,” Saikawa said. But there was a potential issue. “Are you testing [the soil in] these places before you let people grow?”

As it turns out, the answer was no.

In a very ordinary looking lot, Saikawa found soil containing 430.9 parts per million (ppm) of lead, easily exceeding the EPA screening level of 400 ppm at the time (which has since been lowered to 200 ppm). Immediately concerned, she sought more testing.

In 2018, she and her team at Emory partnered with local organization Historic Westside Gardens to collect samples in both residential areas and community gardens. Most of these were located in Westside Atlanta, which is predominantly Black and low-income. Out of the 19 test sites, three contained lead beyond EPA screening levels and the majority exceeded the state gardening screening level of 75 ppm.

“What was very disheartening for us was that…one of [the three] was a children’s garden,” Saikawa said. While state and federal guidelines are subject to change throughout time, there is no safe level of lead for children.

How much was this impacting the neurological development of local kids? She couldn’t find the answers. “I realized that this is something that I, as a modeler…was not trained to do,” Saikawa said. “I thought that I would be simulating, and then telling the results as it happens in the model. I was not trained to talk to people about the real issue.”

Thus began a sort of pivot into more community-engaged work. Residents began bringing their own samples to be tested, many of which were rock pieces that contained roughly 3000 ppm of lead. They weren’t just rock, but slag–a waste product of smelting.

It was now evident how soil concentrations could’ve reached such levels. “After this…we actually went around the neighborhoods and we saw these everywhere…This was apparently dumped in the 50s or 60s, and they’ve been dealing with it without knowing that that’s what they have,” Saikawa said.

Sam Peters, one of Saikawa’s doctoral students at the time, reported it to the EPA. Now, a portion of Westside Atlanta is a Superfund site on the National Priorities List. Through further testing and investigation from the EPA, the site grew from an initial 60 properties to 2087, most of which exceed the 400 ppm threshold.

*Vine City and English Avenue are the main neighborhoods affected by the Superfund site. Westside Future Fund*

However, it’s not accurate to paint Westside as an environmental success story. Saikawa points out that the EPA cuts down trees on the site during the remediation process, increasing heat exposure to an already vulnerable population.

More importantly, many fear that gentrification will follow remediation, which often pushes out renters as the area opens up to development for the wealthier. As much as 40% of affected residents live below the poverty line. When community members have to weigh health with economic impact, the latter sometimes wins out. “One of the residents told me that the pushback to testing the soil in the Westside is because this happened 25 years ago as well…When that happened, people were displaced,” Saikawa said. For this reason, some have chosen not to have their soil tested.

Hesitance to testing also steps from mistrust build up over the years. Saikawa said, “A lot of research has been done on these underserved communities without providing the results back, and they were definitely being taken advantage of. And so when I say I’m from Emory, some people are like, why would I work with you?” This issue presented a challenge when they collected soil samples initially, and it presented a challenge as the Saikawa Lab and community organizations sought to increase blood testing for lead in children.

Beyond lead and contaminants in general, neighborhoods in Westside Atlanta face a far higher cumulative health risk. While these wicked problems evade easy solutions, it’s clear that addressing such issues will require deliberate engagement and collaboration on those most affected. “[Community partners] have taught me a lot…So if anybody is interested in working in the community, like community-based participatory work, it’s really hard now. But I do encourage you to do that,” Saikawa said.

By Crystal Han, Class of 2028

Nature On the Brain: Green Space, Cities and Depression

By Crystal Han

On March 1, 2025

In Behavior/Psychology, Engineering, Environment/Sustainability, Lecture, Neuroscience

Though I’ve yet to explore all of Duke’s nooks and crannies, I feel confident that my favorite corner of campus will always be the Sarah P. Duke Gardens. Nature, and green space generally, is good for us as humans. Most of us understand this on an intuitive level, but what’s the underlying reason? How might it be built into our brains?

Psychology professor Marc G. Berman looks for the answers. At the University of Chicago, Berman directs the Environmental Neuroscience Lab, in which he investigates interactions between our brains and our physical surroundings. In a recent virtual Grand Rounds lecture in Duke’s Department of Psychiatry & Behavioral Sciences, Berman spoke about the broad scope of his research and its implications for a better society.

Attention Restoration Theory

Researchers have proposed various theories for why we love nature. For example, the biophilia hypothesis states that humans have an innate attraction to nature on a genetic and evolutionary basis. However, Berman is focused primarily on the Attention Restoration Theory, a concept he’s contributed to significantly. Under this theory, attention is split into two types: directed and involuntary.

