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Tag: cell biology

What can we learn from watching a fish’s ear take shape? You might be surprised

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Dr. Akankshi Munjal is a developmental biology researcher at Duke University, who studies the development and mutations of inner ear tissue in zebrafish, and how that may be caused by genome disorders. 

Akankshi Munjal, assistant professor of cell biology

From a young age, Munjal has been fascinated by watching things being built and developed. Her grandfather was a civil engineer, and she was inspired by the many blueprints littering his home. Growing up, she wanted to be an architect. 

Though she found inspiration elsewhere, and did not pursue architecture, in a way, her career mirrors this, “I guess I am not an architect, but I still watch embryos being built, so that kept with me – how you shape things.” 

The inspiration of Munjal’s current career came to her in high school. Growing up, she lived in a large city in India, and did not have much exposure to science fields and research. “If you don’t see it around you, it’s not something you see as an option.” 

However, she was able to find inspiration from a few of her instructors, “There were some teachers who were very inspiring in exposing that there is research out there, that you can be at the bench, ask questions, and address them using experiments.” 

She was also involved with a project dealing with bacteria that could process heavy metals in the Yamuna river near Delhi, India, and this helped introduce the idea of research as a potential career path. 

Though most of Munjal’s work has moved toward lab management, the research is what she really loves, “I could spend days in the microscope room, watching development happen.”

The interesting thing about zebrafish, is that their eggs are transparent, and develop outside of the parent organism. This provides an incredible way to observe the development of tissues under a microscope. Zebrafish also share 70% of the DNA of humans, which makes them a great model organism to observe human disorders and how they affect tissue. The ability to witness this development is Munjal’s favorite part of the job,“It’s why I love what I do, we are able to watch these things happen, in the lab.”

When asked what she wished she would’ve learned earlier on, she mentioned the classic comparison of teaching a man to fish, as opposed to giving him a fish. She applies this saying to the process of learning. In her earlier education, there was an emphasis on collecting and memorizing information and facts, rather than learning how to gather knowledge. An emphasis on academic intelligence, as opposed to emotional intelligence. 

Looking back, this presentation and memorization of facts was less helpful, “Some of them are not facts, some of them are interpretations, so if there was more information on collecting knowledge, that would be more helpful.”

Munjal loves to watch things being developed. This not only applies to her research in developmental biology, and her former passion for architecture, but also to her love of collecting knowledge. 

Guest post by Rhynn Alligood, NCSSM class of 2025

Behold: the Cell’s Skeleton in Motion

To many of us, cells are the building blocks of life, akin to bricks or Legos. But to biologist Regan Moore, a former Ph.D. student in Dan Kiehart’s lab at Duke, cells are so much more: they’re busy construction sites, machinery and materials moving about to build and shape the body. And now, new live imaging techniques make it possible to watch some of the nano-scale construction in action.

In time-lapse videos published this month, Moore, Kiehart and colleagues were able to peer inside cells as they filled a hole in the back of a developing fruit fly, a crucial step in the fly’s development into a larva. The process is coordinated with help from a thin mesh of protein fibers just under the cell surface, each one 10,000 times finer than a human hair. The fibers help the cells hold their shape, “kind of like rebar in concrete,” Moore said.

But unlike rebar, she added, “they’re constantly moving and changing.” Normally, features like these are too small and quick to see with conventional microscopes, which can only take a few images a second or are too out-of-focus. So Kiehart’s team used a technique called super-resolution fluorescence microscopy to track individual fibers with nanoscale resolution.

By watching the “rebar of the cell” at work during this hole-closing process in fruit flies, the researchers hope to better understand wound healing in humans, and what goes awry for children with birth defects such as cleft lip and spina bifida.

LEARN MORE: “Super-resolution microscopy reveals actomyosin dynamics in medioapical arrays,” Regan P. Moore, Stephanie M. Fogerson, U. Serdar Tulu, Jason W. Yu, Amanda H. Cox, Melissa A. Sican, Dong Li, Wesley R. Legant, Aubrey V. Weigel, Janice M. Crawford, Eric Betzig, and Daniel P. Kiehart. Molecular Biology of the Cell, July 15, 2022. DOI: 10.1091/mbc.E21-11-0537

#UniqueScientists Is Challenging Stereotypes About Who Becomes a Scientist

University of North Carolina cell biologist Efra Rivera-Serrano says he doesn’t look like a stereotypical scientist: he’s gay, Puerto Rican, and a personal trainer.

Known on Twitter as @NakedCapsid or “the guy who looks totally buff & posts microscopy threads,” he tweets about virology and cell biology and aims to make science more accessible to the non-science public.

But science communication encompasses more than posting the facts of viral transmission or sending virtual valentines featuring virus-infected cells, Rivera-Serrano says. As a science communicator, he’s also committed to conveying truths that are even more rarely expressed in the science world today. He’s committed to diversity.

Rivera-Serrano’s path through academia has been far from linear — largely because of the microaggressions (which are sometimes not so micro) that he’s faced within educational institutions. He’s been approached while shopping by a construction work recruiter and told by a graduate adviser in biology to “stop talking like a Puerto Rican.”

Efra Rivera-Serrano, Ph.D.
He’s a scientist at UNC—and also a personal trainer.
Photo from @NakedCapsid Twitter

And the worst part is that he’s far from being the only one in this kind of position. That’s why Rivera-Serrano holds one simple question close to heart:

What would a cell do?

“I use this question to shape the way I tackle problems,” Rivera-Serrano says. After all, a key component of virology is the importance of intercellular communication in controlling disease spread. Similarly, a major goal of diversity-related science communication is “priming” others to fight stereotypes and biases about who belongs in science.

Virology’s “herd immunity” theory operates under the principle that higher vaccination rates mean fewer infections. For some viruses, a 90% vaccination rate is all it takes to completely eradicate an infection from existing in a population. Rivera-Serrano, therefore, hopes to use inclusive science communication as a vaccination tool of sorts to combat discriminatory practices and ideologies in science. He isn’t looking for 100% of the world to agree with him—only enough to make it work.

Herd immunity places value on community rather than individuals.
Image by Tkarcher via Wikimedia Commons

This desire for “inclusive science communication” led Rivera-Serrano to found Unique Scientists, a website that showcases and celebrates diverse scientists from across the globe. Scientists from underrepresented backgrounds can submit a biography and photo to the site and have them published for the world’s aspiring scientists to see.

Some Unique Scientists featured on Rivera-Serrano’s site!

Generating social herd immunity needs to start from an early age, and Unique Scientists has proven itself useful for this purpose. Before introducing the website, school teachers asked their students to draw a scientist. “It’s usually a man who’s white with crazy hair,” according to Rivera-Serrano. Then, they were given the same instructions after browsing through the site, and the results were remarkable.

“Having kids understand pronouns or see an African American in ecology—that’s all something you can do,” Rivera-Serrano explains. It doesn’t take an insane amount of effort to tackle this virus.

What it does take, though, is cooperation. “It’s not a one-person job, for sure,” Rivera-Serrano says. But maybe we can get there together.

by Irene Park

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