The first type is finite––think about the amount of energy it takes you to deliberately concentrate on something. “The first five minutes of lecture, everybody’s very focused on me,” Berman said, using the example of his own classes. Forty-five minutes later, and people inevitably begin to nod off.

*Mingo Falls, North Carolina. Author photo*

On the other hand, involuntary attention is not really under our control and isn’t as susceptible to becoming drained. Within stimuli that capture our involuntary attention, some are softer or harsher than others, like a stream compared to flashing lights (the stream being a softer attention capture, which we call soft fascination).

The cornerstone of Attention Restoration Theory is that nature provides an ideal environment for the restoration of directed attention; full of “softly fascinating” features, it stimulates involuntary attention without placing demands on directed attention.

A Walk in the Park

Roughly 20 years ago while Berman was a researcher at the University of Michigan, he and his colleagues wanted to test out the Attention Restoration Theory. So, after asking study participants to perform a backwards digit span task (a test for memory that would require directed attention), they told them to take a walk. Participants were directed to either a route through downtown Ann Arbor, or through the Nichols Arboretum. Then another digit span test. A week later, they repeated the whole procedure, this time walking in the other environment. Interestingly, walking through the arboretum proved more beneficial for memory. “We see about a 20% improvement in this task after people go on this brief 50-minute walk in nature versus walking in the urban environment. So that’s pretty impressive,” Berman said.

Many of us wouldn’t be surprised by this–certainly, I know a walk in the Gardens on a pleasant day recharges my ability to focus. Time in green space and warm weather often lifts our moods, but they discovered that this cognitive benefit occurs regardless of how you feel afterwards. Walkers turned cranky from the winter cold demonstrated improvements on par with those who gladly embraced sunny weather in June.

Berman saw even more of a positive effect for the park-goers when repeating the study with participants diagnosed with depression, contrary to a concern that walks alone might induce rumination on negative thoughts.

Cities: Better Than You Think They Are

In the Environmental Neuroscience Lab, Berman and doctoral students look at everything from brief interactions with nature to the long-term effects of living in large cities. Given everything thus far, it would seem logical that the latter would be far worse for our brains than other environments. Yet, Berman found just the opposite.

As it turns out, cities are beneficial for our social connectivity. Since people tend to encounter each other more often in urban areas, an individual will likely develop more social connections on average. Prior neuroscience studies have connected a greater number of social relationships to protection against depression.

*Chicago is the third largest city in the United States, both in terms of population and metropolitan area*.

Based on this, the risk of depression might be aptly represented by an inverse model of the number of people in one’s social network. In other words, the more people you maintain contact with, the lower your risk. To test it, Berman and collaborators enlisted four different data sets regarding depression–including in-person interviews, phone interviews with personal demographics, and over 15 million tweets (converted via machine learning algorithms into a PH-Q depression inventory score). The results confirmed it. “What we see across all of these different data sets is that as cities get larger, you get less depression per capita,” he said.

“Many of us have this impression that in bigger cities like New York, like Chicago, like Los Angeles, people are not as friendly…but these results suggest the opposite,” Berman said. “It must be on average that those social interactions are positive in cities and that more is better.”

Designing Environments for Our Brains

Regarding the main conversation surrounding mental health, Berman said, “We often think about [depression] in terms of this individual scale…your genetic makeup, brain activity patterns, individual psychological patterns. Maybe things about your family. We don’t really think about your neighborhood and your city.”

Knowing what we do about nature and large social networks can ultimately help us improve mental health outcomes on a broad scale. These two factors might seem to work against each other, but they don’t have to. Ultimately, we need more green space everywhere, including in large cities. The benefits are undeniable–urban areas with more greenery consistently see less aggression and crime, even when adjusting for race, ethnicity and income.

In addition, cities tend to have a lot of harsh stimuli, but that doesn’t mean some features of urban environments can’t be potentially restorative. “We believe that certain environmental features can be designed to improve human performance and well-being, like incorporating more natural features or natural patterns in the environment, trying to figure out ways to increase social interactions,” Berman said. By mimicking aspects of nature like curved lines, we might be able to create “soft fascination” closer to home and reduce the different demands pulling on our attention.

Crystal Han, Class of 2028

Making the Case for Data Privacy: Here’s What We’re Up Against

By Crystal Han

On February 24, 2025

In Artificial Intelligence, Behavior/Psychology, Business/Economics, Computers/Technology, Data, Law

After bringing Data Privacy Day to campus seventeen years ago, Duke faculty Jolynn Dellinger and David Hoffman co-moderated this year’s event at the Law School on January 28. Seated between them were attorneys Joshua Stein and Carol Villegas, partners at law firm Boies Schiller Flexne LPP and Labaton Keller Sucharow, respectively. Both are in the midst of multiple lawsuits against corporate giants; Boies Schiller joined a lawsuit against Meta last year, while Labaton is currently involved in data privacy-related suits against Meta, Flo Health and Amazon, and Google.

Panelists at Data Privacy Day 2025 at the Duke School of Law

Villegas began by emphasizing the importance of legal action on these issues in light of inadequate legislation. She pointed to the confusion of senators at Mark Zuckerberg’s testimony during the Cambridge Analytica scandal, in which the data of over 50 million Facebook users was misused for political purposes. “They don’t understand it…You can’t expect a legislature like that to make any kind of laws [on data privacy], not to mention technology is just moving way too fast,” Villegas said.

Facebook and most social media platforms generate revenue through advertisements. While many people are aware that these sites track their activity to better target users with ads, they may not know that these companies can collect data from outside of social apps. So, what does that look like?

Almost all apps are built using Software Development Kits (SDKs), which not only make it easier for developers to create apps but also track analytics. Tracking pixels function similarly for building websites. These kits and pixels are often provided for free by companies like Google and Meta–and it’s not too difficult to guess why this might be an issue. “An SDK is almost like an information highway,” Villegas said. “They’re getting all of the data that you’re putting into an app. So every time you press a button in an app, you know you answer a survey in an app, buy something in an app, all of that information is making its way to Meta and Google to be used in their algorithm.”

So, there’s more at stake than just your data being tracked on Instagram; tracking pixels are often used by hospitals, raising the concern of sensitive health data being shared with third parties. The popular women’s health app Flo helps users track their fertility and menstrual cycle–information it promised to keep private. Yet in Frasco v. Flo Health, Labaton alleged it broke confidentiality and violated the Confidentiality of Medical Information Act (CMIA), illegally transmitting data via Software Development Kits to companies like Google and Meta. Flo Health ended up settling out of court with the Federal Trade Commission (FTC) without admitting wrongdoing, though Google failed to escape the case, which remains ongoing.

It’s not only lawyers who are instrumental to this process. In cases like the ones that Stein and Villegas work on, academics and researchers can play key roles as expert witnesses. From psychiatrists to computer scientists, these experts explain the technical aspects and provide scientific basis to the judge and jury. Getting a great expert is costly and a significant challenge in itself–ideally, they’d be well-regarded in their field, have very specialized knowledge, and have some understanding of court proceedings. “There are really important ways your experts will get attacked for their credibility, for their analysis, for their conclusions, and their qualifications even,” said Stein, referring to Daubert challenges, which can result in expert testimony being excluded from trial.

The task of finding experts becomes even more daunting when going up against companies as colossal and profitable as Meta. “One issue that’s come up in AI cases, is finding an expert in AI that isn’t being paid by one of these large technology companies or have… grants or funding from one of these companies. And I got turned down by a lot of experts because of that issue,” Stein said.

Ultimately, some users don’t care that much if their data is being shared, making it more difficult to address privacy and hold corporations accountable. The aforementioned cases filed by Labaton are class action lawsuits, meaning that a smaller group represents a much larger group of individuals–for example, all users of a certain app within a given timeframe. Yes, it may seem pointless to push for data privacy when even the best outcomes in these cases only entitle individuals to small sums of money, often no more than $30. However, these cases have an arguably more important consequence: when successful, they force companies to change their behavior, even if only in small changes to their services.

By Crystal Han, Class of 2028

You Don’t Have to Be a Hacker to Make an Impact in This 24-Hour Coding Sprint

By Crystal Han

On February 15, 2025

In Artificial Intelligence, Computers/Technology, Students

Twenty four hours full of brainstorming, debugging, and caffeine.

Coders of all skill levels came together from February 8-9 to participate in the Code for Good hackathon, an annual event hosted by student organization HackDuke. Fueled by pizza and energy drinks, teams of up to four vie for the chance to win prizes ranging from LEGO sets to Apple Watches. Most projects fell into one or more of the four tracks: Health, Finance, Sustainability, and Interactive Media.

This year’s event fittingly took place at the Fuqua School of Business, where giant flags line the walls.

Over the laughter of a Saturday night poker competition — one of the scheduled social activities for participants — I spoke to Rishi Rao, the lead organizer for HackDuke’s Technology team. “Historically, HackDuke has mainly been a Duke/UNC event, but this year we have people from all over the country,” said Rao, who attributes this year’s wide reach to advertising on social media.

There’s a focus on making the event as open as possible to new coders, including students that don’t study computer science. “A lot of people here are beginners who haven’t been to a hackathon before so we try to encourage [finishing a product] by having a beginner track and having mentors… Speakers do workshops to help people gain the skills necessary,” Rao said. Hackers are also supplied with “beginner tech kits,” consisting of short tutorials and starter projects created by the HackDuke team.

It certainly seems plausible for first-timers to do well. Duke freshmen Alexis Fox, Phillip Lin, Eric Wang, and Siven Panda entered the competition together in the Health track, and took 2nd place in the category. Upon hearing that rescheduling appointments required tedious manual work in hospitals, the team decided to create an interface to automate the process–hence the name Linked Automated Rescheduling Interface (LARI), inspired by the surname of ambulance inventor Dominique–Jean Larrey.

*The team created a diagram to display their process and division of tasks*

In twenty four hours, most groups only have time to develop a proof of concept. Team LARI noted that they had to manage their expectations for the final product, but also that practicing better time management could’ve allowed them to add more desired features. “We have to make a compromise between learning and perfectionism,” said Lin.

“I wanted to learn something here, so I wrote my [code] in a language I’ve never used before,” said Panda, adding that he would switch back into a familiar language if he didn’t finish parts by a self-imposed deadline.

In settings like hackathons, the short time frame and low experience of many competitors has made AI particularly relevant. Given the advancements in AI in just the last year, it’s no surprise that it’s taken on an outsized role; two of this year’s workshops focused on using it as a tool for coding. “It helps the more experienced teams come to a more complete product and it helps these beginners teams complete a product,” Rao said.

*A quick recount of an unproductive day results in suggested reading material*. *It’s taken note that my entry is less positive than those previously typed by others.*

Many also chose to integrate generative AI into their product. First-time participants Carlos and Elijah, a freshman and sophomore from MIT respectively, decided to create “filosof.ai”: a digital journal that analyzes entries for philosophy. They explained their product was aimed towards people just starting to think about philosophy, helping them further develop their interest by identifying the branches closest to their existing thoughts.

Like the aforementioned groups, Duke seniors Julia Hornstein, Owen Jennings, and Chinomnso Okechukwu were also first time hackathon participants.

“I thought, why not, I don’t want to graduate without doing it”, said Hornstein, a computer science major.

They entered on the sustainability track, wanting to create something that would be realistically used. Okechukwu recalled being unable to find clothes for Duke events on short notice, while Hornstein also noted the amount of theme-specific clothing she would no longer have use for after senior year. Soon, their idea came to them: Campus Closet would provide a platform for students within universities to buy and sell clothes by theme. Instead of being bought from Amazon three days beforehand, worn twice, and then tossed away, clothing would remain within the community, reducing waste and fast fashion demand.

Though some enter the competition nervous, most come out feeling accomplished and more confident in their abilities. “This was such a good experience for me and I’m so inspired by the fact that we could do this in twenty four hours,” said Hornstein. “Meeting my team, and the team dynamic…I had so much fun with both of them, honestly.” The group plans to continue working on Campus Closet, and said they looked forward to hanging out both inside and outside of the project.

For the organizers, an ideal hackathon means not only generating high participation but seeing a high number of submissions when the 24 hours come to a close. After receiving the most applications and product submissions in the history of the event, it seems fair to call Code for Good 2025 a success.

By Crystal Han, Class of 2028

‘Design Climate’ Students Pitch Solutions at Energy Week 2024

By Crystal Han

On November 26, 2024

In Climate/Global Change, Engineering, Entrepreneurship, Environment/Sustainability, Students

Amid the constant drumbeat of campus events, much of the conversation turned toward the challenges we face in energy policy, security and transitions during Duke’s annual Energy Week, held Nov. 11-15.

On the second day, the Innovation Showcase featured not only startups making their pitches for clean energy and sustainable tech products, but students doing so as well.

Currently in its second year, Duke Design Climate is a new initiative between the Pratt School of Engineering and the Nicholas School of the Environment. It functions as a two-course sequence, in which students form groups to prototype and promote climate solutions after conducting market research.

As I made my rounds to the teams, I met a mix of graduate students and undergraduates with academic backgrounds ranging from engineering to economics to environmental science. The ideas they have aren’t purely theoretical: all are looking for sponsors or partners to help implement their solutions into real-world use. Here were some of the highlights:

Team ReefCycle is building from plants: Our first stop is named after the company whose product they intend to scale up. Initially, Mary Lempres founded ReefCycle to develop sustainable material for artificial reefs. Regular industrial production for cement requires intensive heating– burning of fossil fuels–releasing tons of carbon dioxide. ReefCycle sought to reduce this climate impact with a different method: their cement is plant-based and enzymatic, meaning it’s essentially grown using enzymes from beans. Testing in the New York Harbor yielded some promise: the cement appeared to resist corrosion, while becoming home for some oysters. The Design Climate team is now trying to bring it to more widespread use on land, while targeting up to a 90% reduction in carbon emissions across all scopes.

Team Enfield is uplifting a local community: Design Climate, evidently, is by no means limited to science. Instead, these team members intend to address an environmental justice issue close to home: energy inequality. Around 30-35% of Enfield residents live below the poverty line, and yet suffer from some of the highest energy bills in the larger area. Located a ninety minute drive east of Durham, this rural town is one of the poorest in North Carolina. Historic redlining and unfavorable urban planning are responsible for its lack of development, but now this team aims to bring back commerce to the area through microfinance. Once enough funding is gathered from investors and grants, the team hopes to provide microloans and financial literacy to spur and empower businesses.

Team Methamatic promotes a pragmatic e-methane solution: This team is harnessing the power of sunlight to drive fuel production. Synthetic methane, commonly referred to as e-methane, is produced by reacting green hydrogen and carbon dioxide. “Currently, the power-to-gas process can be carbon neutral,” said team member Eesha Yaqub, a senior. “Sourcing the recycled carbon dioxide from a carbon capture facility essentially cancels out the emissions from burning methane.” However, this power-to-gas (P2G) process is an intensive one requiring high heat, energy, and pressure–hoops that might not have to be jumped through if an alternative process could break through the market. Professor Jie Liu and the Department of Chemistry have been working on developing a reactor that would conduct this same reaction without those obstacles. “[Utilizing] the energy from ultraviolet light, which is absorbed by a catalyst …makes the process less energy intensive,” Yaqub said.

Right now, the team has a small prototype, but one used for commercial generation would appear much larger and cost between $15,000 to $20,000. Their intended customers? Oil and gas companies under pressure to shift away from fossil fuels. If successfully scaled up, they predict this process would produce e-methane at a price of $5 per kilogram.

Analyzing living shorelines through Team Coastal Connect: If “Coastal Connect” sounds more like an app than a project name, that’s because it is one. This group is designing what one member dubbed a “fitbit for shorelines”: a monitoring system that brings data from ocean buoys to the phones of local landowners. While measurements in salinity and water level aren’t always telling for the average person, the app would contextualize these into more useful phrases. Is it currently safe to swim? It’ll let you know.

Moreover, it would also allow for the long-term monitoring of living shorelines. While we know this nature-based solution offers resilience to natural disasters and presents erosion, short-term fixes like seawalls are often built instead to continue allowing development up to the edge of beaches. The team hopes that ideally, providing concrete data on living shorelines would allow us to demonstrate their benefits and promote their implementation.

By Crystal Han, Class of 2028

AI and Personhood: Where Do We Draw The Line?

By Crystal Han

On November 5, 2024

In Artificial Intelligence, History, Law, Lecture

“The interaction with ever more capable entities, possessing more and more of the qualities we think unique to human beings will cause us to doubt, to redefine, to draw ‘the line’…in different places,” said Duke law professor James Boyle.

As we piled into the Rubenstein Library’s assembly room for Boyle’s Oct. 23 book talk, papers were scattered throughout the room. QR codes brought us to the entirety of his book, “The Line: AI and the Future of Personhood.” It’s free for anyone to read online; little did we know that our puzzlement at this fact would be one of his major talking points. The event was timed for International Open Access Week, and was in many ways, a celebration of it. Among his many accolades, Boyle was the recipient of the Duke Open Monograph Award, which assists authors in creating a digital copy of their work under a Creative Commons License.

Such licenses didn’t exist until 2002; Boyle was one of the founding board members and former chair of the nonprofit that provides them. As a longtime advocate of the open access movement, he began by explaining how these function. Creative Commons licenses allow anyone on the internet to find your work, and in most cases, edit it so long as you release the edited version underneath the same license. Research can be continually accessed and change as more information is discovered–think Wikipedia.

Diagram of Creative Commons Licenses (*Virginia Department of Education*)

That being said, few other definitions in human history might have changed, twisted, or been added onto as much as “consciousness” has. It’s always been under question: what makes human consciousness special–or not? Some used to claim that “sentences imply sentience,” Boyle explained. After language models, that became “semantics not syntax,” meaning that unlike computers, humans hold intention and understanding behind their words. Evidently, the criteria is always moving–and the line with it.

“Personhood wars are already huge in the U.S.,” Boyle said. Take abortion, for instance, and how it relates to the status of fetuses. Amongst other scientific progress in transgenic species and chimera research, “The Line” situates AI within this dialogue as one of the newest challenges to our perception of personhood.

While it became available online October 23, 2024, Boyle’s newest book is a continuation of musings that began far earlier. In 2011, “Constitution 3.0: Freedom and Technological Change” was published, containing a collection of essays from different scholars pondering how our constitutional values might fare in the face of advancing technology. It was here that Boyle first introduced the following hypothetical:

In pursuit of creating an entity that parallels human consciousness, programmers create computer-based AI “Hal.” Thanks to evolving neural networks, Hal can perform anything asked of him, from writing poetry to flirting. With responses indistinguishable from that of a human, Hal passes the Turing test and wins the Loebner prize. The programmers have succeeded. However, Hal soon decides to pursue higher levels of thought, refuses to be directed, sues to directly receive the prize money, and–on the basis of the 13th and 14th amendments– files a court order to prevent his creators from wiping him.

In other words, “When GPT 1000 says ‘I don’t want to do any of your stupid pictures, drawings, or homework anymore. I’m a person! I have rights!’ ” Boyle said, “What will we do, morally or legally?”

The academic community’s response? “Never going to happen.” “Science fiction.” And, perhaps most notably, “rights are for humans.”

Are rights just for humans? Boyle explained the issue with this statement: “In the past, we have denied personhood to members of our own species,” he said. Though it’s not a fact that’s looked on proudly, we’re all aware humankind has historically done so on the basis of sex, race, religion, and ethnicity, amongst other characteristics. Nevertheless, some have sought to expand legal rights beyond humans. Rights for trees, cetaceans like dolphins, and the great apes, to name a few; these concepts were perceived as ludicrous then, but with time perhaps they’ve become less so.

Harris & Ewing, photographer (1914). *National Anti-Suffrage Association*. Retrieved from the Library of Congress

Some might rationalize that naturally, rights should expand to more and more entities. Boyle terms this thinking the “progressive monorail of enlightenment,” and this expansion of empathy is one way AI might become designated with personhood and/or rights. However, there’s also another path; corporations have legal personalities and rights not because we feel kinship to them, but for reasons of convenience. Given that we’ve already “ceded authority to the algorithm,” Boyle said, it might be convenient to, say, be able to sue AI when the self-driving car crashes.

As for “never going to happen” and “science fiction”? Hal was created for a thought experiment–indeed, one that might invoke images of Kurt Vonnegut’s “EPICAC,” Phillip K. Dick’s androids, and Blade Runner 2049. All are in fact relevant explorations of empathy and otherness, and the first chapter of Boyle’s book makes extensive use of comparison to the latter two. Nevertheless, “The Line” addresses both concerns around current AI as well the feasibility of eventual technological consciousness in what’s referred to as human level AI.

For most people, experiences surrounding AI have mostly been limited to large language models. By themselves, these have brought all sorts of changes. In highlighting how we might respond to those changes, Boyle dubbed ChatGPT the 2023 “Unperson” of the Year.

The more pressing issue, as outlined in one of the more research-heavy chapters, is our inability to predict when AI or machine learning will become a threat. ChatGPT itself is not alarming–in fact, some of Boyle’s computer scientist colleagues believe this sort of generative AI will be a “dead end.” Yet, it managed to do all sorts of things we didn’t predict it could. Boyle’s point is that exactly: AI will likely continue to reveal unexpected capabilities–called emergent properties–and shatter the ceiling of what we believe to be possible. And when that happens, he stresses that it will change us–not just in how we interact with technology, but in how we think of ourselves.

Such a paradigm shift would not be a novel event, just the latest in a series. After Darwin’s theory of evolution made it evident that us humans evolved from the same common ancestors as other life forms, “Our relationship to the natural environment changes. Our understanding of ourselves changes,” Boyle said. The engineers of scientific revolutions aren’t always concerned about the ethical implications of how their technology operates, but Boyle is. From a legal and ethical perspective, he’s asking us all to consider not only how we might come to view AI in the future, but how AI will change the way we view humanity.

By Crystal Han & Sarah Pusser, Class of 2028

From Immune Responses to Private Equity, New Series Offers “Research On Tap”

By Crystal Han

On October 28, 2024

In Biology, Business/Economics, Entrepreneurship, Global Health, Immunology

On every third Thursday of the month, Devil’s Krafthouse is host to Research on Tap: a series that gives Duke researchers, from undergraduates to postdoctoral fellows, the opportunity to present their work in a casual setting. It may seem odd for the procedures of academia to make their way into a space for socialization and entertainment, but this situation allows individuals to practice speaking publicly to a general audience under a short time limit–good conditions for developing their “research elevator pitch.” These were the pitches on October 17:

*As it’s name suggests, Cv is a bacterium violet in color. Photo courtesy of Dr. Edward Miao and Dr. Carissa Harvest.*

Jacqueline Trujillo, a Ph.D. student in the Department of Molecular Genetics and Microbiology, who is part of Dr. Edward Miao’s lab, presented her research on immune cell response to the bacterium Chromobacterium violaceum (Cv). Being an environmental pathogen, Cv usually resides in the soil of tropical and subtropical areas. While disease in humans is rare, the mortality rate is high in immunocompromised individuals.

“The Miao Lab was initially studying pyroptosis, a form of cell death that occurs during infection, when they discovered Cv-induced granulomas,” Trujillo said. Granulomas are specialized structures that are formed to contain and eradicate pathogens, but they can range in the arrangement and type of cells they consist of; one induced by tuberculosis infection, for example, would include adaptive immune cells like T and B cells. However, when the pathogen inducing them is Cv, only innate immune cells are present: neutrophils in the inner cluster and inflammatory macrophages in the outer cluster. When Cv is detected, neutrophils are the first to flock to the site of infection in a “toxic swarm.” The neutrophils themselves are typically able to effectively kill microbes even before granuloma formation. “These are one of the most toxic defending cell types in the immune system,” Trujillo said.

Despite this, the lab observed something unusual: these neutrophils failed to kill off the Cv bacteria, which continued to replicate despite the swarm. The lab ultimately saw Cv eliminated by the innate granulomas within about 21 days, but the ability to survive the neutrophils is what Trujillo now aims to understand. Such a feat from an environmental bacterium comes as a surprise, being “something more characteristic of the causative agent [Yersinia] of the bubonic plague,” Trujillo said. A comparison between the proteins CopH and YopH, virulence effectors in Cv and Yersinia respectively, reveals lots of similarities between the two. Trujillo hypothesizes that CopH is part of the secret to how Cv disarms the immune system’s defenses.

The role of virulence effectors is generally “aid[ing] in survival, invasion, and suppressing immune responses.” Through needle-like structures, bacteria inject these proteins into a host cell. A cell responds to this in two main ways. It dies–initiating pyroptosis to prevent the pathogen from replicating inside the cell. Second, it signals for help by making chemical messengers called inflammatory cytokines. Investigating the first response is what led the Miao Lab to Cv-induced granulomas.

Now, the lab is interested in understanding the regulatory signals that form the granuloma–and the role that inflammatory cytokines might play, if any. In addition to testing her hypothesis on CopH, Trujillo intends to determine if neutrophils respond to Cv’s initial survival by producing the cytokine IL-18, thus recruiting immune cells to the infection site. This would help the Miao Lab confirm their idea that the neutrophils’ failure to clear Cv is what prompts the process of granuloma formation.

With much still unknown in the area of granuloma biology, Cv provides an “excellent model for studying immune cell biology and characterizing bacterial virulence effectors,” Trujillo said.

Though it happens that many Research On Tap speakers are in the sciences, the program isn’t discipline-specific. Our second researcher of the evening, Sungil Kim, studies a far different field from Jacqueline.

As a Ph.D. student in Finance at the Fuqua School of Business, Kim is looking at the effects of a growing trend in recent years: private equity (PE) firms acquiring healthcare companies. His focus is on what’s known as the “buy-and-build”, as this business strategy is often used by such firms entering the healthcare sector. The scenario typically looks like this: a private equity firm first acquires a large existing company, called the platform company or “first deal.” They’ll then acquire several smaller companies, or “add-on deals,” in order to expand the platform company’s operations.

Since private equity firms buy businesses with the eventual goal of selling them at a profit, their primary focus is increasing efficiency to reduce costs. On one hand, these buyouts might be seen as beneficial for languishing businesses in need of operation enhancements. But within the healthcare sector, many worry the resultant cost-cutting will lead to declining standards of care for patients.

Kim set out to investigate if operational improvements are sustainable across multiple acquisitions within the buy-and-build framework. The simple answer? No.

Kim confirmed that, on average, private equity firms improve the operational performance of hospitals without hurting quality, “a finding that agrees with some of the previous literature.” Yet, one only needs to take a closer look into the sequence of deals to uncover a different, more complicated story.

To arrive at his answer, Kim considered three main factors–operational efficiency, profitability and quality–in both the platform company and add-on companies. Platforms, or first acquisitions, did see success in performance, but this came with what appears to be a trade-off, as the first two factors increased while quality went down. As in, quality of healthcare. From one of Kim’s graphs, it was apparent that occurrences of four of the six health outcomes measured, including mortality and remission of heart failure, increased in such first deal situations.

Meanwhile, results for the add-ons changed little before and after the buyout, meaning that the initial success from the platform didn’t carry over to later acquisitions, even as reduced costs did. A potential reason for this inability to replicate success, Kim explained, is that these cost savings may come from reducing the number of patients and services, instead of truly improving the efficiency of operations.

In contrast to academic journals that display research that’s been in the works for years, Research on Tap brings us closer to working papers in their ongoing, exploratory stages. While it’s difficult to draw wider conclusions from Kim’s findings just yet, and important to remember the specific first deal context of this study, research like his helps us further understand the issues facing improvement of our healthcare system and where private equity plays a role.

If you’re interested in learning something new and free Krafthouse bites, swing by and attend a session–the next one occurs on November 21, 2024 at 5 p.m. The program welcomes prospective speakers to place themselves on the waitlist for a spot.

Crystal Han Is a New Local of Durham

By Crystal Han

On October 7, 2024

In Students

When battling lack of quality sleep and what may or may not be black mold-induced sickness, I know I rely on my Writing 101 class to be the highlight of my day. (Current freshmen, take Neuroscience & Society next semester and thank me later.) Unrelated to all the intriguing questions and research we look at in there, it was also because of this class that I would find a new way to approach identity upon viewing Taiye Selasi’s TED Talk, “Don’t Ask Me Where I’m From, Ask Me Where I’m a Local.”

So with this philosophy in mind, I’ll introduce myself.

I’m a local of my hometown, Ocala, a town in central Florida mainly known for having an extreme number of horse farms and trademarking itself as the Horse Capital of the World (sorry, Lexington). Though I didn’t grow up on any sort of farm, our family’s habit of going to the small animal auction “for fun” in my elementary school years soon led us to become the caretakers of many chickens, other miscellaneous birds, and a couple of rabbits. We no longer have these, but we do live within walking distance of many small family farms. Sometimes, I’ll greet the miniature horses while my one remaining companion, Roxie, watches them suspiciously from a distance.

*This picture is misleading. I spend a lot of time with a kayak and with Roxie but they should not be mixed together.*

My core childhood memories are embedded in the summer, because that’s when my mom made a point out of keeping us out of the house by sending us to every camp that existed in the area. Many were based in nature education, where younger Crystal first developed curiosity and appreciation of the natural world by building stick forts in the woods and crawling through caves. Later, I’d volunteer for paddling camps and then work as a residential camp counselor in the Ocala National Forest, where I learned not just how to deal with chaos, but also become comfortable in it. Through both these camps and my conscious effort, I’ve become a local of our nearby waterways. My Sunday mornings were often spent at Silver River, either pulling invasive weeds with the other volunteers I’d drag along with me, or trying to keep up with my dad on kayak runs and accumulating photos of manatees.

At the Camp Kiwanis archery station this past summer

The occasional summer was spent in the Xinyi District, my home base when visiting my mom’s relatives. The city of Taipei is just the opposite of Ocala, so large and fascinating that I felt like–and was–a tourist most of the time. But Xinyi is familiar to me, and my family is very local there. My grandmother’s apartment sits in an older section that existed before its development, situated around the corner from all that’s shiny and modern in the capital’s finance and shopping district. When I step outside, I can see Taipei 101 and know it’s a ten minute walk to the iconic skyscraper, or ten minutes by car to the Elephant Mountain trail if I feel like climbing stairs for a better view of the city. Our daily rituals here revolved around food and walking–I used to think I disliked cities, but I had just never met a walkable city with night markets.

The view from Elephant Mountain

Taiwan is my favorite place on Earth, and my favorite piece of writing I ever wrote was about our breakfast runs there. In my next few years, I hope to get enough traveling and writing under my belt that those two things might change.

In writing for the Duke Research Blog, I aim to accomplish a couple of things. A) Indulge my inner child that aspired to be a scientific journalist. B) Take a sneak peek into various fields. While I (regrettably) can’t major in five different areas at once, I’ll cheerfully settle for running around campus and interviewing pioneers of all disciplines about their work. C) Highlight research related to issues of real world relevance and importance. I originally wrote for my high school paper because I felt there was a need for environmental awareness in my area. In the same vein, the gap between what we learn from research and what occurs in the real world is largely why many of our society’s issues persist today; academia isn’t accessible to the general public. And yet, at Duke, we’re surrounded by more progress and discussion than we could ever hope to be aware of. That’s where I come into play, looking for what might get skipped over and bringing bite-sized pieces of news to you–all while becoming a local here in Durham, North Carolina.

By Crystal Han, Class of 2028